M E D I C U S - Shoqata e Mjekëve Shqiptarë të Maqedonisë-Hipokrati
M E D I C U S - Shoqata e Mjekëve Shqiptarë të Maqedonisë-Hipokrati M E D I C U S - Shoqata e Mjekëve Shqiptarë të Maqedonisë-Hipokrati
Применливоста на методата е во тоа што со репетирани мерења на Доплер васкуларните параметри и нивно експресионирање преку DPI и со внесување на биохуморалните вредности во индексот FLI, во секое време може да се направи staging (разлика во степенот) на замастување на црниот дроб, кое е попрецизно од испитувањата со класичната B-mode ехотомографија. Имајќи ја методата пред себе, може да се примени во текот на разни иследувања, при испитување на ефектот на нови или клинички докажани лекови кои влијаат на стеатозата, уште пред промените да бидат видливи со класичната ехотомографија или лабораториските иследувања. ЛИТЕРАТУРА 1. Alexandra vH,, Thomas F, Dieter H, Association between duplex Doppler sonographic flow pattern in right hepatic vein and various liver diseases. Journal of Clinical Ultrasound Volume 29 Issue 1, Pages 25 – 30 2. Aubin B, Denys A, Lafortune M, Dery R. Focal Sparting of Liver Parenchyma Steatosis. J Ultasound Medicine Feb; 14:77-80 1995 3. Kakkos S K, Yarmenitis S D, Tsmandas AC. Fatty liver in obesity: Relation to Doppler perfusion index measurement of the liver. Scandinavian journal of gastroenterology ISSN 0036-5521 4. Li-Ping Liu, Bao-Wei Dong, Xiao-Ling Yu et al. Analysis of Focal Spared Areas in Fatty Liver Using Color Doppler Imaging and Contrast-Enhanced Microvessel Display Sonography. J Ultrasound Med 27:387-394 • 0278-429 5. Miyagawa S, Makuuchi M. Liver intraoperative ultrasound of superficial structures. Edinburg 1995, pp 395-402 6. Schneider AR, Teuber G, Caspary WF. Noninvasive assessment of liver steatosis, fibrosis and inflammation in chronic hepatitis C virus infection. PMID: 16343065 PubMed 7. Tiribelli C, Bedogni G, Bellentani S. et al. The Fatty Liver Index: A Simple and Accurate Predictor of Hepatic Steatosis in the General Population, BMC Gastroenterology, ISSN: 1471-230X. 8. http://www.medscape.com/viewpublication/21020_about SUMMARY FATTY LIVER INDEX (FLI) AND DOPPLER PERFUSION INDEX (DPI) ALTERATION UNDER L-ORNITHINUM- L-ASPARTICUM (HEPA-MERZ ® ) AND SIMVASTATIN THERAPY Zaklina Servini 1 , Petar Avramovski 1 , Simeon Siljanovski 1 , Izabela Filov 2 , 1 Dominika Todorovska Rajchanovska 1 Clinical Hospital – Bitola 2 Neuropsychiatric Hospital – Demir Hisar
In our study were estimate together 40 patients (24 male et 16 female, from 31 to 65 year age, with mean age of 43, 7) with liver steatosis: that mean 30 patients examined in hospital (Clinical Hospital ―D-r Trifun Panovski‖, Bitola, Department of Internal medicine), and the rest of them were examined ambulatory (Gastroenterological ambulance in Clinical Hospital – Bitola). The aim of the study is to represent decrease of Doppler ultrasound parameters Doppler Perfusion Index (DPI) and laboratories analysis indexes - Fatty Liver Index (FLI) during treatment of liver steatosis by L-ornitin – L- asparticum (Hepa Merz ® ). We estimate 40 objects with fatty liver continuity treated by L-ornitin–L-asparticum (Hepa Merz ® ) during two months study. The control group content 40 object too, with fatty changes and increase of triglycerides and increase of amintransferases activity. This group was treated only by simvastatin (Tabl.Cholipam®) a 20 mg. This group who was treated with monotherapy during first month, had decreased of perfusion index from 0, 31(0, 26±0, 12) to 0, 27±0,2. Patients with BMI elevation have more increased DPI (p=0, 03). The patients treated with adjuvant therapy of L-ornitin-L-asparrticum during the same period results with decrease of DPI index to 0, 23±0, 2. The same results we get consecutive with FLI decreased value. After all, the degree of liver steatosis is successfully in quantification by DPI and FLI, as relevant markers for monitoring of homodynamic and biochemical parameters in liver steatosis and monitoring during different types of medical treatment and records the different effects of medical therapy. Key words: DPI, FLI, Color Doppler Duplex, Steatosis. ///////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////// ///////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////// MEDICUS PUNIM PROFESIONAL / PROFESIONAL PAPER RADIOLOGJI ПОРТАЛНИОТ ПУЛСАТИВЕН ИНДЕКС КАКО ИНДИКАТОР НА ДЕСНО СРЦЕВА СЛАБОСТ Симеон Силјановски 1 , Петар Аврамовски 1 1 ЈЗУ, Клиничка болница ―Д-р Т. Пановски― , Битола Симеон Силјановски, лекар неурорадиолог Ул. 12 Кладенци бр 14, Битола Тел: 070 235 350
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In our study were estimate together 40 patients (24 male et 16 female, from 31 to<br />
65 year age, with mean age of 43, 7) with liver steatosis: that mean 30 patients examined<br />
in hospital (Clinical Hospital ―D-r Trifun Panovski‖, Bitola, Department of Internal<br />
medicine), and the rest of them were examined ambulatory (Gastroenterological<br />
ambulance in Clinical Hospital – Bitola). The aim of the study is to represent decrease of<br />
Doppler ultrasound parameters Doppler Perfusion Index (DPI) and laboratories analysis<br />
indexes - Fatty Liver Index (FLI) during treatment of liver steatosis by L-ornitin – L-<br />
asparticum (Hepa Merz ® ). We estimate 40 objects with fatty liver continuity treated by<br />
L-ornitin–L-asparticum (Hepa Merz ® ) during two months study. The control group<br />
content 40 object too, with fatty changes and increase of triglycerides and increase of<br />
amintransferases activity. This group was treated only by simvastatin (Tabl.Cholipam®)<br />
a 20 mg. This group who was treated with monotherapy during first month, had<br />
decreased of perfusion index from 0, 31(0, 26±0, 12) to 0, 27±0,2. Patients with BMI<br />
elevation have more increased DPI (p=0, 03). The patients treated with adjuvant therapy<br />
of L-ornitin-L-asparrticum during the same period results with decrease of DPI index to<br />
0, 23±0, 2. The same results we get consecutive with FLI decreased value. After all, the<br />
degree of liver steatosis is successfully in quantification by DPI and FLI, as relevant<br />
markers for monitoring of homodynamic and biochemical parameters in liver steatosis<br />
and monitoring during different types of medical treatment and records the different<br />
effects of medical therapy.<br />
Key words: DPI, FLI, Color Doppler Duplex, Steatosis.<br />
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MEDICUS<br />
PUNIM PROFESIONAL / PROFESIONAL PAPER RADIOLOGJI<br />
ПОРТАЛНИОТ ПУЛСАТИВЕН ИНДЕКС КАКО ИНДИКАТОР НА ДЕСНО<br />
СРЦЕВА СЛАБОСТ<br />
Симеон Силјановски 1 , Петар Аврамовски 1<br />
1 ЈЗУ, Клиничка болница ―Д-р Т. Пановски― , Битола<br />
Симеон Силјановски, лекар неурорадиолог<br />
Ул. 12 Кладенци бр 14, Битола<br />
Тел: 070 235 350
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