Primary rat and mouse hepatic stellate cells express the macrophage inhibitor cytokineinterleukin-10 during the course of activation In vitro. Hepatology 1998;28(6):1518-24.242. Olaso E, Eng F, Lin C, Yancopoulos G, Friedman SL. Hepatology 1999;30:413.243. Iredale JP, Benyon RC, Pickering J, McCullen M, Northrop M, Pawley S et al.Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cellapoptosis and reduced hepatic expression of metalloproteinase inhibitors. J Clin Invest1998;102(3):538-49.244. Gressner AM. The cell biology of liver fibrogenesis - an imbalance of proliferation,growth arrest and apoptosis of myofibroblasts. Cell Tissue Res 1998;292(3):447-52.245. Gerbes AL, Moller S, Gulberg V, Henriksen J.Endothelin-1 and -3 Plasmaconcentracion in patients with cirrhosis. Role of splanchnic and renal passage and liverfunction. Hepatology 1995;21:735-9.246. Moore K, Wendon J, frazer M, Karani J, Williams R, Badr K. Plasma endothelinimmunoreactivity in liver disease and the hepatorenal syndrome. N Engl J Med1992;327:1774- 8.247. Cho J-J, Hocher B, Herbst H, Jia J-D, Ruehi M, Hahn EG,et al. An oral endothelin A-receptor antagonist block collagen syntesis and deposition in advanced rat liverfibrosis. Gasroenterology 2000;118:1169-78.248. Ishak K, et al. Histological grading and staging of chronic hepatitis. J Hepatology1995;22:696-99.249. Holmquist L., Mattern, F., Schiele, B., Alahuhta, P., Beigl, M., and Gellersen, H.Smart-its friends: A technique for users to easily establish connections between smartartefacts. In Proc. of UBICOMP 2001, Atlanta, GA, US,250. Ando K, Hirata Y, Schichiri M, Emori T, Marumo F. Presence immunoreactiveendothelin in human plasma.FEBS Let 1989;245:164-166.251. Hourani JM, Bellamy PE, Taskin DP, Simmons MS. Pulmonary dysfunction inadvanced liver cirrhosis: frequent occurence of an abnormal disffusing capacity. Am JMed 1991;90:693-700.252. Karetzky MS, Mithofer JC. The cause of hiperventilation an arterila hypoxia inpatients with cirrhosis of the liver. Am J Med Sci 1967;254:797-804.253. Davis HH, Schwartz DJ, Lefrak SS, SusmanN, Schainker BA. Alveola-capyllaryoxygen disequilibrium in hepatic cirrhosis. Chest 1978;73:507-11.125
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SVEUČILIŠTE U ZAGREBUMEDICINSKI F
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POPIS KRATICAACEangiotenzin konvert
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3. ISPITANICI i METODE.............
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1.1. RENIN ANGIOTENZIN SUSTAV (RAS)
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Slika 2. "Novi" koncept klasičnog
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1.1.1. AngiotenzinogenSupstrat reni
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i renina nađene su i u neferktomir
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Snižena plazmatska aktivnost renin
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Slika 3. Shematski prikaz krvožiln
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Izvanplućna konverzija angiotenzin
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Radovi Osborna i Studera (65,66) i
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Naša su istraživanja pokazala da
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1.1.7. Angiotenzin (1-7)Angiotenzin
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(114,115). Sve je više dokaza za p
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Slika 6. Mehanizam djelovanja endot
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Strukturno vrlo sličan ljudskim en
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afinitetom receptora (135). Cistein
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Uloga endotelina u patofiziologiji
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1.2.3.1. Učinci na kardiovaskularn
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1.2.4.2. Učinci ET-1 na regulaciju
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učinkom prostaglandin E2 relaksira
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subendotelijalnom prostoru. Naime,
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U in vivo uvjetima, neaktivne KC zd
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Molekularnim pristupom u istraživa
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s maksimumom nakon 48 sati (nakon g
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ožiljka. U oba tipa odgovora prisu
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dva inhibitora metaloproteinaza se
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Kao što je već prethodno istaknut
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Sintezu ET-1 među ostalim podstič
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3.1. IspitaniciU istraživanje je u
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3.2.2.Ultrazvučna pretraga i dople
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Slika 10. Indeks otpora (RI) protok
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4. REZULTATI67
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Tablica 7. Značajniji laboratorijs
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Serumske aktivnosti ACE, serumske k
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Indeks otpora (RI) u jetrenoj arter
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