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Former research showed elevated values of ACE serum activity and ET-1 serumconcentration in liver cirrhosis. Experiments also proved elevated ACE serum activity inchronic hepatitis, except for ET-1. There is no data in literature due to interaction betweenACE and ET-1, neither their relationship with Doppler determined parameters hemodynamicstatus in blood circulation of patients with chronic liver diseases which was the subject of thisinvestigation.The research included all together 70 patients divided due to pathohistologicalexamination of biopsy obtained liver tissue divided in three groups. In Group I were includedpatients with liver steatosis, which showed pore fibrosis; group II, contained patients withalcohol and chronic virus hepatitis and primary biliary cirrhosis (PBC), diseases whichshowed moderate fibrosis and group III, were patients with alcohol liver disease on whichsamples of liver tissue prevailated cirrhosis. ACE serum activity was determined by OlympusAU 2700, kit «Infnity TM ACE Liquid Stable Reagent» for determine angiotensin convertingenzyme company Thermo Electron Corporation was used. This procedure of determing ACEserum activity was based on reaction described by Holmquist and associates.Results were expressed in units per liter (U/L). ET-1 serum concentration wasdetermined by ELISA test using reagens ASYBUF for ET-1. Results were expressed inpg/ml of serum.Experiment results showed increase of ACE and ET-1 serum activity in all patientswith various stages of chronic liver lesions what correlates with previous papers. Increase ofACE and ET-1 serum activity in patients is proportional to stage liver disease. The lowestACE activity were found in patients with liver steatosis and poor fibrosis (group I) - median,range: 57, 16-94 IU/L, while in patients with most severe liver fibrosis – cirrhosis (group III)ACE activity was the highest - median, range: 89, 65-139 IU/L. ET-1 serum concentrationalso shows distribution which follows stage of illness, similar as ACE serum activity. The103