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Biotransformarea creşte proporţional cu cantitatea<br />

de medicament liber în plasmă.<br />

Medicamentele cuplate în proporţie mare cu<br />

proteinele plasmatice se elimină lent (ex.<br />

digitalina, fenilbutazona) şi au o durată lungă de<br />

acţiune.<br />

Legarea de proteine este un proces reversibil,<br />

dinamic.

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