expressing the human ETA or ETB receptor subtype. Biochem Biophys Res Commun1994;199:992-7.144. Herman WH, Simonson MS. Nuclear signaling by endothelin-1. J Biol Chem1995,270:11654-61.145. Lotersztajn S. Les endothelines. Medecine/Sciences 1993;9:1084-93.146. Stephenson K, Gandhi CR, Olson M. Biological actions of endothen. In: Vitamins andHormones, vol 48. New York: Academic Press., 1994:157-98.147. Fukuda N, Soma M, Izumi Y, Minato M, Watanabe Y, Watanabe M, Hatano M. Lowdoses of endothelin-3 elicit endothelium dependent vasodilatation which accompanieswith elevation of cyclic GMP. Jpn Circ J 1991;55:617-22.148. Remuzzi G, Benigni A. Endothelins in the control of cardiovascular and renalfunction. Lancet 1993;342:589-93.149. Clozel M, Breu V, Gray GA, Kalina B, Loeffler B-M, Burri K, et al. Pharmacologicalcharacterization of bosentan, a new potent orally active nonpeptide endothelin receptorantagonist. J Pharmacol Exp Therap 1994;270:228-35.150. Hay DWP, Henry PJ, Goldie RG. Endothelin and the respiratory system. TiPS1993;14:29-32.151. Masaki T, Yanigasawa M, Goto K. Physiology and pharmaclogy of endothelins. MedRes Rev 1992;12:391-421.152. Badr KF, Murraz JJ, Brezer MD, Takahashi K, Inagami T, Harris RC. Mesangial cell,glomerular and renal vascular responses to endothelin in the rat kidney. J Clin Invest1989;83:336-42.153. Simonson MS, Wann S, Mene P, Dubyak GR, Kester M, Nakazato Y, et al. Endothelinstimulates phospholipase C, Na+/H+ exchange, c-fos expression, and mitogenesis inrat mesangial cells. J Clin Invest 1989;83:708-12.154. Wagner-Mann C, Sturek M. Endothelin mediates Ca influx and release in porcinecoronary smooth muscle cells. Am J Physiol 1991;260(4PA 1):C771-7.155. Zoja C, Orisio S, Perico N, Benigni A. Morigi M, Benatti L, et al. Constitutiveexpression of endothelin gene in cultured human mesangial cell and its modulation bytransforming growth factor-beta thrombin, and thrombexane A2 analogue. Lab Invest1991;64:16-20.156. Emori T, Hirata Y, Marumo F. Specific receptors for endothelin-3 in cultured bovineendothelial cells and its mechanism of action. FEBS Lett 1990;263:261-4.117
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SVEUČILIŠTE U ZAGREBUMEDICINSKI F
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POPIS KRATICAACEangiotenzin konvert
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3. ISPITANICI i METODE.............
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1.1. RENIN ANGIOTENZIN SUSTAV (RAS)
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Slika 2. "Novi" koncept klasičnog
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1.1.1. AngiotenzinogenSupstrat reni
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i renina nađene su i u neferktomir
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Snižena plazmatska aktivnost renin
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Slika 3. Shematski prikaz krvožiln
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Izvanplućna konverzija angiotenzin
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Radovi Osborna i Studera (65,66) i
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Naša su istraživanja pokazala da
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1.1.7. Angiotenzin (1-7)Angiotenzin
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(114,115). Sve je više dokaza za p
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Slika 6. Mehanizam djelovanja endot
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Strukturno vrlo sličan ljudskim en
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afinitetom receptora (135). Cistein
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Uloga endotelina u patofiziologiji
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1.2.3.1. Učinci na kardiovaskularn
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1.2.4.2. Učinci ET-1 na regulaciju
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učinkom prostaglandin E2 relaksira
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subendotelijalnom prostoru. Naime,
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U in vivo uvjetima, neaktivne KC zd
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Molekularnim pristupom u istraživa
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s maksimumom nakon 48 sati (nakon g
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ožiljka. U oba tipa odgovora prisu
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dva inhibitora metaloproteinaza se
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Kao što je već prethodno istaknut
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Sintezu ET-1 među ostalim podstič
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3.1. IspitaniciU istraživanje je u
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3.2.2.Ultrazvučna pretraga i dople
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Slika 10. Indeks otpora (RI) protok
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