Nikotin Bandı
Nikotin Bandı
Nikotin Bandı
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Klinik Etkinlik<br />
• Randomize çift kör çok merkezli plasebo kontrollü (12<br />
hafta) varenicline plaseboya oranla 4 kat<br />
• Randomize çift kör çok merkezli bupropion kontrollü (12<br />
hafta) varenicline bupropiona oranla 2 kat<br />
• 1. yılın sonunda bırakmış kalma<br />
Vareniklin % 23<br />
Bupropion %15<br />
Plasebo % 9<br />
• Vareniklin plaseboya göre 2.5, bupropiona göre 1.7 kat<br />
yüksek<br />
*Gonzales D, et al. Varenicline, an 42 nicotinic acetylcholine receptor partial agonist, vs sustained-release<br />
bupropion and placebo for smoking cessation: a randomized controlled trial. JAMA. 2006;296:47–55.<br />
*Jorenby DE, et al. Efficacy of varenicline, an 42 nicotinic acetylcholine receptor partial agonist, vs<br />
placebo or sustained-release bupropion for smoking cessation: a randomized controlled trial. JAMA.<br />
2006;296:56 – 63.
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