Antibiotikaprofylax vid kirurgiska ingrepp - SBU

Table 4.6.2 continued
Author
Year
Reference
Country
Study
design
Population
characteristics
Intervention
Method
Number individuals
Control
Number
individuals
Results
Withdrawal
Drop outs
Study quality
and relevance
Comments
Huether
2002
[6]
USA
RCT
Clean skin cancer resection,
followed by flap reconstruction
in local anestesia.
n=1 030 (473 female,
557 male)
Wound infection 5–8 days
post-op when sutures were
taken
I: Clindamycin was
given together with local
anesthesia in the area
surrounding the lesion
(452 pts; 598 lesions)
C: No antibiotics
given, just local
anestesia (458 pts;
574 lesions)
Wound score
I: 0.19.
C: 0.35; p=0.20
Wound infection
score ≥4
I: 6 wounds (1%)
C: 23 wounds (4%)
p=0.001
Positive wound culture
I: 4 wounds
4/598 (0.07%)
C: 14 wounds
14/574 (2.4%)
p=0.02
1 172 surgical
wounds were
included out of
1 253 analyzed=
93.5 %. Drop out
6.5% because not
eligible for the
study
Moderate
Wound score
0–7; 4 or more
was defined as
infection
Ma
1989
[3]
China
RCT
Clean skin surgery, excision
of skin and subcutaneous
tissue due to hyperhidrosis,
drain 48 h
n=42; 2 axillary operations
per patient, in total 84 wounds
I: Cloxacillin 500 mg po
30 pre-op + 1 dose post-op.
17 pts, 34 wounds.
Male/female ratio 1:1.8
Mean age 21.6 years
C: Placebo
(25 pts, 50 wounds)
Male/female ratio
1:2.6
Mean age 23.8 years
Surgical complication
I: 4/34 (12 %);
1 infection. All healed
by conservative treatment.
No infections.
Fever index 0.29
degree-hours
C: 3/50 (6%), healed
by conservative treatment.
No infections
(ns). Fever index 0.31
degree-hours (ns)
Culture from drain
I: 12/34 wounds (35%)
C: 37/50 wounds (74%)
p