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166. Pinyol M, Hernandez L, Martinez A, et al. INK4a/ARF locus alterations in human non-Hodgkin’slymphomas mainly occur in tumors with wild-type p53 gene. Am J Pathol 2000;156:1987-96.167. Koduru PR, Raju K, Vadmal V, et al. Correlation between mutation in P53, p53 expression,cytogenetics, histologic type, and survival in patients with B-cell non-Hodgkin’s lymphoma. Blood1997,90:4078-91.168. Sanchez-Beato M, Saez AI, Navas IC, et al. Overall survival in aggressive B-cell lymphomas isdependent on the accumulation of alterations in p53, p16 and p27. Am J Pathol 2001;159:205-13.169. Moller MB, Ino Y, Gerdes AM, Skjodt K, Louis DN, Pedersen NT. Aberrations of the p53 pathwaycomponents p53, MDM2 and CDKN2A appear independent in diffuse large B cell lymphoma.Leukemia 1999;13.453-9.170. Villuendas R, Piris MA, Algara P, et al. The expression of p53 protein in non-Hodgkin’s lymphomas isnot always dependent on p53 gene mutations. Blood 1993;82:3151-6.171. Villuendas R, Pezzella F, Gatter K, et al. p21WAF1/CIP1 and MDM2 expression in non-Hodgkin’slymphoma and their relationship to p53 status: a p53+, MDM2-, p21- immunophenotype associatedwith missense p53 mutations. J Pathol 1997;181:51-61.172. Wilson W, Teruya-Feldstein J, Fest T. Relationship of p53, bcl2 and tumor proliferation to clinicaldrug resisitance in non-Hodgkin’s lymphomas. Blood 1997;89:601-9.173. Ichikawa A, Kinoshia T, Watanabe T, et al. Mutations of the p53 gene as a prognostic factor inaggressive B-cell lymphoma. New Engl J Med 1997;337:529-34.174. Leroy K, Haioun C, Lepage E, et al. p53 gene mutations are associated with poor survival in low andlow-intermediate risk diffuse large B-cell lymphoma. Ann Onclo 2002,13.1108-15.175. Kerbauy FR, Colleoni GW, Saad ST, et al. Detection and possible prognostic relevance of p53 genemutations in diffuse large B-cell lymphoma. An analysis of 51 cases and review of the literature. LeukLymphoma 2004;45:2071-8.176. Llanos M, Alvarez-Arguelles H, Aleman R, Oramas J, Diaz-Flores L, Batista N. Prognosticsignificance of Ki-67 nuclear proliferative antigen, bcl-2 protein and p53 expression in follicular anddiffuse large b-cell lymphoma. Med Oncol 2001;18:15-22.

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