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Substantele medicamentoase si majoritatea<br />

compusilor exogeni sau chiar endogeni (ex:<br />

hormoni, bilirubină etc.) se leagă în organ<strong>is</strong>m<br />

de:<br />

► proteinele plasmatice sau<br />

► t<strong>is</strong>ulare.<br />

Se vor forma complexe mari care nu pot<br />

traversa membranele biologice.

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