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170. Gandhi CR, Stephenson K, Olson MS. Endothelin, a potent peptide agonist in theliver. J Biol Chem 1990;265:17432-5.171. Zhang JX, Pegoli WJ, Clemens MG. Endothelin-1 induces direct constriction ofhepatic sinusoids. Am J Physiol 1994;266:G624-32.172. Tran-Thi TA, Kawada N, Decker K. Regulation of endothelin-1 action on the perfusedrat liver. FEBS Lett 1993;318:353-7.173. Oshita M, Takei Y, Kawano S, Yoshihara H, Hijioka T, Fukui H, et al. Roles ofendothelin-1 and nitric oxide in the mechanism for ethanol-induced vasoconstriction inrat liver. J Clin Invest 1993;91:1337-42.174. Bauer M, Zhang JX, Bauer I, Clemens MG. ET-1 induced alterations of hepaticmicrocirculation: sinusoidal and extrasinusoidal sites of action. Am J Physiol1994;267:G143-9.175. Zhang JX, Bauer M, Clemens MG. Vessel- and target cell-specific actions ofendothelin-1 and endothelin-3 in rat liver. Am J Physiol 1995;269:G269-77.176. Goto M, Takei Y, Kawano S, Nagano K, Tsuji S, Masuda E, et al. Endothelin-1 isinvolved in the pathogenesis of ischemia/reperfusion liver injury by hepaticmicrocirculatory disturbances. Hepatology 1994;19:675-81.177. Kawamura E, Yamanaka N, Okamoto E, Tomoda F, Furukawa K. Response of plasmaand tissue endothelin-1 to liver ischemia and its implication in ischemia-reperfusioninjury. Hepatology 1995;21:1138-43.178. Gandhi CR, Stephenson K, Olson MS. A comparative study of endothelin- andplatelet-activating-factor-mediated signal transduction and prostaglandin synthesis inrat Kupffer cells. Biochem J 1992;281:485-92.179. Mustafa SB, Gandhi CR, Harvey SAK, Olson MS. Endothelin stimulates plateletactivatingfactor synthesis by cultured rat Kupffer cells. Hepatology 1995;21:545-53.180. Kawada N, Klein H, Decker K. Eicosanoid-mediated contractility of hepatic stellatecells. Biochem J 1992;285-367-71.181. Rockey DC, Chung JJ. Inducible nitric oxide synthase in rat hepatic lipocytes and theeffect of nitric oxide on lipocyte contractility. J Clin Invest 1994;95:1199-206.182. Shah V, Toruner M, Haddad F, Cadelina G, Papapetropoulos A, Choo K, et al.Impaired endothelial nitric oxide syntese activity associated with enhanced caveolinbinding in experimental cirrhosis in the rat. Gastroenterology 1999;117:1222-28.183. Tanaka A, Katagiri K, Hoshino M, Hayakawa T, Tsukada K, Takeuchi T. Endothelin-119
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SVEUČILIŠTE U ZAGREBUMEDICINSKI F
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POPIS KRATICAACEangiotenzin konvert
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3. ISPITANICI i METODE.............
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1.1. RENIN ANGIOTENZIN SUSTAV (RAS)
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Slika 2. "Novi" koncept klasičnog
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1.1.1. AngiotenzinogenSupstrat reni
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i renina nađene su i u neferktomir
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Snižena plazmatska aktivnost renin
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Slika 3. Shematski prikaz krvožiln
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Izvanplućna konverzija angiotenzin
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Radovi Osborna i Studera (65,66) i
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Naša su istraživanja pokazala da
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1.1.7. Angiotenzin (1-7)Angiotenzin
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(114,115). Sve je više dokaza za p
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Slika 6. Mehanizam djelovanja endot
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Strukturno vrlo sličan ljudskim en
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afinitetom receptora (135). Cistein
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Uloga endotelina u patofiziologiji
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1.2.3.1. Učinci na kardiovaskularn
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1.2.4.2. Učinci ET-1 na regulaciju
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učinkom prostaglandin E2 relaksira
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subendotelijalnom prostoru. Naime,
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U in vivo uvjetima, neaktivne KC zd
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Molekularnim pristupom u istraživa
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s maksimumom nakon 48 sati (nakon g
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ožiljka. U oba tipa odgovora prisu
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dva inhibitora metaloproteinaza se
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Kao što je već prethodno istaknut
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Sintezu ET-1 među ostalim podstič
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3.1. IspitaniciU istraživanje je u
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3.2.2.Ultrazvučna pretraga i dople
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Slika 10. Indeks otpora (RI) protok
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4. REZULTATI67
Page 68 and 69: Tablica 7. Značajniji laboratorijs
Page 70 and 71: Serumske aktivnosti ACE, serumske k
Page 72 and 73: Indeks otpora (RI) u jetrenoj arter
Page 74 and 75: Granične vrijednosti serumske akti
Page 76 and 77: Slika 16. Prikaz granične vrijedno
Page 78 and 79: Slika 18. Prikaz granične vrijedno
Page 80 and 81: Slika 20. Prikaz serumske koncentra
Page 82 and 83: Slika 22. Prikaz serumske aktivnost
Page 84 and 85: 5. RASPRAVA85
Page 86 and 87: dinamičke sastavnice koja je modif
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Page 90 and 91: ET-1 preko ET A receptora smješten
Page 92 and 93: važan je modulator vaskularnog tla
Page 94 and 95: Nije jasan razlog ovakvim disonantn
Page 96 and 97: 1. Serumska aktivnost ACE i serumsk
Page 98 and 99: Dosadašnja istraživanja su pokaza
Page 100 and 101: korištenja ovih doplerskih paramet
Page 102 and 103: Former research showed elevated val
Page 104 and 105: 9. L I T E R A T U R A105
Page 106 and 107: 13. Dell'Italia LJ, Meng QC, Balcel
Page 108 and 109: of the angiotensin I-converting enz
Page 110 and 111: diabetes type, state of metabolic c
Page 112 and 113: medulla. Am J Physiol 2002;283:H181
Page 114 and 115: 119. Kohno M, Ikeda M, Jonchi M, Ho
Page 116 and 117: expressing the human ETA or ETB rec
Page 120 and 121: 1998;18:629-38.198. Sato E, Simpson
Page 122 and 123: esponse of α2(I) collagen to trans
Page 124 and 125: Primary rat and mouse hepatic stell
Page 126 and 127: Plasma endothelin levels in cirrhot
Page 128 and 129: 10. Ž I V O T O P I S129
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