GİRİŞ VE AMAÇ

EXPRESSION OF E-CADHERIN AND CD10 IN PROSTATIC
ADENOCARCINOMAS
SUMMARY
Prostate cancer is the most common malignancy among men, with a higher
incidence over the age of 50.
The small size of material in needle biopsies used for diagnosis of the prostate
cancer coupled with the detectability of increasingly higher number of welldifferentiated
cancers by the help of new methods make it more difficult for a
pathologist to establish a diagnosis of prostate cancer. In addition to routine methods,
some supportive methods such as immunohistochemistry are required. The antibodies
used in our study are E-cadherin and CD10.
In our study, we examined 171 prostate biopsy materials sent to our Division
between 1986 and 2005.
Gleason grading was performed to determine the histological grade of the
prostate adenocarcinomas, and Gleason scores of tumours were determined. The cases
were stained with the antibodies, CD10 and E-cadherin. The studies with CD10, on the
basis of each parameter of Gleason score, demonstrated no staining in the cases with
Gleason score 2-4 (low grade). Staining was seen in the 8-10.5 % of the cases with
Gleason score 5-7 (intermediate grade) and in the 89.5 - 92 % of the cases with
Gleason score 8-10 (high score).
In the studies with CD10, CD10 staining was not seen in prostate tumours with
glandular pattern. However, it was seen in the solid prostate tumours and the prostate
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