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esponse of α2(I) collagen to transforming growth factor-β1. J Biol Chem1997;272:19738-45.220. Prakash S, Wyler DJ. Fibroblast stimulation in schistosomiasis XI. Purification toapparent homogeneity of fibroblast-stimulating factor-1, an acidic heparin-bindinggrowth factor produced by schistosomal egg granulomas. J Immunol 1991;146:1679-84.221. Prakash S, Nanji AA, Robbins PW. Fibrosin: a novel lymphokine in alcohol-inducedfibrosis. Exp Mol Pathol 1999;67:40-9.222. Greenwel P, Wyler DJ, Rojkind M, Prakash S. Fibroblast-stimulating factor-1, a novellymphokine produced in schistosomal egg granulomas, stimulates liver fat-storingcells in vitro. Inter Immun 1993;61:3985-7.223. Bradham DM, Igarashi S, Potter RL, Grotendorst GR. Connective tissue growthfactor: a cysteine-rich mitogen secreted by human vascular endothelial cells is relatedto the SRC-induced immediate early gene product CEF-10. J Cell Biol 1991;114:1285-94.224. Frazier K, Williams S, Kothapalli D, Klapper H, Grotendorst GR. Stimulation offibroblast cell growth, matrix production, and granulation tissue formation byconnective tissue growth factor. J Invest Dermatol 1996;107:404-11.225. Mori T, Kawara S, Shinozaki M, Hayashi N, Kakinuma T, Igarashi A, et al. Role andinteraction of connective tissue growth factor with transforming growth factor-β inpersistent fibrosis: A mouse fibrosis model. J Cell Physiol 1999;181:153-9.226. Sato S, Nagaoka T, Hasegawa M, Tamatani T, Nakanishi T, Takigawa M, et al. Serumlevels of connective tissue growth factor are elevated in patients with systemicsclerosis: association with extent of skin sclerosis and severity of pulmonary fibrosis. JRheumatol 2000;27:149-54.227. Williams EJ, Gaca MD, Brigstock DR, Arthur MJ, Benyon RC. Increased expressionof connective tissue growth factor in fibrotic human liver and in activated hepaticstellate cells. J Hepatol 2000;32:754-61.228. Kothapalli D, Hayashi N, Grotendorst GR. Inhibition of TGF-β-stimulated CTGF geneexpression and anchorage-independent growth by cAMP identifies a CTGF-dependentrestriction point in the cell cycle. FASEB J 1998;12:1151-61.229. Rojkind M, Mourelle M. The liver as a bioecological system: Modifications duringregeneration and repair: In: Nimni M, editor. Collagen: chemistry, biology and123

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