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Acta Oncologica Turcica 2022; 55: 165-17317313. Veen T, Søreide K. Can molecular biomarkersreplace a clinical risk score for resectable colorectalliver metastasis? World Journal of GastrointestinalOncology. 2017; 9(3): 98.14. Manfredi S, Lepage C, Hatem C, Coatmeur O,Faivre J, Bouvier A-M. Epidemiology and Managementof Liver Metastases from Colorectal Cancer. Annals ofSurgery. 2006; 244(2): 254-259.15. Leporrier J, Maurel J, Chiche L, Bara S, Segol P,Launoy G. A population-based study of the incidence,management and prognosis of hepatic metastasesfrom colorectal cancer. British Journal of Surgery. 2006;93(4): 465-474.16. Lupinacci RM, Andraus W, De Paiva HaddadLB, Carneiro D′Albuquerque LA, Herman P.Simultaneous laparoscopic resection of primarycolorectal cancer and associated liver metastases: asystematic review. Techniques in Coloproctology.2013; 18(2):129-135.17. Pendlimari R, Holubar SD, Pattan-Arun J, et al.Hand-assisted laparoscopic colon and rectal cancersurgery: Feasibility, short-term, and oncologicaloutcomes. Surgery. 2010; 148(2): 378-385.18. Yang I, Boushey RP, Marcello PW. Handassistedlaparoscopic colorectal surgery. Techniques inColoproctology. 2013; 17(S1): 23-27.19. Kang JC, Chung MH, Chao PC, et al. Handassistedlaparoscopic colectomy vs open colectomy: aprospective randomized study. Surgical Endoscopy.2004; 18(4): 577-581.20. Tong G, Zhang G, Liu J, Zheng Z, Chen Y, Cui E.A meta-analysis of short-term outcome of laparoscopicsurgery versus conventional open surgery on colorectalcarcinoma. Medicine. 2017; 96(48): e8957.21. Zhang X, Wu Q, Gu C, Hu T, Bi L, Wang Z. Handassistedlaparoscopic surgery versus conventional opensurgery in intraoperative and postoperative outcomesfor colorectal cancer. Medicine. 2017; 96(33): e7794.Corresponding author e-mail: cemzcan@gmail.comOrcid ID:Veysel Cem Özcan 0000-0001-6445-1343Suat Kutun 0000-0003-1219-1855Kubilay Kenan Özlük 0000-0002-8496-539XEda Güner 0000-0001-6633-7691Bülent Aksel 0000-0002-2498-664XLütfi Doğan 0000-0002-3834-0911Cihangir Özaslan 0000-0002-2611-4837Doi: 10.5505/aot.2022.67699www.actaoncologicaturcica.comCopyright©Ankara Onkoloji Hastanesi
Acta Oncologica Turcica 2022; 55: 174-179174Original ArticleEvaluation of Factors Associated with Retinal Hemorrhage in Patients withAcute LeukemiaAkut Lösemili Hastalarda Retina Kanaması ile İlişkili FaktörlerinDeğerlendirilmesiSibel Özdoğan 1 , Ayşenur Çelik 1 , Semih Başcı 21Department of Ophthalmology, Dr. Abdurrahman Yurtaslan Oncology Training and ResearchHospital, University of Health Sciences, Urankent, Yenimahalle, Ankara, Turkey2Department of Hematology and Bone Marrow Transplantation Center, Dr. Abdurrahman YurtaslanOncology Training and Research Hospital, University of Health Sciences, Urankent, Yenimahalle,Ankara, TurkeyABSTRACTPurpose: We aimed to investigate the association of retinal hemorrhage and blood parameters in patientswith acute leukemiaMaterial-Methods: We have retrospectively investigated sixty-one acute leukemia patients with andwithout retinal hemorrhages and analyzed associated factors. Patients underwent a detailed ocularexamination. The hematological and coagulation parameters were based on data when the retinalhemorrhages were noticed in the fundus.Results: The study group consisted of 30 patients with acute myelocytic leukemia (AML) and acutelymphocytic leukemia (ALL) who had retinal hemorrhages and the control group consisted of 31patients with acute leukemia without retinal hemorrhages. Approximately ½ of the patients had lowvision due to retinal hemorrhage, while the other half were detected by meticulous eye examination.AML diagnosis was statistically more frequent in patients with retinal hemorrhage (p=0.02). Activedisease was statistically more common in the patients with retinal hemorrhage (p=0.03). In the retinalhemorrhage group, patients had significantly lower hemoglobin, hematocrit, and platelet levels thanthose without hemorrhages (p=0.001, p=0.001 and p=0.001 respectively). There was no statisticallysignificant difference in leukocytes values between two groups (p=0.634).Conclusion: In present study we found correlation between the hematological parameters and retinalhemorrhages. In patients with active AML and profound thrombocytopenia, a visual examination shouldbe prioritized since ocular problems may go unnoticed since many patients are asymptomatic.Key Words: Leukemia, retina, retinal hemorrhage, leucocyte, thrombocytopeniaÖZETAmaç: Akut lösemili hastalarda retina kanaması ile kan parametreleri arasındaki ilişkiyi araştırmayıamaçladıkGereç ve Yöntem: Retina kanaması olan ve olmayan 61 akut lösemi hastasını geriye dönük olarakaraştırdık ve ilişkili faktörleri analiz ettik. Hastalara detaylı göz muayenesi yapıldı. Hematolojik vepıhtılaşma parametreleri, fundusta retina kanamalarının fark edildiği andaki verilere dayanıyordu.Bulgular: Çalışma grubunu retina kanaması olan akut miyelositik lösemili (AML) ve akut lenfositiklösemili (ALL) 30 hasta, kontrol grubunu ise retina kanaması olmayan 31 akut lösemi hastası oluşturdu.Hastaların yaklaşık ½'sinde retina kanamasına bağlı az görme mevcutken, diğer yarısı titiz bir gözmuayenesi ile tespit edildi. AML tanısı retina kanaması olan hastalarda istatistiksel olarak daha sıktı(p=0,02). Retina kanaması olan hastalarda aktif hastalık istatistiksel olarak daha yaygındı (p=0.03).Retinal kanama grubunda, hastaların hemoglobin, hematokrit ve trombosit düzeyleri kanamasıolmayanlara göre anlamlı derecede daha düşüktü (sırasıyla p=0,001, p=0,001 ve p=0,001). İki gruparasında lökosit değerlerinde istatistiksel olarak anlamlı fark yoktu (p=0,634).First Received: 08.04.2022, Accepted: 21.04.2022doi: 10.5505/aot.2022.97992
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