2011, nr. 1 - Academia de Ştiinţe a Moldovei

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Rezumat
Căile din creierul nostru sunt reţele de comunicare
și starea lor fi zică infl uenţează efi cienţa comunicaţiei și,
respectiv, manifestarea comportamentală. Schimbările din
structura substanţei albe, datorită proceselor de plasticitate
și adaptare la factorii extrinseci și intrinseci, pot amplifi ca
sau pot diminua efi cienţa comunicării, determinând mo-
Buletinul AŞM
difi cări comportamentale. Descărcările epileptice cu certitudine
provoacă și, de asemenea, determină schimbările
secundare din aceste reţele de comunicare, cu reorganizare
funcţională și structurală. Studiile recente atestă schimbări
ale conectivităţii structurale în regiunile epileptogenice și
ariile interconectate. Reţelele talamocorticale ar putea juca
un rol important în cadrul acestei interacţiuni. Articolul
dat prezintă o revizuire a studiilor recente de conectivitate
în epilepsii. Sunt prezentate problemele de conectivitate
structurală și funcţională.
Summary
Th e pathways within our brain are networks of
communication, and their physical condition infl uences
communication’s effi ciency and behaviour performance respectively.
Changes in white matter structure, due to plasticity
and adaptation processes to extrinsic and intrinsic
factors can enhance or diminish communication effi ciency,
determining behavioral changes. Epileptic discharges undoubtedly
arise but also determine secondarily changes in
these communication networks, with both functional and
structural reorganization. Recent studies present changes
of structural connectivity in epileptogenic regions and interconnected
areas. Th alamo-cortical pathway may play an
important role in this interaction. Th is article presents an
overview of recent connectivity studies in epilepsies. Matters
of structural and functional connectivity are presented.
Резюме
Проводящие пути в нашем мозге являются
сетями связи и их физическое состояние влияет
на эффективность связи и, соответственно, на
поведенческие проявления. Изменения в структуре
белого вещества, которые возникают в результате
процессов пластичности и адаптации к внешним и
внутренним факторам, могут усилить или ослабить
эффективность связи, определяя этим поведенческие
изменения. Эпилептические разряды несомненно
провоцируют, но также приводят к вторичным
изменениям в этих сетях связи в виде функциональной
и структурной реорганизации. Последние
исследования показывают изменение структурной
связи в эпилептогенных зонах и связанных с ними
областях. Таламо-кортикальные сети могут играть
важную роль в этом взаимодействии. В данной статье
представлен обзор последних исследований связи в
эпилепсии. Представлены вопросы структурной и
функциональной связи.