Antibiotikaprofylax vid kirurgiska ingrepp - SBU

Table 4.3.2 continued
Author
Year
Reference
Country
Study
design
Population
characteristics
Intervention
Method
Number individuals
Control
Number
individuals
Results
Withdrawal
Drop outs
Study quality
and relevance
Comments
Edwards
1993
[15]
USA
RCT
Peripheral vascular
surgery
I: Cefazolin 2 g at induction,
1 g every 4 h pre-op and
every 6 post-op x 4 (n=362)
C: Cefamandole 2 g
at induction, 1 g every
2 h pre-op and every
4 h x 6 (n=348)
Wound infection
Grade I–III
I: 7/362 1.9%
C: 11/348 3.9% ns
Costs
I: Per pt
85.78 US dollar
C: Per pt
19.20 US dollar
20% (187) Moderate
High rate of drop
outs. No power calculation.
The danger
of the groin was
noted. All infections
occurred in the groin.
3.6% infection rate
compared to 0.5%
for patients without
groin incision
Hall
1998
[9]
Australia
RCT
Peripheral vascular
surgery comparing single
dos vs multiple doses.
n=302
I: Ticarcillin 3 g/clavulanate
0.1 g iv at induction
+ same dose after 3 h
pre-op (n=153)
Pre-op same as above
+ same dose every 6 h
until all lines removed
but