medulla. Am J Physiol 2002;283:H1811-18.95. Mukoyanna M, Nakajima M, Horiuchi M, Sasamura H, Pratt RE, Dzau VJ. Expressioncloning of type-2 angiotensin II receptor reveals a unique class of 7-transmembranereceptors. J Biol Chem 1993;268:24539-42.96. Ozono R, Wang ZQ, Moore AF, Inagami T, Siragy HM, Carey RM. Expression of thesubtype-2 angiotensin II (AT 2 ) receptor protein in the rat kidney. Hypertension1997;30:1238-46.97. Wang ZQ, Moore AF, Ozono R, Siragy HM, Cary RM. Immunolocalization ofsubtype 2 angiotensin II (AT 2 ) receptor protein in rat heart. Hypertension 1998;32:78-83.98. Matrougui K, Louframi L, Heymes C, Levy BI, Henrion D. Activation of AT 2receptors by endogenous angiotensin II is involved in flow-induced dilation in ratresistance arteries. Hypertension 1999;34:659-65.99. Tamura M, Tukagi T, Howard EF, Landon EJ, Steimle A, Tanner M, Meyers PR.Induction of angiotensin II subtype-2 receptor-mediated blood pressure regulation insynthetic diet-fed rats. J Hypertens 2000;18:1239-46.100. Siragy HM, Carey RM. The subtype-2 (AT 2 ) angiotensin II receptor regulates renalguanosine cyclic 3´, 5´ monophosphate and AT 1 receptor-mediated prostanglandine E 2production in conscious rats. J Clin Invest 1996;97:1978-82.101. Siragy HM, Carey RM. The subtype-2 (AT 2 ) angiotensin II receptor mediates renalproduction of nitric oxide in conscious rats. J Clin Invest 1997;100:264-9.102. Suzuki J, Iwai M, Nakagami H, Wu L, Chen R, Sugaya T, et al. Role of angiotensinII-regulated apoptosis through distinct AT 1 at AT 2 receptors in neointimal formation.Circulation 2002;106:847-53.103. Santos RA, Campagnole-Santos MJ, Andrade SP. Angiotensin (1-7): an update.Regul Pept 2000;91:45-62.104. Paula RD, Lima CV, Khosla MC. Angiotensin (1-7) potentiates hypotensive effect ofbradykinin in conscious rats. Hypertension 1995;26:1154-9.105. Broshinan KB, Li P, Ferrario CM. Angiotensin (1-7) dilates canine coronary arteriesthrough kinins and nitric oxide. Hypertension 1996;27:523-8.106. Muthalif MM, Benter IF, Uddin MR, Harper JL, Malik KU. Signal transductionmechanisms involved in angiotensin (1-7)-stimulated arachidonic acid release andprostanoid synthesis in rabbit aortic smooth muscle cells. J Phamacol Exp Ther113
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SVEUČILIŠTE U ZAGREBUMEDICINSKI F
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POPIS KRATICAACEangiotenzin konvert
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3. ISPITANICI i METODE.............
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1.1. RENIN ANGIOTENZIN SUSTAV (RAS)
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Slika 2. "Novi" koncept klasičnog
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1.1.1. AngiotenzinogenSupstrat reni
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i renina nađene su i u neferktomir
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Snižena plazmatska aktivnost renin
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Slika 3. Shematski prikaz krvožiln
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Izvanplućna konverzija angiotenzin
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Radovi Osborna i Studera (65,66) i
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Naša su istraživanja pokazala da
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1.1.7. Angiotenzin (1-7)Angiotenzin
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(114,115). Sve je više dokaza za p
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Slika 6. Mehanizam djelovanja endot
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Strukturno vrlo sličan ljudskim en
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afinitetom receptora (135). Cistein
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Uloga endotelina u patofiziologiji
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1.2.3.1. Učinci na kardiovaskularn
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1.2.4.2. Učinci ET-1 na regulaciju
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učinkom prostaglandin E2 relaksira
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subendotelijalnom prostoru. Naime,
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U in vivo uvjetima, neaktivne KC zd
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Molekularnim pristupom u istraživa
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s maksimumom nakon 48 sati (nakon g
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ožiljka. U oba tipa odgovora prisu
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dva inhibitora metaloproteinaza se
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Kao što je već prethodno istaknut
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Sintezu ET-1 među ostalim podstič
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3.1. IspitaniciU istraživanje je u
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