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Acta Oncologica Turcica 2022; 55: 85-9292matched comparison, European Journal of SurgicalOncology. 2010: 36 (7); 691-698.34. Zhang G, Yu X, Zhu L, Fan Q, Lang J. Preoperativeclinical characteristics scoring system fordifferentiating uterine leiomyosarcoma from fibroid.BMC Cancer. 2020; 20(1): 514-52135. Namkung J, Kim YW, Kim JY et al.Lymphocyte-monocyte ratio predicts uterine sarcomaaggressiveness. Clinical and Experimental Obstetrics &Gynecology. 2019; 46(6): 953-957.36. Jeong MJ, Park JH, Hur SY, Kim CJ, Nam HS, LeeYS. Preoperative Neutrophil-to-Lymphocyte Ratio as aPrognostic Factor in Uterine Sarcoma. Journal ofClinical Medicine. 2020; 9(9):2898.Corresponding author e-mail: drsezert@gmail.comOrcid ID:Sezgin Ertürk Aksakal 0000-0002-6810-2199Hilal Korkmaz 0000-0003-1689-630XVakkas Korkmaz 0000-0002-6230-9519Doi: 10.5505/aot.2022.50570www.actaoncologicaturcica.comCopyright©Ankara Onkoloji Hastanesi
Acta Oncologica Turcica 2022; 55: 93-10293Original ArticleClinicopathological Features and Survival Outcomes of 70 Tongue SquamousCell Carcinoma PatientsYetmiş Dil Skuamöz Hücre Karsinomu Hastasının Klinikopatolojik Özelliklerive Sağ Kalım SonuçlarıSelin Aktürk Esen 1 , Denizcan Hastürk 2 , Seda Kahraman 3 , Yakup Ergun 4 , Gökhan Uçar 1 ,Yusuf Acikgoz 1 , Emre Hafızoğlu 1 , Öznur Bal 1 , Efnan Algın 1 , Fahriye Tugba Köş 1 ,Mehmet Sendur 3 , Doğan Uncu 11Ankara City Hospital, Department of Medical Oncology2Ankara City Hospital, Department of Internal Medicine3Ankara Yıldırım Beyazıt University Faculty of Medicine, Department of Medical Oncology4Batman Training and Research Hospital, Department of Medical OncologyABSTRACTIntroduction: In this article, it is aimed to present the clinicopathological and demographiccharacteristics, treatment regimens and survival characteristics of locally advanced tongue squamouscell cancers (TSCC).Materials and methods: This retrospective study included patients with histologically confirmedlocally advanced TSCC followed up at the medical oncology clinic between January 2005 and June2020. Clinicopathological features and treatment modalities of the patients were recorded from thehospital's patient registry database. The obtained data were compared statisticallyResults: A total of 70 patients, 42 male and 28 female, were included in the study. The 5-year OS wasfound to be 59%. The median disease free survival (DFS) was 4.1 years. OS could not reach the medianin the 2/3 anterior tumors of the tongue, while the median OS was 6.9 years in the 1/3 posterior tumorsof the tongue (p=0.046). There was no statistically significant difference between age groups in termsof median OS and median DFS. But there was a remarkable point. The median DFS was numericallyshorter in patients aged 45 years and younger than in patients over 45 years of age (2 years vs. 4.5 years).Also important here was that both the median OS and the median DFS were numerically worse in women(respectively, median OS: 4.1 years vs. not reached, p=0.075; median DFS: 2.2 years vs. 5.9 years,p=0.349).Discussion: There are few studies that examine TSCC as a separate title under these headings of oralcavity cancers and oropharyngeal cancers. In this sense, this study will contribute to the literature.Keywords: oral cavity cancers, oropharengeal cancers, tongue squamous cell cancersÖZETGiriş: Bu yazıda, lokal ileri dil skuamöz hücreli kanserlerin (DSCC) klinikopatolojik ve demografiközellikleri, tedavi rejimleri ve sağkalım özelliklerinin sunulması amaçlanmaktadır.Gereç ve yöntemler: Bu retrospektif çalışma, Ocak 2005 ile Haziran 2020 arasında medikal onkolojikliniğinde takip edilen, patolojik olarak doğrulanmış lokal ileri DSCC'li hastaları içermektedir.Hastaların klinikopatolojik özellikleri ve tedavi yöntemleri hastanenin hasta kayıt veritabanındankaydedilmiştir. Elde edilen veriler istatistiksel olarak karşılaştırılmıştır.Bulgular: Çalışmaya 42 erkek ve 28 kadın olmak üzere toplam 70 hasta dahil edildi. 5 yıllık gene sağkalım (OS) %59 olarak bulundu. Medyan hastalıksız sağ kalım (DFS) 4.1 yıldı. Dil ön 2/3 tümörlerindeOS medyana ulaşamadı, dilin 1/3 arka tümörlerinde medyan OS 6.9 yıldı (p=0.046). Medyan OS vemedyan DFS açısından yaş grupları arasında istatistiksel anlamlı fark yoktu. Ancak dikkat çekici nokta,medyan DFS 45 yaş ve altındaki hastalarda, 45 yaşın üzerindeki hastalardan (2 yıla karşı 4,5 yıl) sayısalolarak daha kısaydı. Ayrıca hem medyan OS hem de medyan DFS kadınlarda numerik olarak dahaFirst Received: 08.12.2021, Accepted: 25.02.2022doi: 10.5505/aot.2022.59002
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