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lowest ET-1 concentration were noticed in u serum of patients with low and moderate fibrosis(group I) - median 6,25 pg/mL, range 2,38-11,80 pg/mL, while the highest concentration wasdetermined in patients with liver cirrhosis (group III) - median, range: 18,95, 12,05-59,38pg/mL. ACE serum activity shows emphasized increase in transition of liver fibrosis frompoor to moderate while ET-1 serum concentration shows marked increase in emerging livercirrhosis from moderate fibrosis. Border value of ACE serum activity which separatespatients with poor liver fibrosis from patients with moderate liver fibrosis is 59,0 U/I. Bordervalue of ET-1 serum activity which separates patients with poor and moderate liver fibrosisfrom patients with liver cirrhosis is 12,4 pg/ml. Correlation of ACE serum activity and ET-1serum concentration was examined by Spearman test in correlation range. Analysis showedpositive correlation of these two variables: with increase ACE serum activity there was alsofound increase of ET-1 serum concentration (p=0,004). RI flow through liver artery is thelowest among the patients with lighter form of poor liver fibrosis (group I): - median, range:0,65, 0,32-0,89 among patients with liver cirrhosis, (group III) -median, range: 0,81, 0,71-0,91. TAMV flow in portal vein shows values reversed association to scale of liver disease: ingroup I the highest values of TAMV were found - median, range: 18,60, 14,50-21,30 cm/s. Inpatients with heavier form of liver illness and cirrhosis (group III), TAMV values were thelowest - median, range: 12,50, 7,50-17,20 cm/s. ET-1serum concentrations showed positivecorrelation with RI ( p