koah akut atağında farklı steroid dozlarının solunum fonksiyonları ...

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8. SUMMARY
Aims:
İn this study, effects of 1 mg/kg/day versus 2 mg/kg/day prednisolone on
blood gas analysis respiratory functions, dyspnea score and long-term quality of life
has been compared in patients with acute attack of chronic obstructive pulmonary
disease (COPD).
Material- methotds:
A total of 32 patients presenting with acute severe or very-severe COPD
attack were included. Patients were randomized to receive 1 mg/kg/day (n=16) or 2
mg/kg/day (n=16) prednisolone, in addition to combined short acting β 2 -agonist,
ipratropiumbromide nebulised therapy, theophilline, mucolityc, antibiotic and
oxygen treatment. The dosage of steroid has been decreased gradually and weaned of
at day 10.
Blood was drawn at the baseline, at 12-, 24-, 36-, 48-hour, at 3-, 5- and at 10-
day of the treatment for blood gas analysis. Baseline, 3- and 10-day and 3-month
respiratory functions were performed. Baseline, 3- and 10-day Borg dyspnea scores
were recorded. Baseline and 3- month SGRQ scores were recorded. A 6-minute walk
test was performed at discharge and at 3-month.
Results:
İn the both groups, an increase in PaO 2 and pH, and a decrease in PaCO 2 was
observed as the duration of the treatment increased. However, no statistical
differences were found between the two-groups with regard to any parameters of the
blood gas analysis in the blood drawn at the same time frame (all p>0.05)
At the end of the treatment, Borg dyspnea score were decreased in the both
groups. However, no significant difference was observed between the groups
(p>0.05).
When we compared the 3-month SGRQ with the baseline questionnaire, no
statistically significant differences were observed with respect to symptom, activity,