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ABC imunofenotipom. Imunofenotipski karakterizirane skupine GCB i ABC suprognostički značajan pokazatelj.
8. Summary73 patients with lymph nodes enlargement were classified, according WHO lymphomaclassification into DLBCL (53 cases) and FL-3 predominantly follicular arhitecture,>75% (20 cases). Expression of markers was detected by immunohistochemical methodand cytogenetic abnormalities were analysed by FISH.The results have shown no differences in survival of DLBCL and FL-3 predominantlyfollicular arhitecture, >75%, which are two different morphological entities accordingWHO classification, but differences in patients age and IPI were detected. In cases ofDLBCL and FL-3 were not found differences in BCL2, BCL6 genes abnormalities andBCL2 protein expression. The BCL6 protein expression was more frequently found inFL-3. Morphological entities DLBCL and FL-3 were equal represent in GCB and ABCgroups, which were defined according CD10, BCL6, MUM1/IRF4 and CD138expression. The t(14;18)(q32;q21) was more frequently found in the GCB group, andt(14;18)(q32;q21) with additional BCL2 signals or only additional BCL2 and IgH signalsin the ABC group. t(14;18)(q32;q21) represent an initial mechanism in the pathogenesisof GCB group. Amplification of BCL2 gene is frequently present in ABC group. In theGCB and ABC groups were not detected differences in BCL6 gene abnormanlities.Multivariate regression analysis was shown no prognostic significance of the expressionof each BCL6 and CD10 protein expression, the BCL2 and BCL6 genes abnormalitiesand the IPI. Also in GCB and ABC groups were not detected differences in the IPI.GCB and ABC immunophenotype groups were defined as independent prognosticpredictors.
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Središnja medicinska knjižnicaBor
Page 3 and 4:
Disertacija je izrađena u Odjelu z
Page 5 and 6:
3.4 Interfazna fluorescentna in sit
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H&E - hemalaun & eozinHIV - virus h
Page 9 and 10:
klasifikacije limfoidnih neoplazmi
Page 11 and 12:
Folikularni limfom (FL) - 25% svih
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simptoma. MPI obuhvaća dob bolesni
Page 15 and 16:
1.4 DNA microarray analiza genske e
Page 17 and 18: molekularno različitih bolesti unu
Page 19 and 20: Monoklonalna protutijela za pojedin
Page 21 and 22: Common acute lymphoblastic leukaemi
Page 23 and 24: Interakcijom s različitim efektors
Page 25 and 26: između fenotipskih skupina i vrije
Page 27 and 28: BCL2 protein je eksprimiran u stani
Page 29 and 30: p53 protein se imunohistokemijski n
Page 31 and 32: 2. Ciljevi istraživanja1. U primar
Page 33 and 34: uključuje - MPI score 3 - veliki i
Page 35 and 36: 3.2 Tkivni microarrayUzorci s dovol
Page 37 and 38: fenotipom, a fenotipski uzorci CD10
Page 39 and 40: Slika 1. Shematski prikaz LSI IgH p
Page 41 and 42: 3.4.3 Analiza preparataKorišten je
Page 43 and 44: 4. Rezultati4.1.1 Fenotipske karakt
Page 45 and 46: Odnos imunofenotipskih skupina GCB
Page 47 and 48: U slučajevima bez t(14;18)(q32;q21
Page 49 and 50: 4.2 Usporedba proteinske ekspresije
Page 51 and 52: Usporedbom imunofenotipskih skupina
Page 53 and 54: 4.3 Usporedba utjecaja fenotipskih
Page 55 and 56: Međutim, imunofenotipske skupine G
Page 57 and 58: Uočena je statistički značajna r
Page 59 and 60: učestalost t(14;18)(q32;q21) u GCB
Page 61 and 62: iljega, MUM1/IRF4 i BCL6. Isto tako
Page 63 and 64: kriterija, prema današnjim spoznaj
Page 65 and 66: ekspresije gena koja bi imala za po
Page 67: 7. Sažetak73 bolesnika s povećani
Page 71 and 72: 11. Morgensztern D, Lossos IS. Mole
Page 73 and 74: 33. Nanjangud G, Rao PH, Hegde A, e
Page 75 and 76: 55. Bosga-Bouwer AG, van Imhoff GW,
Page 77 and 78: 78. Lossos IS, Alizadeh AA, Diehn M
Page 79 and 80: 100. Pescarmona E, De Sanctis V, Pi
Page 81 and 82: 122. Fabiani B, Delmer A, Lepage E,
Page 83 and 84: 143. Poulsen CB, Borup R, Nielsen F
Page 85 and 86: 166. Pinyol M, Hernandez L, Martine
Page 87 and 88: 189. Rubin MA, Dunn R, Strawderman
Page 89: Aktivno sam sudjelovala na 3 međun
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