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2011, nr. 1 - Academia de Ştiinţe a Moldovei

2011, nr. 1 - Academia de Ştiinţe a Moldovei

2011, nr. 1 - Academia de Ştiinţe a Moldovei

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<strong>Ştiinţe</strong> Medicale<br />

17 . Welch K.M.A. Stroke and migraine – the spectrum<br />

of cause and eff ect. Funct Neurol., 2003; 18:121-126.<br />

18. Moldovanu I., Dodick D.W., Odobescu S. Cefaleele,<br />

durerile faciale și cervicale (diagnostic și tratament). Chișinau,<br />

2007; 520 p.<br />

19. Clasifi carea Internaţională a Tulburărilor Cefalalgice.<br />

Ediţia a doua. Chișinău, 2004, 270 p.<br />

20. Welch K.M.A. Relationship of stroke and migraine.<br />

Neurology, 1994; 44(7):33-36.<br />

21. Leao A.P.P. Spreading <strong>de</strong>pression of activity in the<br />

cerebral cortex. J. Neurophysiol., 1944; 7:359-390.<br />

22.Rose K.M., Carson A.P., Sanford C.P. et al. Migraine<br />

and other headaches: associations with Rose angina and coronary<br />

heart disease. Neurology, 2004; 63:2233-2239.<br />

23. Dreier J.P., Kleeberg J., Alam M., et al. Endothelin-<br />

1-induced spreading <strong>de</strong>pression in. rats is associated with<br />

a microarea of selective neuronal necrosis. Exp. Biol. Med<br />

(Maywood), 2007; 232:204-213.<br />

24. Matijevic N., Wu K.K. Hypercoagulable states and<br />

strokes. Curr. Atheroscler. Rep. 2006; 8:324-329.<br />

25. Sarchielli P., Alberti A., Coppola F. et al. Plateletactivating<br />

factor (PAF) in internal jugular venous blood of<br />

migraine without aura patients assessed during migraine attacks.<br />

Cephalalgia, 2004; 24:623-630.<br />

26. Butler R., Morris A.D., Burchell B., Struthers A.D.<br />

DD angiotensin- converting enzyme gene polymorphism is<br />

associated with endo thelial dysfunction in normal humans.<br />

Hypertension, 1999; 33:1164-1168.<br />

27. Holmer S.R., Bickeboller H., Hengstenberg C. et<br />

al. Angiotensin converting enzyme gene polymor phism and<br />

myocardial infarction: a large association and linkage study.<br />

Int. J. Biochem. Cell Biol, 2003; 35:955-962.<br />

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predisposition to neurological symptoms in lacu nar infarction.<br />

Cerebrovasc. Dis., 2004; 17:273-279.<br />

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of endothelial dysfunction in lacunar infarction and ischaemic<br />

leukoaraiosis. Brain., 2003; 126:424-432.<br />

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the insertion/<strong>de</strong>letion polymorphism of the angio tensin Iconverting<br />

enzyme gene in patients of migraine with aura.<br />

Neurosci. Lett., 2005; 374:129-131.<br />

31. Furchgott R.F., Zawadzki J.V. Th e obligatory role of<br />

endothelial cells in the relaxation of arterial smooth muscle<br />

by acetylcholine. Nature, 1980; 288: 373-376.<br />

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pathophysiol ogy and treatment of migraine. Neurology,<br />

1993; 43(Suppl. 3): S16-20.<br />

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C-Reactive pro tein increased in migraine. Headache, 2004;<br />

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Physiol. Rev., 1998; 78 (1):53-97.<br />

38. Moncada S., Palmer R.M., Higgs E.A. Th e discovery<br />

of nitric oxi<strong>de</strong> as the endogenous nitrovasodilator. Hypertension,<br />

1988; 12(4):365-372.<br />

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and growth. Clin. Exp. Hipertens., [A] 1990;12(5):897-902.<br />

40. Palmer R.M.J., Ashton D.S., Moncada S. Vascular<br />

endothelial cells synthesize nitric oxi<strong>de</strong> from L-arginine. Nature.,<br />

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Rezumat<br />

Rolul migrenei în apariţia afecţiunilor ischemice a<br />

fost presupus încă la sfârșitul secolului XIX. O ipoteză a<br />

riscului mai mare a afecţiunilor ischemice cerebrale și coronariene<br />

la pacienţii migrenoși, însă, a fost formulată doar<br />

la mijlocul anilor ’50 ai secolului trecut. La moment sunt<br />

multiple dovezi, care <strong>de</strong>monstrează această ipoteză. Argumente<br />

convingătoare că persoanele migrenoase prezintă un<br />

risc sporit în <strong>de</strong>zvoltarea unui proces ischemic cerebral sau<br />

coronarian acut, nu au fost, însă, <strong>de</strong>ocamdată prezentate pe<br />

<strong>de</strong>plin, cu toate că publicaţiile din ultimii ani au transformat,<br />

<strong>de</strong> fapt, această ipoteză atractivă în argumente documentate,<br />

cu un grad <strong>de</strong>stul <strong>de</strong> înalt <strong>de</strong> certitudine.<br />

Summary<br />

Th e importance of migraine in the <strong>de</strong>velopment of ischemic<br />

disor<strong>de</strong>rs was suggested as far back at the end f XIX<br />

century. But a hypothesis a higher risk of cerebral ischemic<br />

and coronary diseases in migraineurs patients was formulated<br />

only in the mid-fi ft ies of the past century. Currently<br />

multiple proofs, confi rming this hypothesis, are off ered.<br />

But convincing data about persons with a high risc of <strong>de</strong>velopment<br />

of an ischemic process have not been established.<br />

Nevertheless, the recent year’s publications have actually<br />

transformed this exiting hypothesis into documented arguments<br />

with a high <strong>de</strong>gree of certainty.<br />

Резюме<br />

Предположение о роли мигрени в возникновении<br />

ишемических заболеваний, было сформулировано еще<br />

в конце ХIХ века. Но гипотеза o более высоком риске<br />

ишемических церебральных и коронарных расстройств<br />

у больных мигренью былa сформулированa только в<br />

середине 50-x годов прошлого столетия. В настоящее<br />

время существует множество фактов, которые<br />

подтверждают эту гипотезу. Тем не менее, многие<br />

исследователи считают, что нет ещё убедительных<br />

аргументов, которые доказывали бы повышенный риск<br />

развития ишемических церебральных или коронарных<br />

нарушений у указанных больных, несмотря на то, что<br />

публикации последних лет трансформировали, на наш<br />

взгляд, эту гипотезу в документированную систему<br />

аргументации, с высокой степенью достоверности.

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