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AGRESIVITATEA. PENTRU UN MODEL NEUROBIOLOGIC<br />

T. Udriştoiu, D. Marinescu, G. Bă<strong>de</strong>scu, A. Miloşescu<br />

Clinica Universitară <strong>de</strong> Psihiatrie Craiova<br />

Rezumat<br />

Agresivitatea pacienţilor cu tulburări psihice implică atât mo<strong>de</strong>le psihosociale, cât şi<br />

biologice.<br />

Cercetările din ultimele <strong>de</strong>cenii au <strong>de</strong>monstrat relaţia agresivitate - factori<br />

constituţionali şi <strong>de</strong> mediu, utilizându-se observaţia comportamentului, studii în<br />

câmp, meto<strong>de</strong> experimentale şi scale <strong>de</strong> evaluare.<br />

În neuro-anatomia agresivităţii a fost <strong>de</strong>monstrată intervenţia hipotalamusului,<br />

amigdalei şi cortexului prefrontal. A fost <strong>de</strong>monstrată corelaţia între agresivitate şi<br />

impulsivitate, principala cauză a tulburărilor <strong>de</strong> control a pulsiunilor fiind<br />

consi<strong>de</strong>rată alterarea transmisiei serotoninergice. În comportamentul hetero-agresiv<br />

par a fi implicaţi toţi neuromediatorii, alături <strong>de</strong> sistemul endocrin.<br />

Cuvinte cheie: agresivitate, neuroanatomie, nerurochimiei.<br />

AGGRESSIVENESS. A NEUROBIOLOGICAL MODEL<br />

Abstract<br />

The aggressiveness <strong>of</strong> the patients with psychiatric disor<strong>de</strong>rs involves both<br />

psychosocial and biological mo<strong>de</strong>ls.<br />

During the last <strong>de</strong>ca<strong>de</strong>s, the research has proven the relation between<br />

aggressiveness on one hand and the constitutional and environmental factors on the<br />

other hand. For that, the observation <strong>of</strong> behaviour, in-field studies, experimental<br />

methods and evaluation scales have been used.<br />

In the neuro-anatomy <strong>of</strong> aggressiveness are involved the hypothalamus, the amigdala<br />

and the prefrontal cortex. The correlation between aggressiveness and impulsiveness<br />

has been also proven, the dysfunction <strong>of</strong> the serotoninic transmission being<br />

consi<strong>de</strong>red the main cause for the alteration <strong>of</strong> the impulse control. Besi<strong>de</strong> the<br />

endocrine system, every neurotransmission pathway is involved in the heteroaggressive<br />

behaviour.<br />

Key words: aggressiveness, neuroanatomy, neurochemistry.<br />

În perspectiva psihopatologiei clasice şi a cercetărilor actuale neurobiologice, agresivitatea<br />

pacienţilor cu tulburări psihice se situează pe o poziţie duală implicând mo<strong>de</strong>le psihosociale <strong>de</strong><br />

inspiraţie comportamentală şi mo<strong>de</strong>le biologice susţinute <strong>de</strong> posibilitatea controlului agresivităţii<br />

prin medicaţie psihotropă.<br />

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