2011, nr. 1 - Academia de Ştiinţe a Moldovei

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minat creșterea semnifi cativă a nivelului seric de ßendorfi
ne la 47% pacienţi cu migrenă cronică, iar la
ceilalţi 53% s-a remarcat o diminuare nesemnifi cative
a acestui indice.
3.
La pacienţii trataţi prin stimularea electrică
transcraniană în regim placebo s-a evidenţiat diminuarea
statistic semnifi cativă a intensităţii durerii, fără
o creștere corespondentă semnifi cativă a nivelului ßendorfi
nelor serice.
Bibliografi e
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Buletinul AŞM
15. Лебедев В.П. Транскраниальная электростимуляция.
Экспериментально-клинические исследования.
Сборник статей под ред. д.м.н., проф. В.П.
Лебедева, второе издание, 2-х томное, Санкт-Петербург,
2001, 1045 стр.
Rezumat
Scopul studiului a fost determinarea efi cienţei metodei
de stimulare electrică transcraniană (SET) la pacienţii
cu migrenă cronică (MC). În studiu au fost incluși 62
de pacienţi cu MC: 47 trataţi prin SET în regim curativ și
15 – în regim de placebo activ. Au fost analizate dinamic
până și după tratament atât intensitatea cefaleei (conform
scalei vizuale-analogice), cât și nivelele serice ale ß-endorfi
nelor. Tratamentul prin SET la pacienţii cu MC a redus
considerabil și statistic semnifi cativ intensitatea fenomenului
cefalagic (cu 54,2%); a determinat creșterea semnifi cativă
a nivelului seric de ß-endorfi ne la 47% din pacienţi.
La ceilalţi 53% s-a remarcat o diminuare nesemnifi cativă
a ß-endorfi nelor. La pacienţii trataţi prin SET în regim de
placebo a scăzut statistic semnifi cativ intensitatea durerii,
fără o creștere corespondentă semnifi cativă a nivelului ßendorfi
nelor serice.
Summary
Th e aim of our study was to estimate the effi cency of
transcranial electrostimulation (TES) in acute treatment of
chronic migraine patients vs. placebo. We conducted a study
on 62 patients diagnosed with chronic migraine (CM):
47 of them treated by TES and 15 by an active placebo device.
Dinamic pre- și post-treatament analyses of headache
severity on VAS and serum ß-endorphin levels were performed.
Both treataments, by TES and by active placebo,
leaded to a signifi cant decrease of pain level on VAS (by
54,2%) and to a signifi cant increase of ß-endorphin level
in 47% of patients. By contrast, in the rest of 53% pacients
there was a no signifi cant decrease of ß-endorphin level after
treatment. In patients treated by an active placebo device
there was a signifi cant decrease in pain level without
an correspondent increase of serum ß-endorphin level. So,
TES may be used as a safe non-pharmacologic treatment of
chronic migraine patients, due to its eff ect of pain reducing
and increasing of serum ß-endorphin level.
Резюме
Целью данного исследования было определение
эффективности немедикаментозного метода лечения
больных хронической мигренью (ХМ) путем транскраниальной
электрической стимуляции (ТЭС). В исследование
были включены 62 больных ХМ: 47 б-х, пролеченных
ТЭС в лечебном режиме, и 15 б-х, которым
применялась активная плацебо-ТЭС. Были оценены в
динамике (до и после лечения) интенсивность головной
боли (по данным визуальной аналоговой шкалы)
и уровень ß-эндорфинов плазмы крови. Лечение ТЭС
привел к значительному и статистически достоверному
снижению интенсивности мигренозной цефалгии
(на 54,2%), а также к статистически достоверному
повышению уровня ß-эндорфинов у 47% б-х ХМ. У
остальных 53% больных наметилось незначительное
понижение ß-эндорфинов. У пациентов, которым применялась
плацебо- ТЭС, наблюдалось статистически
достоверное снижение выраженности головной боли,
но без соостветствующего достоверного повышения
концентрации ß-эндорфинов в крови.