Antibiotikaprofylax vid kirurgiska ingrepp - SBU

Table 4.2.2 continued
Author
Year
Reference
Country
Study
design
Population
characteristics
Intervention
Method
Number individuals
Control
Number
individuals
Results
Withdrawal
Drop outs
Study quality
and relevance
Comments
Giercksky
1982
[23]
Norway
RCT
Pts undergoing elective
colorectal surgery.
Female/male: 107/127.
Mean age 62 years.
n=240
I: Tinidazole 800 mg and
doxycycline 200 mg 1 h
before operation and
in total of 5 days (n=116)
C: Tinidazole
160 mg + doxycycline
400 mg 2 h
before operation.
Single dose (n=118)
Wound infection
I: 6 pts
C: 0 pts
Intraabdominal/pelvic
abscess
I: 5 pts
C: 4 pts
6 pts were
excluded
Moderate
Not blinded.
Randomisation
not described
Sepsis
I: 2 pts
C: 0 pts
Ishida
2001
[20]
Japan
RCT
Pts undergoing colorectal
surgery
Intervention:
Female/male: 29/42.
Mean age 65 years
Control:
Female/male: 25/47.
Mean age 62 years
n=146
I: Mechanical bowel preparation
+ 1 g cefotiam at 0,
end of operation, 1 g x 2
for additional 2 days (n=71)
C: Mechanical
bowel preparation
+ 1 g cefotiam at 0,
end of operation,
1 g x 2 for additional
2 days +
oral kanamycin
2 g/day + erythromycin
1.6 g/day
divided in 4 doses
daily for 2 days
before surgery
(n=72)
SSI including incisional
infections and organspace
infections
I: 23.9%
C: 11.1% p=0.04
Distant infections
I: 8.5%
C: 5.6% p=0.36
MRSA infection
I: 5.6%
C: 11.1% p=0.19
Remote infections
caused by MRSA
I: 2.8%
C: 9.7% p=0.086
3 pts were
excluded
Moderate
SSI less in the
group of pts
receiving oral
antibiotics.
However, MRSA
distant infections
were higher (sign)
in this group. The
trial goes against
all other studies
due to 3 days of
iv antibiotics was
used. In metaanalysis
[1]
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