Antibiotikaprofylax vid kirurgiska ingrepp - SBU

Table 4.4.12 Induced abortion.
Author
Year
Reference
Country
Study
design
Population
characteristics
Intervention
Method
Number individuals
Control
Number individuals
Results
Withdrawal
Drop outs
Study quality
and relevance
Comments
Sawaya
1996
[57]
USA
Metaanalysis
Review of RCT,
1966–1994,
12 studies.
n=5 188
I: Any antibiotics C: Placebo Postabortal infection
RR 0.58
(95% CI 0.47–0.71)
Moderate
Only Medline,
no other databases,
many studies
included are low
quality studies
Sörensen
1992
(in Sawaya 1996)
[67]
RCT
1st trimester abortion.
n=432
I: Erythromycin 500 mg x 2
for 7.5 days (n=189)
C: Placebo (n=189) Pelvic inflammation
disease
I: 20/189 (11%)
C: 30/189 (16%)
p=0.13
54 excluded
after randomisation
(12%),
reason given
Moderate
All, except for
54 women had
follow-up, visit,
telephone or
mail, good
internal validity
Levallois
1988
(in Sawaya 1996)
[66]
Canada
RCT
Abortion by suction
curretage
I: Chlamydia negative doxycycline
100 mg before and 200 mg
30 min after abortion (n=503),
chlamydia positive (n=33)
C: Chlamydia negative:
placebo (n= 499)
Chlamydia positive:
placebo (n=42)
Pelvic infection
I: 2/502 (0.4%)
(negative)
1/33 (3%) positive
C: 15/497 (3.0%)
(negative) p=0.001
11/42 (26.2%)
p=0.009
3/1 077 (0.3%) Moderate
No power calculation,
side
effects reported
Henriques
1994
[69]
Denmark
RCT Low risk: n=549
High risk (young
age, positive culture
of C. trachomatis or
N. Gonorrhoeae or
bacterial diagnosis:
n=237
I: Low risk: Ceftriaxone
1 g iv pre-op (n=275)
High risk: Ceftriaxone
(n=108)
C: Low risk: No antibiotics
(n=274)
High risk: Iv ampicillin
1 g + metronidazole
500 mg pre-op, followed
by oral doses of metronidazole
500 mg and
pivampicillin 500 mg
3 times administrated
for 4 days (n=129)
Postabortal infection
I: Low risk: 2 (0.7%)
high risk: 4 (3.7%)
C: Low risk:
10 (3.6%)
high risk: 6 (4.7%)
sign for low risk,
p