Supplementum 1+2/2010 - Společnost pro pojivové tkáně

minary report. J Bone Joint Surg Am., 1949, 31,464–478.3. Čulík, J., Mařík I. Nomogramy pro určovánítibiofemorálního úhlu (pokroky ve výzkumu,diagnostice a terapii), Pohybové ústrojí.Praha. 2002, roč. 9, č. 3–4, s. 81–89.4. Dirbáková S, Petrášová Š, ZemkováD, Mařík I. Noninvasive methods of tibiofemoralangle assessment in clinical practice,Pohybové ústrojí, 15, 2008 Suppl, No. 1–2,p. 130–134.5. Karski J, Kalakucki J, Karski T etal. The value of surgical release of the iliotibialband in treatment of idiopathic valgus deformityof the knee joint and habitual patella subluxationin children and adolescents. Pohybovéústrojí 14, 2007, No. 1-2, p. 87–93.6. Macnicol MF, Pattinson R.Epiphyseodesis in the Management of LegLength Discrepancy. Seminars in Orthopaedics(the Princess Margaret Rose OrthopaedicHospital, Edinburgh), 7, 1992, No. 3, p. 201-206.7. Marik I, Culík J, Cerny P, Zemkova D,Zubina P, Hyankova E. New Limb Orthoseswith High Bending Pre-Stressing. Orthopädie-Technik Quarterly, English edition III/2003,p. 7–12.8. Mařík I. Antropometrické metody využívanépři objektivizaci proporcionality a nestejnédélky končetin. In. Mařík I. Systémové,končetinové a kombinované vady skeletu: diagnostické,terapeutické a biomechanické aspekty,Pohybové ústrojí 7, 2000, No. 2–3, p. 81–215.9. Novais E, Stevens PM. HypophosphatemicRickets: The Role of Hemiepiphysiodesis.J Pediatr Orthop, 26, 2006, No. 2, p. 238–244.10. Stevens PM, Pease F. Hemiepiphysiodesisfor Posttraumatic Tibial Valgus. J Pediatr Orthop,26, 2006, No. 3, p. 385–392.11. Zemková D, Mařík I. Prediction of theleg shortening and indication of orthopedictreatment at children. Pohybové ústrojí, 14,2007, No. 1–2, p. 147–156.Abstrakt –perspektivní původní práceSimulation of theInfluence of DynamicLoading on Treatment ofDiseases Related to BoneRemodellingKlika V., Maršík F., Mařík I.Keywords: bone remodelling, dynamicloading, RANKL-RANK-OPG chainIntroductionRemodelling of skeleton is a complexprocess performed by the coordinatedactivities of osteoblasts and osteoclasts.Osteoblasts originate from pluripontentmesenchymal stem cells, which also giverise to chondrocytes, muscle cells, adipocytesand stromal bone marrow cells andare the cells responsible for the synthesisof the bone matrix. Osteoclasts are derivedfrom hemopoietic stem cells of themonocyte-macrophage lineage and are theonly cells capable of resorbing mineralisedbone. It is generally concluded the osteoclastsresorb bone during growth, modellingand remodelling. The interactions betweenosteoblasts and osteoclasts, which guaranteea proper balance between bone gainand loss, is known as coupling. The birthand death of osteoblasts and osteoclasts arecontrolled by local factors such as cytokines,growth factors and prostaglandins thatare produced by skeletal and non-skeletaltissues. The effects of these factors can bemediated through autocrine, paracrine oreven endocrine signal pathways, althoughfactors produced by skeletal tissue and storedin bone may have more direct effects.ambul_centrum@volny.cz219