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44. Viardot A, Moller P, Hogel J, et al. Clinicopathologic correlations of genomic gains and losses infollicular lymphoma. J Clin Oncol 2002;20:4523-30.45. Horsman DE, Connors JM, Pantzar T, Gascoyne RD. Analysis of secondary chromosomal alterationsin 165 cases of follicular lymphoma with t(14,18). Genes Chromosomes Cancer 2001;30:375-82.46. Hoglund M, Shen L, Connors JM, et al. Identification of cytogenetic subgroups and karyotypicpathways of clonal evolution in follicular lymphomas. Genes Chromosomes Cancer 2004;39:195-204.47. Küppers R. Prognosis in follicular lymphoma – it’s in the microenvironment. New J Med2004;351:2152-3.48. Dave SS, Wright G, Tan B, et al. Prediction of survival in follicular lymphoma based on molecularfeatures of tumor-infiltrating immune cells. N Engl J Med 2004;351:2159-69.49. Horning SJ, Rosenberg SA. The natural history of initially untreated low-grade non-Hodgkin’slymphoma. N Engl J Med 1984:311:1471-5.50. Rohatiner AZS, Lister TA. The clinical course of follicular lymphoma. Best Pract Res Clin Haematol2005;18:1-10.51. Plancarte F, Lopez-Guillermo A, Arenillas L, et al. Follicular lymphoma in early stages: high risk ofrelapse and usefulness of the Follicular Lymphoma International Prognostic Index to predict theoutcome of patients. Eur J Haematol 2006;76:58-63.52. Guo Y, Karube K, Kawano R, et al. Low-grade follicular lymphoma with t(14;18) presents ahomogeneous disease entity otherwise the rest comprises minor groups of heterogeneous diseaseentities with Bcl2 amplification, Bcl6 translocation or other gene aberrances. Leukemia 2005;19:1058-63.53. Schraders M, de Jong D, Kluin P, Groenen P, van Krieken H. Lack of bcl-2 expression in follicularlymphoma may be caused by mutations in the bcl2 gene or by absence of the t(14;18) translocation. JPathol 2005,205:329-35.54. Horsman DE, Okamoto I, Ludkovski O, et al. Follicular lymphoma lacking the t(14;18)(q32;q21):identification of two disease subtypes. Br J Haematol 2003;120:424-33.

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