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Biochem 1994;220:37-43.132. Becker A, Haendler B, Hechler U, Schleuning W-D. Mutational analysis of humanendothelin receptors ET A and ET B . Eur J Biochem 1994;221:951-8.133. Krystek, Jr SR, Patel PS, Rose PM, Fisher SM, Kienzle BK, Lach DA, et al. Mutationof peptide binding site in transmembrane region of a G protein-coupled receptoraccounts for endothelin receptor subtype selectivity. J Biol Chem 1994;269:12383-6.134. Arai H, Hori S, Aramori I, Ohkubo H, Nakanishi S. Cloning and expression of acDNA encoding an endothelin receptor. Nature (London) 1990;348:730-2.135. Sakurai T, Yanagisava M, Takuva Y, Miyazaki H, Kimura S, Goto K, Masaki T.Cloning of cDNA encoding a non-isopeptide-selective subtype of the endothelinreceptor. Nature (London) 1990;348:732-5.136. Simonson MS, Dunn MJ. Cellular signaling by peptides of the endothelin gene family.FASEB J 1990;4:2989-3000.137. Jouneaux C, Mallat A, Serradeil-Le Gal C, Goldsmith P, Hanoune J, Lotersztajn S.Coupling of endothelin B receptors to the calcium pump and phospolipase C via Gsand Gq in rat liver. J Biol Chem 1994;269:1845-51.138. Jouneaux C, Goldsmith P, Hanoune J, Lotersztajn S. Endothelin inhibits the calciumpump and stimulates phosphoinositide phospholipase C in liver plasma membranes viatwo different G proteins, Gs and Gq. J Cardiovasc Pharmacol 1993; 22(Suppl 8):S158-60.139. Sokolovsky M. Endothelin receptors in rat cerebellum: activation of phospho-inositidehydrolysis is transduced by multiple G-proteins. Cell Signall 1992;5:473-83.140. Galron R, Bdolah A, Kloog Y, Sokolvsky M. Endothelin/ sarafotoxin receptor inducedphosphoinositide turnover: Effects of pertussis and cholera toxins and of phorbol ester.Biochem Biophys Res Commun 1990;171:949-54.141. Baldi E, Musial A, Kester M. Endothelin stimulates phosphatidylcholine hydrolysisthrough both PLC and PLD pathways in mesangial cells. Am J Physiol1994;266:F957-65.142. Kester M, Simonson MS, MxDermott RG, Baldi E, Dunn MJ. Endothelin stimulatesphosphatidic acid formation in cultured rat mesangial cells: Role of a protein kinase C-regulated phospholipase D. J Cell Physiol 1992;150:578-85.143. Schramek H, Wang Y, Konieczkowski M, Rose PM, Sedor JR, Dunn MJ. Endothelin-1 stimulates cytosolic phospholipase A2 in Chinese hamster ovary cells stably116

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