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Antibiotikaprofylax vid kirurgiska ingrepp - SBU

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Table 4.14.7 Antibiotic prophylaxis and different medical conditions.<br />

Author<br />

Year<br />

Reference<br />

Country<br />

Study<br />

design<br />

Population<br />

characteristics<br />

Intervention<br />

Method<br />

Number indi<strong>vid</strong>uals<br />

Results outcome 1 intervention<br />

Study quality and relevance<br />

Comments<br />

Lockhart<br />

2007<br />

[29]<br />

USA<br />

Systematic<br />

review<br />

A systematic review<br />

of 8 selected medical<br />

conditions and e<strong>vid</strong>ence<br />

for antibiotic<br />

prophylaxis in case<br />

of dental treatment/<br />

surgery<br />

The following conditions were<br />

reviewed:<br />

1. Cardiac native heart valve<br />

disease, prosthetic heart valves<br />

and pacemaker<br />

2. Hip, knee and shoulder<br />

prosthetic joints<br />

1. Cardiac native heart valve disease:<br />

Class III, Level C. Prosthetic heart valves:<br />

Class IIb,Level<br />

C. Pacemaker: Class III, Level C<br />

2. Hip, knee and shoulder prosthetic joints:<br />

Class III, Level C<br />

3. Renal dialysis shunts: Class III, Level C.<br />

High<br />

Very good and complete systematic<br />

review. No data retrieved possible<br />

to use in meta-analysis. All articles found,<br />

formed the base for classification according<br />

to ACC/AHA regarding the e<strong>vid</strong>ence<br />

for antibiotic prophylaxis<br />

3. Renal dialysis shunts<br />

4. Cerebrospinal fluid (CSF)<br />

shunts<br />

4. Cerebrospinal fluid (CSF) shunts:<br />

Class III, Level C<br />

5. Vascular grafts: Class III, Level C<br />

5. Vascular grafts<br />

6. Immunosuppression secondary<br />

to cancer and cancer treatment<br />

7. Systemic lupus erythematosus<br />

(SLE)<br />

8. Type 1 diabetes mellitus<br />

6. Immunosuppression secondary to<br />

cancer and cancer treatment: Class IIb,<br />

Level C<br />

7. Systemic lupus erythematosus (SLE):<br />

Class III, Level C<br />

8. Type 1 diabetes mellitus: Class III,<br />

Level C<br />

ACC = American College of Cardiology; AHA = American Heart Association<br />

550 antibiotikaprofylax <strong>vid</strong> <strong>kirurgiska</strong> <strong>ingrepp</strong> KAPITEL 4 • den systematiska litteraturöversikten<br />

551

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