Priprema 11.2012.fh11 - Državni zavod za intelektualno vlasništvo

3588 HR - Patenti - Hrvatski glasnik intelektualnog vlasništva 19, 2012, 11, 3513 – 3661(51) MKP (10) HR P20120833 T1C07D 401/10 (2006.01)(11) P20120833 (46) 30.11.2012.(21) P20120833T (22) 15.10.2012.(86) PCT/EP2006007390 24.07.2006.(96) EP 06776430.8 24.07.2006.(87) WO2007012479, 01.02.2007.(97) EP 1907374, 09.04.2008. 200815, En(97) EP 1907374, 22.08.2012. 201234, En(31) 0515381 (32) 26.07.2005. (33) GB0611469 09.06.2006. GB(54) DERIVATI BENZILPIPERAZINA, KORISNI U LIJEČENJUGASTROINTESTINALNIH POREMEĆAJABENZYLPIPERAZINE DERIVATIVES USEFUL FOR THETREATMENT OF GASTROINTESTINAL DISORDERS(73) GLAXO GROUP LIMITED, Glaxo Wellcome House, BerkeleyAvenue, Greenford, UB6 0NN Middlesex, GB(72) Christopher Norbert Johnson, GlaxoSmithKline , New FrontiersScience Park South, Third Avenue, Harlow, Essex CM19 5AW, GBDavid Timothy MacPherson, GlaxoSmithKline, New FrontiersScience Park South, Third Avenue, Harlow, Essex CM19 5AW, GBSteven James Stanway, GlaxoSmithKline, New Frontiers SciencePark South, Third Avenue, Harlow, Essex CM19 5AW, GBGeoffrey Stemp, GlaxoSmithKline, New Frontiers Science ParkSouth, Third Avenue, Harlow, Essex CM19 5AW, GBMervyn Thompson, GlaxoSmithKline, New Frontiers Science Park,South Third Avenue, Harlow Essex CM19 5AW, GBSusan Marie Westaway, GlaxoSmithKline, New Frontiers SciencePark, South Third Avenue, Harlow Essex CM19 5AW, GB(74) Hraste & Partneri odvjetničko društvo, Zagreb, HR(57) Spoj formule (I), ili njegova farmaceutski prihvatljiva sol:naznačen time što:A je fenil ili 6-eročlani heteroarilni prsten, izborno supstituiran shalogenom, C (1-4) alkilom ili C (1-4) alkoksi;R 1 i R 2 su neovisno H ili C (1-4) alkil;R 3 je fenil ili je izborno supstituiran s jednim do dva supstituenta koje sebira između fluora, cijano, trifluormetila i metoksi;X je (CR 4 R 5 ) n ;n je 1 ili 2;Y je NH, O ili CH 2 ;R 4 i R 5 se neovisno bira između vodika i C (1-4) alkila.Patent sadrži još 13 patentnih zahtjeva.(51) MKP (10) HR P20120824 T1C07D 403/14 (2006.01)A61K 31/506 (2006.01)A61P 35/00 (2006.01)(11) P20120824 (46) 30.11.2012.(21) P20120824T (22) 15.10.2012.(86) PCT/GB2006003978 26.10.2006.(96) EP 06794902.4 26.10.2006.(87) WO2007049041, 03.05.2007.(97) EP 1945631, 23.07.2008. 200830, En(97) EP 1945631, 08.08.2012. 201232, En(31) 731299 P (32) 28.10.2005. (33) US803061 P 24.05.2006. US(54) DERIVATI 4-(3-AMINOPIRAZOL) PIRIMIDINA ZA UPORABUKAO INHIBITORI TIROZIN KINAZE U LIJEČENJU KARCINOMA4- (3-AMINOPYRAZOLE) PYRIMIDINE DERIVATIVES FOR USEAS TYROSINE KINASE INHIBITORS IN THE TREATMENT OFCANCER(73) AstraZeneca AB, 151 85 Södertälje, SE(72) Xiaomei Feng, AstraZeneca R & D, Boston 35 Gatehouse Drive,02451 Waltham, MA, USHuiping Guan, AstraZeneca R & D, Boston 35 Gatehouse Drive,02451 Waltham, MA, USYing Kan, 555 Zuchongzhi Lu Building 3, 201203 Shanghai, CNStephanos Ioannidis, AstraZeneca R & D Boston 35 GatehouseDrive, 02451 Waltham, MA, USBo Peng, AstraZeneca R & D, Boston 35 Gatehouse Drive, 02451Waltham, MA, USMei Su, AstraZeneca R & D, Boston 35 Gatehouse Drive, 02451Waltham, MA, USBin Wang, Array BioPharma Inc, 2620 Trade Centre Ave, 80501Longmont, CO, USTao Wang, AstraZeneca R & D Boston, 35 Gatehouse Drive, 02451Waltham, MA, USHai-Jun Zhang, AstraZeneca R & D Boston 35 Gatehouse Drive,02451 Waltham, MA, US(74) PRODUCTA d.o.o., Zagreb, HR(57) Spoj formule (I):ili njegova farmaceutski prihvatljiva sol,naznačen time da:R 1 je odabran iz skupine koja sadrži C 1-6 alkil, C 1-6 alkoksi, 3-5-članikarbociklil i N,N-(C 1-6 alkil) 2 amino, pri čemu R 1 može proizvoljno bitisupstituiran na ugljiku sa jednim ili više R 6 ;R 2 je odabran iz skupine koja sadrži vodik, halo, nitro, i C 1-6 alkil, pri čemuR 2 može proizvoljno biti supstituiran na ugljiku sa jednim ili više R 8 ;R 3 je odabran iz skupine koja sadrži vodik, fluoro, kloro, bromo, N-metil-N-mezilamino i morfolino;R 4 je C 1-6 alkil;R 5 je halo;R 6 je halo;R 8 je halo; in= 1.Patent sadrži još 14 patentnih zahtjeva.(51) MKP (10) HR P20120835 T1C07D 417/04 (2006.01)C07D 403/04 (2006.01)C07D 413/04 (2006.01)C07D 407/14 (2006.01)A61K 31/541 (2006.01)A61P 25/28 (2006.01)(11) P20120835 (46) 30.11.2012.(21) P20120835T (22) 16.10.2012.(86) PCT/DK2007000351 10.07.2007.(96) EP 07764480.5 10.07.2007.(87) WO2008006372, 17.01.2008.(97) EP 2057153, 13.05.2009. 200920, En(97) EP 2057153, 12.09.2012. 201237, En(31) 200600951 (32) 10.07.2006. (33) DK819855 P 10.07.2006. US(54) (3-ARIL-PIPERAZIN-1-IL) DERIVATI 6,7-DIALKOKSIKINAZOLINA, 6,7-DIALKOKSIFTALAZINA I 6,7-DIALKOKSIIZOKINOLINA(3-ARYL-PIPERAZIN-1-YL) DERIVATIVES OF 6,7-DIALKOXYQUINAZOLINE, 6,7- DIALKOXYPHTALAZINE AND 6,7-DIALKOXYISOQUINOLINE(73) H. Lundbeck A/S, Ottiliavej 9, 2500 Valby-Copenhagen, DK(72) Jan Kehler, Nymollevej 28, 2800 Lyngby, DK(74) ZMP IP d.o.o., Zagreb, HR(57) Spoj strukture IISSN 1847-3024