9. L I T E R A T U R A105
1. Marx LS, Maxwell MH. Tigerstedt and the discovery of renin. An historical note.Hypertension 1979;1:384-8.2. Goldblatt H, Lynch J, Hanzal RF, Summerville WW. Studies on experimentalhypertension I. The production of persistent elevation of systolic blood pressure bymean of renal ishemica. J Exp Med 1984;59:347-79.3. Griendling KK, Murphy TJ, Alexander RW. Molecular biology of the reninangiotensinsystem. Circulation 1993;87:1816-28.4. van Kesteren CA, Danser AH, Derkx FH, Dekkers DH, Lamers JM, Saxena PR, et al.Mannose-6-phosphate receptor mediated internalization and activation of prorenin bycardiac cells. Hypertension 1997;30:1389-96.Admi 5. Admiraal PJ, van Kesteren CA, Danser AH, Derkx FH, Sluiter W, Schalekamp MA.Uptak Uptake and proteolytic activation of prorenin by cultured human endothelial cells. JHyper Hypertens 1999;17:621-9.6. Mary I, Ohta Y, Muruta K, Tsukada Y. Molecular cloning and identification of N-acyl-D-glucosamine 2-epimerase from paracrine kidney as renin-binding protein. JBiol Chem 1966;271:16294-9.7. Campbell DJ, Valentin AJ. Identification of vascular renin binding proteins bychemical cross-linking inhibition of binding of renin by renin inhibitors. J Hypertens1994;12:879-90.8. Sealey JE, Catanzaro DF, Lavin TN, Gahnem F, Pitarresi T, Hu-LF, et al. Specificprorenin/renin binding (proBP). Identification and characterization of a novelmembrane site. Am J Hypertens 1996;9:491-502.9. Nguyen G, Delarue F, Berrou J, Rondeau E, Sraer JD. Specific receptor binding ofrenin on human mesangial cells in culture increases plasminogen activator inhibitor-1antigen. Kidney Int 1996;50:1897-1903.10. Nguyen G, Bouzhir L, Delarue F, Rondeau E, Sraer JD. Evidence of a renin receptoron human mesangial cells: effects onPAI1 and cGMP. Nephrologie 1998;19:411-6.11. Nguyen G, Delarue F, Burckle C, Bouzhir L, Giller T, Sraer JD. Pivotal role of therenin/prorenin receptor in angiotensin II production and cellular responses to renin. JClin Invest 2002;109:1417-27.12. Muller DN, Bohlender J, Hilgers KF, Dragnun D, Costerousse O, Menard J, et al.Vascular angiotensin converting enzyme expression regulates local angiotensin II.Hypertension 1997;29:98-104.106
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SVEUČILIŠTE U ZAGREBUMEDICINSKI F
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POPIS KRATICAACEangiotenzin konvert
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3. ISPITANICI i METODE.............
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1.1. RENIN ANGIOTENZIN SUSTAV (RAS)
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Slika 2. "Novi" koncept klasičnog
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1.1.1. AngiotenzinogenSupstrat reni
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i renina nađene su i u neferktomir
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Snižena plazmatska aktivnost renin
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Slika 3. Shematski prikaz krvožiln
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Izvanplućna konverzija angiotenzin
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Radovi Osborna i Studera (65,66) i
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Naša su istraživanja pokazala da
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1.1.7. Angiotenzin (1-7)Angiotenzin
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(114,115). Sve je više dokaza za p
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Slika 6. Mehanizam djelovanja endot
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Strukturno vrlo sličan ljudskim en
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afinitetom receptora (135). Cistein
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Uloga endotelina u patofiziologiji
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1.2.3.1. Učinci na kardiovaskularn
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1.2.4.2. Učinci ET-1 na regulaciju
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učinkom prostaglandin E2 relaksira
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subendotelijalnom prostoru. Naime,
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U in vivo uvjetima, neaktivne KC zd
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Molekularnim pristupom u istraživa
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s maksimumom nakon 48 sati (nakon g
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ožiljka. U oba tipa odgovora prisu
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