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Protocol de abordare a durerii toracice in urgenta - Cursul national ...

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<strong>Protocol</strong> <strong>de</strong> <strong>abordare</strong> a <strong>durerii</strong> <strong>toracice</strong> <strong>in</strong> <strong>urgenta</strong>Diana Carmen Cimpoesu 1,3 , Luciana Rotaru 2 , Catal<strong>in</strong> Diaconu 3 ,Ovidiu Petris 1 , Antoniu Petris 1591IntroducereDurerea toracica este un simptom obisnuit si relativ frecvent <strong>in</strong>talnit înserviciile <strong>de</strong> <strong>urgenta</strong> si are cel mai a<strong>de</strong>sea o cauza benigna. In situatia în caredurerea toracica este <strong>de</strong>term<strong>in</strong>ata <strong>de</strong> o patologie cu risc vital tratamentulpacientului trebuie efectuat <strong>de</strong> <strong>urgenta</strong>, imediat dupa <strong>de</strong>butul simptomelor,aceasta <strong>abordare</strong> precoce fi<strong>in</strong>d premisa sca<strong>de</strong>rii mortalitatii (1). Un procentimportant d<strong>in</strong>tre pacientii cu durere toracica <strong>de</strong>term<strong>in</strong>ata <strong>de</strong> o cauza severanu solicita la timp <strong>in</strong>terventia medicala <strong>de</strong> <strong>urgenta</strong> si <strong>de</strong> aceea <strong>in</strong>terventiile<strong>in</strong> scop diagnostic si terapeutic sunt uneori <strong>in</strong>tarziate.Această propunere <strong>de</strong> protocol este facuta conform recomandarilor Ghidului<strong>de</strong> Durere Toracica al Societatii Europene <strong>de</strong> Cardiologie coroborat curecomandarile ulterioare ale societatilor sti<strong>in</strong>tifice europene, americane darşi a celor d<strong>in</strong> Romania (2, 3, 4), referitoare la <strong>in</strong>farctul miocardic acut cu saufara supra<strong>de</strong>nivelare <strong>de</strong> segment ST si <strong>in</strong> concordanta cu posibilitatile actuale<strong>de</strong> diagnostic si tratament în special d<strong>in</strong> cadrul structurilor <strong>de</strong> primireurgente <strong>in</strong> colaborare cu celelalte specialitati medicale. Necesitatea unuiprotocol <strong>de</strong> <strong>abordare</strong> <strong>in</strong> <strong>urgenta</strong> a pacientului cu durere toracica <strong>in</strong> Romaniaa reiesit d<strong>in</strong> existenta unor atitud<strong>in</strong>i variate <strong>in</strong> diverse servicii <strong>de</strong> <strong>urgenta</strong>,ale caror consec<strong>in</strong>te nu sunt <strong>in</strong>tot<strong>de</strong>auna favorabile pacientului. Pe acestfond al problemei, atat M<strong>in</strong>isterul Sanatatii cat si Colegiul Medicilor d<strong>in</strong>Romania si numeroase societati profesionale au aratat necesitatea elabora-1 Universitatea <strong>de</strong> Medic<strong>in</strong>a si Farmacie „Gr. T. Popa” Iasi,2 Universitatea <strong>de</strong> Medic<strong>in</strong>a si Farmacie Craiova,3 UPU-SMURD, Sp. Cl. Ju<strong>de</strong>tean <strong>de</strong> Urgenta „Sf. Spiridon” IasiCimpoesu Carmen Diana, 0722.387670, 0232.276910, dcimpoiesu@yahoo.comUPU-SMURD, Spitalul Sf. Spiridon, bd. In<strong>de</strong>pen<strong>de</strong>ntei nr.1, IasiTimisoara 2009


592rii <strong>de</strong> ghiduri si protocoale pentru <strong>abordare</strong>a standardizata <strong>in</strong> <strong>urgenta</strong>, darcare sa ofere <strong>in</strong> acelasi timp suport gandirii medicale fata <strong>de</strong> problematicacomplexa a fiecarui pacient.Propunerea <strong>de</strong> protocol respecta nivelele <strong>de</strong> evi<strong>de</strong>nta si clasele terapeuticecupr<strong>in</strong>se <strong>in</strong> ghidurile <strong>in</strong>ter<strong>national</strong>e si anume:Clasa I. Metoda diagnostica sau <strong>de</strong> tratament pentru care exista date sigureca aduce beneficii, este utilă si eficienta- „ar trebui aplicata”.Clasa II. Metoda (procedura/tratament) fata <strong>de</strong> care exista divergente <strong>de</strong>op<strong>in</strong>ii <strong>in</strong> priv<strong>in</strong>ta eficacitatii si utilitatii (beneficiului).Clasa IIa. Majoritatea dovezilor <strong>in</strong>cl<strong>in</strong>a spre afirmarea beneficiului/eficacitatiitratamentului - „aplicarea este rezonabila”.Clasa IIb. Exista dovezi conform carora beneficiul este mai mare sau celput<strong>in</strong> egal cu riscul- „aplicarea poate fi luata <strong>in</strong> consi<strong>de</strong>rare”.Clasa III. Metoda <strong>de</strong> tratament care nu si-a dovedit eficienta/beneficiul sichiar poate avea efecte negative – practic o contra<strong>in</strong>dicatie.Nivel A - exista suficient <strong>de</strong> multe studii largi, randomizate, multicentricesi meta-analize.Nivel B - studii <strong>de</strong> mai mici dimensiuni, nerandomizate sau un s<strong>in</strong>gur studiurandomizat.Nivel C - op<strong>in</strong>ii ale expertilor sau dovezi furnizate <strong>de</strong> prezentari <strong>de</strong> caz.In lum<strong>in</strong>a ghidului Societatii Europene <strong>de</strong> Cardiologie (1) <strong>abordare</strong>a pacientuluicu durere toracica poate fi vazuta ca o trecere pr<strong>in</strong>tr-o serie <strong>de</strong>c<strong>in</strong>ci porti: pacientul <strong>in</strong>susi, medicul <strong>de</strong> familie, dispeceratul <strong>de</strong> <strong>urgenta</strong> 112,serviciile medicale <strong>de</strong> <strong>urgenta</strong> d<strong>in</strong> prespital, structurile medicale <strong>de</strong> <strong>urgenta</strong>d<strong>in</strong> spital (fig. 1). In ve<strong>de</strong>rea sca<strong>de</strong>rii timpului <strong>de</strong> <strong>in</strong>terventie <strong>de</strong> <strong>urgenta</strong>pentru salvarea vietii unui pacient cu durere toracica, nu întot<strong>de</strong>auna trebuieparcurse cele c<strong>in</strong>ci porţi, <strong>in</strong>terventia <strong>in</strong>tr-o situatie <strong>de</strong> tipul <strong>in</strong>farctuluimiocardic acut cu supra<strong>de</strong>nivelare <strong>de</strong> segment ST fi<strong>in</strong>d una contratimp, <strong>in</strong>care va lipsi veriga medicului <strong>de</strong> familie si toate celelalte vor fi reduse <strong>in</strong>scopul ajungerii pacientului pe masa <strong>de</strong> angioplastie <strong>in</strong>tr-un <strong>in</strong>terval <strong>de</strong> sub120 m<strong>in</strong> (4). Datele diverselor studii <strong>in</strong>dica diferente <strong>in</strong> ceea ce priveste etiologia<strong>durerii</strong> <strong>toracice</strong> <strong>in</strong> functie <strong>de</strong> locul primei adresari a pacientului (tabelnr 1).Recomandări şi Protocoale în Anestezie, Terapie Intensivă şi Medic<strong>in</strong>ă <strong>de</strong> Urgenţă


Tabel 1. Etiologia <strong>durerii</strong> <strong>toracice</strong> <strong>in</strong> functie <strong>de</strong> prima prezentare a pacientului (1)EtiologieMedic <strong>de</strong>familie (%)Dispecerat (%)Echipajul <strong>de</strong>ambulanta (%)Departamentul <strong>de</strong><strong>urgenta</strong> (%)CardiacaMusculoscheletalaPulmonaraGastro<strong>in</strong>test<strong>in</strong>alaPsihiatricaAlta204345111660646519694543518451456826Prima poarta: Pacientul1. Intarzierea apelarii serviciilor medicale <strong>in</strong> cazul <strong>durerii</strong> <strong>toracice</strong> d<strong>in</strong> momentulaparitiei simptomelor este partea majora d<strong>in</strong> <strong>in</strong>tarzierea totalapana la aplicarea tratamentului pacientului cu durere toracica.2. Factori diferiti: sexul, varsta, statutul social si nivelul <strong>de</strong> educatie, precumsi severitatea simptomelor, <strong>in</strong>fluenteaza <strong>de</strong>cizia pacientului <strong>de</strong> asolicita serviciile medicale.3. Campaniile <strong>de</strong> educatie ale populatiei s-au dovedit a avea un succesmo<strong>de</strong>rat <strong>in</strong> scurtarea timpului pana la <strong>in</strong>ceperea tratamentului (ClasaIIb, Nivel B)593Mesajele catre public: Diagnosticul si tratamentul precoce salveaza vieti• Durerea toracica poate <strong>in</strong>dica o afectiune care amen<strong>in</strong>ta viata.• Simptomele sunt puternic <strong>in</strong>dividualizate si pot apare ca durere retrosternala,senzatie <strong>de</strong> apasare, dispnee, greutate <strong>in</strong> piept sau usor disconfort.• Simptomele pot radia <strong>in</strong> brat, umar, gat sau spate, sau pot <strong>de</strong>buta <strong>in</strong>epigastru.• Aparitia simptomelor poate fi acuta, graduala sau <strong>in</strong>termitenta.• Este important <strong>de</strong> recunoscut aparitia altor simptome-semne care <strong>in</strong>sotescdisconfortul <strong>in</strong> piept pentru a subl<strong>in</strong>ia severitatea <strong>durerii</strong> <strong>toracice</strong>.• Indicatorii unei afectiuni mai put<strong>in</strong> severe sunt: durere (disconfort) carevariaza cu respiratia, pozitia corpului, legatura cu <strong>in</strong>gestia <strong>de</strong> alimente,localizarea precisa <strong>in</strong>tr-o zona sau punct al toracelui, durerea accentuatala palpare.Situaţia este gravă dacă simptomele:• Intrerup activitatea normala• Sunt <strong>in</strong>sotite <strong>de</strong>: transpiratii reci, greata, varsaturi, slabiciune, anxietate/frica.Timisoara 2009


oritate evaluarea pr<strong>in</strong> <strong>in</strong>trebari simple a functiilor vitale: stare <strong>de</strong> constienta,libertatea cailor aeriene, respiratie, circulatie. Ele sunt <strong>de</strong>st<strong>in</strong>ate <strong>in</strong> primulrand pentru a face diferenta <strong>in</strong>tre prioritati la dispecerizare si aplicarea celuimai potrivit tip <strong>de</strong> raspuns pr<strong>in</strong> alocarea unui cod <strong>de</strong> culoare: rosu, galben,ver<strong>de</strong> sau grad <strong>de</strong> <strong>urgenta</strong>: 0, 1, 2, transport medical asistat etc.Un obiectiv secundar specific al dispecerizarii este aplicarea pr<strong>in</strong> telefon aresuscitarii cardiopulmonare care poate creste rata <strong>de</strong> succes pr<strong>in</strong> aplicareamanevrelor <strong>de</strong> resuscitare <strong>de</strong> baza <strong>de</strong> catre martorii unei opriri cardiace,urmand <strong>in</strong>dicatiile la telefon (1,5).596Managementul pacientului cu durere toracica <strong>de</strong> catre dispecer:Informatia <strong>de</strong> la pacienti si martori este a<strong>de</strong>sea limitata si exista un evi<strong>de</strong>ntrisc <strong>de</strong> ne<strong>in</strong>telegere sau <strong>in</strong>terpretare gresita. Volumul apelurilor poatefi <strong>de</strong> asemenea un factor <strong>de</strong> stress, care uneori provoaca ezitari <strong>in</strong> <strong>in</strong>itiereaunor <strong>in</strong>terventii consumatoare <strong>de</strong> timp.Activitatile dispecerilor se centreaza <strong>in</strong> jurul urmatoarelor elemente:- <strong>in</strong>tervievarea apelantului- stabilirea nivelului <strong>de</strong> prioritate- dispecerizarea si directionarea echipajului <strong>de</strong> <strong>urgenta</strong>- oferirea <strong>de</strong> sfaturi si <strong>in</strong>structiuni <strong>in</strong> situatiile cand acestea sunt posibile,<strong>de</strong> exemplu <strong>in</strong>structiunile pr<strong>in</strong> telefon pentru situatiile <strong>de</strong> resuscitarecardiopulmonara cand dispecerul suspecteaza un stop cardiac.Faza I: i<strong>de</strong>ntificarea problemei. In faza <strong>de</strong> i<strong>de</strong>ntificare dispecerul trebuiesa stabileasca daca ajutorul este necesar sau nu. In momentul apelului <strong>de</strong><strong>urgenta</strong> apelantul <strong>de</strong>ci<strong>de</strong> daca <strong>de</strong>scrie simptomele, un eveniment sau cere oresursa (ajutor) anume– ambulanta, pompierii, unitatea <strong>de</strong> <strong>de</strong>scarcerare saupolitia. Ambulantele trebuie dispecerizate numai dupa <strong>in</strong>terpretarea evenimentuluisau simptomelor <strong>de</strong>scrise <strong>de</strong> catre apelant. Acest proces poate filimitat cand apelantul nu este <strong>in</strong>susi pacientul sau nu se afla <strong>in</strong> apropiereapacientului. Daca se foloseste un protocol, <strong>in</strong>trebarile pot fi protocolizate,dar <strong>in</strong>terpretarea raspunsurilor nu; acesta este un pas necesar <strong>in</strong>a<strong>in</strong>tea puneriiurmatoarei <strong>in</strong>trebari. Acest element este frecvent ignorat <strong>in</strong> studiileasupra protocoalelor <strong>de</strong> dispecerizare (1).Faza II: prioritatea. Cand s-a stabilit necesitatea trimiterii unei ambulante<strong>in</strong> faza I, urmatoarea <strong>de</strong>cizie trebuie sa se refere la tipul <strong>de</strong> ambulanta sitipul <strong>de</strong> echipaj care trebuie alocat cazului respectiv. Aceasta <strong>de</strong>cizie va filuata <strong>in</strong> functie <strong>de</strong> simptomele pacientului sau tipul <strong>de</strong> eveniment.Faza III: actiunea. Faza <strong>de</strong> actiune presupune trimiterea unui echipaja<strong>de</strong>cvat tipului <strong>de</strong> <strong>urgenta</strong> si tipului <strong>de</strong> eveniment. Daca situatia este apre-Recomandări şi Protocoale în Anestezie, Terapie Intensivă şi Medic<strong>in</strong>ă <strong>de</strong> Urgenţă


ciata ca fi<strong>in</strong>d critica pentru viata pacientului, un al doilea dispecer va puteafi conectat la apel. Sarc<strong>in</strong>a celui <strong>de</strong>-al doilea dispecer este <strong>de</strong> a dispecerizasi directiona echipajul la caz <strong>in</strong> timp ce dispecerul care a primit apelul dasfaturi si <strong>in</strong>structiuni <strong>in</strong> functie <strong>de</strong> tipul urgentei, <strong>de</strong> exemplu <strong>in</strong>structiunile<strong>de</strong> resuscitare cardiorespiratorie pentru martorii unui stop cardiac. Pentrudispecerii d<strong>in</strong> serviciile <strong>de</strong> <strong>urgenta</strong> exista necesitatea educatiei cont<strong>in</strong>ue sirecertificarii (1).Recomandari:1. Dispeceratul 112 necesită tra<strong>in</strong><strong>in</strong>g cont<strong>in</strong>uu, protocoale naţionale şi unsistem <strong>de</strong> control al calităţii (Clasa I, Nivel C) (3).2. Dispeceratul 112 poate aviza pr<strong>in</strong> telefon auto-adm<strong>in</strong>istrarea <strong>de</strong> aspir<strong>in</strong>aoral (<strong>de</strong> mestecat) 150-325 mg <strong>in</strong> cazul <strong>in</strong> care nu exista alergie laaspir<strong>in</strong>a (Clasa IIa, Nivel C) <strong>in</strong>a<strong>in</strong>te <strong>de</strong> ajungerea echipajului <strong>de</strong> <strong>urgenta</strong><strong>in</strong> prespital (3) la pacientul cu durere toracica.597A patra poarta: Serviciile medicale <strong>de</strong> <strong>urgenta</strong> d<strong>in</strong> prespitalEvaluarea si tratamentul <strong>durerii</strong> <strong>toracice</strong> <strong>de</strong> catre serviciile medicale <strong>de</strong><strong>urgenta</strong> prespitalicesti poate fi facuta <strong>de</strong> catre diverse tipuri <strong>de</strong> echipaje <strong>in</strong>functie <strong>de</strong> calificare: <strong>de</strong> la echipaje <strong>de</strong> prim ajutor calificat, la echipajele cuasistent medical, medic sau echipaje <strong>de</strong> terapie <strong>in</strong>tensiva mobila.Pr<strong>in</strong>cipalele obiective ale asistentei medicale <strong>de</strong> <strong>urgenta</strong> <strong>in</strong> prespital <strong>in</strong>cazul pacientului cu durere toracica care apeleaza Dispeceratul 112 sunt:• sust<strong>in</strong>erea functiilor vitale• stabilizarea pacientului• <strong>in</strong>ceperea etapelor <strong>de</strong> diagnostic• <strong>in</strong>ceperea tratamentului simptomatic• prevenirea aparitiei complicatiilor si leziunilor ireversibile.Obiectivul echipajului medical d<strong>in</strong> prespital este <strong>de</strong> a <strong>de</strong>ci<strong>de</strong> daca pacientulare nevoie <strong>de</strong> tratament <strong>de</strong> <strong>urgenta</strong>, evi<strong>de</strong>nt <strong>in</strong> cazul pacientului <strong>in</strong>stabilsau necesitand anamneza si examen fizic complet. Decizia transportului <strong>de</strong><strong>urgenta</strong> la spital va fi luata si daca pacientul are istoric <strong>de</strong> boala ischemicacoronariana sau risc crescut pr<strong>in</strong> prezenta factorilor <strong>de</strong> risc: hiperlipi<strong>de</strong>mie,diabet, fumat, hipertensiune, sex mascul<strong>in</strong> si vârsta peste 50 <strong>de</strong> ani, sex fem<strong>in</strong><strong>in</strong>si vârsta peste 60 <strong>de</strong> ani, antece<strong>de</strong>nte heredocolaterale coronariene.Dar aceste <strong>in</strong>formatii sunt uneori dificil <strong>de</strong> obt<strong>in</strong>ut <strong>de</strong> catre echipajul d<strong>in</strong>prespital la fata locului sau <strong>in</strong> ambulanta.Timisoara 2009


598Recomandari pentru serviciile medicale <strong>de</strong> <strong>urgenta</strong> d<strong>in</strong> prespital:A. 1. Serviciile medicale <strong>de</strong> urgenţă d<strong>in</strong> prespital vor avea programe <strong>de</strong>formare si dotare pentru <strong>de</strong>fibrilare (Clasa I, Nivel A).2. In cazurile <strong>de</strong> stop cardiorespirator se va efectua resuscitare cardiopulmonarasi <strong>de</strong>fibrilare semiautomată - AED (Clasa I, Nivel B).B. Evaluarea şi tratamentul <strong>durerii</strong> <strong>toracice</strong> în prespital:1. Adm<strong>in</strong>istrare 150-325 mg aspir<strong>in</strong>ă (Clasa I, Nivel C).2. Efectuarea electrocardiogramei 12 <strong>de</strong>rivatii <strong>in</strong> prespital este un elementce faciliteaza precizarea diagnosticului si sca<strong>de</strong> timpul <strong>de</strong> <strong>abordare</strong>a pacientului la ajungerea la spital, <strong>in</strong> Unitatea Primire Urgente(Clasa IIa, Nivel B).Inregistrarea ECGAlaturi <strong>de</strong> istoric si semnele cl<strong>in</strong>ice, ECG este cel mai puternic <strong>in</strong>strument<strong>de</strong> diagnostic a ischemiei miocardice pâna la ajungerea <strong>in</strong> spital. FolosireaECG <strong>in</strong>a<strong>in</strong>tea ajungerii la spital a fost asociata cu sca<strong>de</strong>rea ratei mortalitatiila pacientii cu durere toracica acuta. Mai mult, s-a <strong>de</strong>monstrat o reducere atimpului <strong>de</strong> <strong>in</strong>tarziere <strong>in</strong> spital pana la efectuarea electrocardiogramei. I<strong>de</strong>al,ECG va fi realizat si <strong>in</strong>terpretat la fata locului la primul contact cu pacientul.In absenta unui sistem <strong>de</strong> <strong>in</strong>terpretare rapida, ECG va fi transmisa la spitalpentru <strong>in</strong>terpretarea <strong>de</strong> catre un medic. Aceasta trebuie realizata rapid si<strong>de</strong> calitate. Transferul rapid si <strong>de</strong> calitate trebuie sa fie posibil pr<strong>in</strong> l<strong>in</strong>iiletelefonice standard sau pr<strong>in</strong> retelele <strong>de</strong> comunicare <strong>in</strong>formatica pr<strong>in</strong> sistem<strong>de</strong> telemedic<strong>in</strong>a, <strong>in</strong> curs <strong>de</strong> implementare <strong>in</strong> Romania.Markerii biochimiciTeoretic o proba <strong>de</strong> sange poate fi utila <strong>in</strong> prespital pentru a <strong>de</strong>term<strong>in</strong>aprezenta necrozei miocardice si a sust<strong>in</strong>e diagnosticul pozitiv <strong>de</strong> <strong>in</strong>farct miocardicacut. Nu exista <strong>in</strong>ca studii care sa sust<strong>in</strong>a valoarea unei asemeneaproceduri <strong>in</strong> prespital. Datele prelim<strong>in</strong>are <strong>in</strong>dica faptul ca <strong>in</strong> zonele cu untimp redus <strong>de</strong> <strong>in</strong>terventie <strong>in</strong> prespital, un test rapid al tropon<strong>in</strong>elor facut lalocul <strong>in</strong>terventiei <strong>in</strong>a<strong>in</strong>te <strong>de</strong> <strong>in</strong>ternare a <strong>in</strong><strong>de</strong>ntificat un numar mic <strong>de</strong> pacienticu <strong>in</strong>farct miocardic acut (1).TratamentulElementele tratamentului <strong>in</strong> prespital pentru reducerea <strong>durerii</strong>, adm<strong>in</strong>istrareaaspir<strong>in</strong>ei, agentilor fibr<strong>in</strong>olitici, nitratilor, hepar<strong>in</strong>ei si betablocantelorsunt <strong>de</strong>scrise <strong>in</strong> ghidurile <strong>de</strong> management <strong>in</strong> prespital al <strong>in</strong>farctului miocardicacut (2, 4).Recomandări şi Protocoale în Anestezie, Terapie Intensivă şi Medic<strong>in</strong>ă <strong>de</strong> Urgenţă


Tromboliza <strong>in</strong> prespital (Clasa IIa, Nivel A)Pentru realizarea trombolizei <strong>in</strong> prespital atunci cand nu se ajunge la uncentru <strong>de</strong> cateterism pentru angioplastie <strong>in</strong> < 120 m<strong>in</strong> sau timpul pana laspital este > 30 m<strong>in</strong> se utilizeaza o lista <strong>de</strong> control -”checklist“ <strong>de</strong> reperfuziesi transmitere <strong>de</strong> date catre spital <strong>in</strong> ve<strong>de</strong>rea <strong>de</strong>ciziei <strong>de</strong> reperfuzie farmacologica.(Clasa IIa,Nivel C)TransportulPacientii trebuie transportati la spital. Ei pot fi transportati catre structurile<strong>de</strong> primire urgente (UPU/CPU) sau direct catre centrele <strong>de</strong> cardiologie cuposibilitati <strong>de</strong> angiografie si angioplastie coronariana percutana (PCI/PTCA).Ultimele alternative pot reduce <strong>in</strong>tervalul <strong>de</strong> <strong>in</strong>cepere a unui tratament <strong>in</strong>situatia cand viata pacientului e pusa <strong>in</strong> pericol. Acesta este important pentrupacientii cu risc ridicat cum sunt cei cu disfunctie severa a ventricululuistâng (soc, e<strong>de</strong>m pulmonar) (3).599A c<strong>in</strong>cea poarta: SpitalulScopurile pr<strong>in</strong>cipale <strong>in</strong> evaluarea si tratarea pacientilor <strong>in</strong> structurile <strong>de</strong>primire urgente sunt:• sust<strong>in</strong>erea functiilor vitale• stabilizarea pacientului• prevenirea <strong>de</strong>zvoltarii leziunilor ireversibile• stabilirea diagnosticului pozitiv si efectuarea diagnosticului diferential• <strong>in</strong>itierea tratamentului.Timpul petrecut <strong>de</strong> un pacient cu durere toracica <strong>in</strong>tr-un <strong>de</strong>partament <strong>de</strong><strong>urgenta</strong> variaza <strong>de</strong> la raspunsul imediat <strong>in</strong> cazurile <strong>de</strong> stop cardiac la <strong>de</strong>mersuridiagnostice si monitorizarea <strong>durerii</strong> <strong>toracice</strong> cu reevaluare <strong>in</strong> unitatea<strong>de</strong> primire urgente - pana la 24 <strong>de</strong> ore. Decizia pe care trebuie sa o ia echipad<strong>in</strong> <strong>de</strong>partamentul <strong>de</strong> <strong>urgenta</strong> este aceea <strong>de</strong> a <strong>in</strong>terna pacientul <strong>in</strong> terapie<strong>in</strong>tensiva coronarieni, terapie <strong>in</strong>tensiva generala, sectia <strong>de</strong> cardiologie, trimiterea<strong>de</strong> <strong>urgenta</strong> <strong>in</strong> laboratorul <strong>de</strong> cateterism cardiac, <strong>in</strong>ternarea <strong>in</strong> altasectie a spitalului sau ment<strong>in</strong>erea <strong>in</strong> <strong>de</strong>partamentul <strong>de</strong> <strong>urgenta</strong> cu monitorizareafunctiilor vitale si reevaluare cl<strong>in</strong>ica si paracl<strong>in</strong>ica (ECG, markeri cardiaci,Rx toracic) la <strong>in</strong>terval <strong>de</strong> 3-6 h <strong>in</strong> urma careia se va <strong>de</strong>ci<strong>de</strong> <strong>in</strong>ternareasau externarea <strong>in</strong> conditii <strong>de</strong> siguranta. In tot acest <strong>in</strong>terval se va efectuatratamentul etiologic <strong>in</strong> <strong>urgenta</strong> si tratamentul simptomatic daca au fostexcluse urgentele majore, care impun manevre <strong>de</strong> resuscitare.Propunem <strong>in</strong> cadrul acestui protocol 4 algoritmi <strong>in</strong> acord cu ghidurile <strong>de</strong>practica europene si americane, 4 algoritmi care urmaresc traseul pacientu-Timisoara 2009


sectie a spitalului sau ment<strong>in</strong>erea <strong>in</strong> <strong>de</strong>partamentul <strong>de</strong> <strong>urgenta</strong> cu monitorizavitale si reevaluare cl<strong>in</strong>ica si paracl<strong>in</strong>ica (ECG, markeri cardiaci, Rx toracic) la6 h <strong>in</strong> urma careia se va <strong>de</strong>ci<strong>de</strong> <strong>in</strong>ternarea sau externarea <strong>in</strong> conditii <strong>de</strong> sigacest <strong>in</strong>terval se va efectua tratamentul etiologic <strong>in</strong> <strong>urgenta</strong> si tratamentul simpau fost lui excluse cu durere urgentele toracica <strong>de</strong> majore, la apelul care catre impun serviciu manevre medical <strong>de</strong> pr<strong>in</strong> resuscitare. telefon sauprezentandu-se la un medic. Acesti algoritmi cupr<strong>in</strong>d mai multi pasi numerotatisi <strong>de</strong>scrisi <strong>in</strong> <strong>in</strong> cadrul cont<strong>in</strong>uare acestui si care protocol fac trimitere 4 algoritmi <strong>in</strong> anumite <strong>in</strong> etape acord la alte cu ghidurilePropunemeuropene protocoale si americane, existente, 4 aprobate algoritmi si traduse: care urmaresc Ghidul <strong>de</strong> Infarct traseul Miocardic pacientului Acut cu durerla apelul cu supra<strong>de</strong>nivelare catre un serviciu <strong>de</strong> segment medical ST (STEMI) pr<strong>in</strong> telefon (2, 4), Ghidul sau prezentandu-se pentru S<strong>in</strong>droame la un malgoritmi Coronariene cupr<strong>in</strong>d Acute mai multi fara supra<strong>de</strong>nivelare pasi numerotati ST (9), si <strong>de</strong>scrisi Ghidul <strong>de</strong> <strong>in</strong> Ang<strong>in</strong>a cont<strong>in</strong>uare pectorala si care faanumite etc. etape la alte protocoale existente, aprobate si traduse: Ghidul <strong>de</strong> InfaAcut cu supra<strong>de</strong>nivelare <strong>de</strong> segment ST (STEMI) (2, 4), Ghidul pentruFigura 1. Algoritm durere toracica I (6)Coronariene Acute fara supra<strong>de</strong>nivelare ST (9), Ghidul <strong>de</strong> Ang<strong>in</strong>a pectorala et600Contactul <strong>in</strong>itial cu pacientulcu durere toracica saudisconfort, personal sau pr<strong>in</strong>1apel telefonic2Evaluarea<strong>in</strong>itiala <strong>in</strong> triaj<strong>in</strong>dica riscridicat?NuDaEx. cl<strong>in</strong>ic- Aplicatialgoritmul <strong>de</strong>evaluare cl<strong>in</strong>ica3Scurta anamnezaefectuata <strong>de</strong>personalul medical45 Simptome<strong>de</strong> riscridicat lamomentulapelului6Simptome<strong>de</strong> riscridicat <strong>in</strong>ultimele 2zileSimptome<strong>de</strong> riscridicat <strong>in</strong><strong>in</strong>tervalul 3zile-2Simptome<strong>de</strong> riscridicat <strong>in</strong><strong>in</strong>tervalul 2saptamani-8 saptamani102 luniSimptome<strong>de</strong> riscridicat <strong>de</strong>peste 2 luni122Urgenta<strong>in</strong>certa14Transfer la<strong>de</strong>partamentul <strong>de</strong><strong>urgenta</strong>Evaluarecl<strong>in</strong>ica <strong>in</strong>aceeasi ziEvaluarecl<strong>in</strong>ica <strong>in</strong>72 <strong>de</strong> ore7 9 11Evaluarecl<strong>in</strong>icaelectiva <strong>in</strong>ultimele 2saptamani13Evaluarecl<strong>in</strong>ica <strong>in</strong>aceeasi zi1516Aplicati algoritmul<strong>de</strong> evaluare <strong>in</strong><strong>urgenta</strong>17Aplicati algoritmul<strong>de</strong> evaluare cl<strong>in</strong>icaFigura 1. Algoritm durere toracica I (6)1. Contactul <strong>in</strong>itial cu un pacient cu durere toracica sau disconfort care sspital sau apeleaza telefonic serviciile <strong>de</strong> <strong>urgenta</strong>Recomandări şi Protocoale în Anestezie, Terapie Intensivă şi Medic<strong>in</strong>ă <strong>de</strong> Urgenţă2. Evaluarea <strong>in</strong>itiala pr<strong>in</strong> protocolul <strong>de</strong> triaj <strong>in</strong>dica un risc ridicat pentru pa3. Evaluare cl<strong>in</strong>ica obisnuita cu programare4. Scurt istoric efectuat <strong>de</strong> personalul medical5. Simptome <strong>de</strong> risc <strong>in</strong>alt la momentul apelului


1. Contactul <strong>in</strong>itial cu un pacient cu durere toracica sau disconfort care seprez<strong>in</strong>ta la spital sau apeleaza telefonic serviciile <strong>de</strong> <strong>urgenta</strong>2. Evaluarea <strong>in</strong>itiala pr<strong>in</strong> protocolul <strong>de</strong> triaj <strong>in</strong>dica un risc ridicat pentrupacient?3. Evaluare cl<strong>in</strong>ica obisnuita cu programare4. Scurt istoric efectuat <strong>de</strong> personalul medical5. Simptome <strong>de</strong> risc <strong>in</strong>alt la momentul apelului6. Simptome <strong>de</strong> risc <strong>in</strong>alt <strong>in</strong> ultimele doua zile7. Transport medicalizat <strong>de</strong> <strong>urgenta</strong> <strong>in</strong> Unitatea Primire Urgente8. Simptome <strong>de</strong> risc <strong>in</strong>alt <strong>in</strong> ultimele doua saptamani pana la 3 zile9. Evaluare cl<strong>in</strong>ica <strong>in</strong> aceeasi zi10. Simptome <strong>de</strong> risc <strong>in</strong>alt <strong>in</strong> <strong>in</strong>tervalul <strong>de</strong> la 3 saptamani la 2 luni11. Evaluare cl<strong>in</strong>ica <strong>in</strong> urmatoarele 72 ore12. Simptome <strong>de</strong> risc <strong>in</strong>alt aparute <strong>in</strong> urma cu mai mult <strong>de</strong> doua luni13. Evaluare cl<strong>in</strong>ica cu programare <strong>in</strong> urmatoarele doua saptamani14. Grad <strong>de</strong> <strong>urgenta</strong> ne<strong>de</strong>term<strong>in</strong>at pr<strong>in</strong> triaj sau discutia la telefon15. Pacientul va fi evaluat cl<strong>in</strong>ic <strong>in</strong> aceeasi zi <strong>in</strong> ambulatoriu sau <strong>in</strong> <strong>urgenta</strong>16. Pacientul va fi evaluat conform protocolului <strong>de</strong> <strong>urgenta</strong>17. Pacientul va fi evaluat conform cu protocolul obisnuit <strong>de</strong> evaluarecl<strong>in</strong>ica60118. Durere toracica importanta cu semne <strong>de</strong> gravitate - <strong>in</strong>dica apelareaserviciilor <strong>de</strong> <strong>urgenta</strong> pr<strong>in</strong> Dispeceratul 112.19. Transport cu ambulanta <strong>in</strong> Unitatea Primire Urgente sau alte structuri<strong>de</strong> primire urgente (compartiment primire urgente - CPU, camera <strong>de</strong> garda)20. Evaluare <strong>in</strong> <strong>urgenta</strong> cu monitorizare cardiaca si <strong>in</strong>itierea primelor masuriterapeutice. La ajungerea <strong>in</strong> UPU/CPU pacientul ce acuza durere toracicava primi oxigen pe canula nazala sau masca 2-4 l/m<strong>in</strong> (Clasa 1, Nivel C),aspir<strong>in</strong>a p.o (<strong>de</strong> mestecat) - o doza <strong>in</strong>tre 150-325 mg (daca nu a fost <strong>de</strong>jaadm<strong>in</strong>istrata <strong>de</strong> catre echipajul <strong>de</strong> pe ambulanta) (2). Va fi efectuata electrocardiograma12 <strong>de</strong>rivatii <strong>in</strong>tr-un <strong>in</strong>terval <strong>de</strong> 10 m<strong>in</strong> <strong>de</strong> la primul contactmedical (Clasa I, Nivel C) si pacientul va fi conectat la monitor. Va fi apelatimediat medicul <strong>de</strong> <strong>urgenta</strong>. Se va obt<strong>in</strong>e acces <strong>in</strong>travenos si se va recoltasange pentru laborator, <strong>in</strong> primul rand pentru <strong>de</strong>term<strong>in</strong>area markerilorcardiaci - enzimele <strong>de</strong> necroza miocardica: tropon<strong>in</strong>a T, I, mioglob<strong>in</strong>a, CK,CK-MB.Tropon<strong>in</strong>a I si T au fost dovedite a avea o mare specificitate si sensibilitatepentru diagnosticul necrozei miocardice si ca element <strong>de</strong> predictie petermen scurt al riscului <strong>de</strong> <strong>in</strong>farct miocardic acut si <strong>de</strong>ces (9). RezultateleTimisoara 2009


Figura 2. Algoritm durere toracica II (6,9)18Durere toracicimportantApel 112602Transport cu ambulanaUPU/CPU19Evaluare imediat* Oxigen* Aspir<strong>in</strong> 150-325 mg* ECG – în 10 m<strong>in</strong>* Medic – în 15 m<strong>in</strong>* L<strong>in</strong>ie i.v.* Rx toracic20* Markeri cardiaci21Semne vitaleDaafectateNu23Simptomesugestive pt.SCADaNu40Durere nonSCA41NuDureretoracic importantaischemicaDavezi Algoritmispecifici AP43vezi Algoritm<strong>in</strong>oncardiaci4222ALS24Supra<strong>de</strong>nivelareSTDaNuDaTropon<strong>in</strong>aNu29pozitivaTerapie <strong>de</strong> reperfuzie(PCI/tromboliz)* Hepar<strong>in</strong>/HGMM* NTGvezi Algoritm STEMI* Beta-blocante26* Clopidogrel* Inhibitori IIb/IIIa25* Consult cardiologic27Modificari ST/TDa3030 Risc Crescut34 Risc <strong>in</strong>termediar38NSTEMI* Hepar<strong>in</strong>/HGMMAng<strong>in</strong>a <strong>in</strong>stabila* NTG * Beta-blocante* Internare* Clopidogrel* Terapie ne<strong>in</strong>vaziva* Inhibitori IIb/IIIa31 * Consult cardiologic35 3932InternareMonitorizare UPU36Markeri cardiaci 6 h33Cateterism 24-48 h37DaPacientul are pozitiv?Nu-markeri cardiaci-modificri ecg-tulburri <strong>de</strong> ritm-test <strong>de</strong> stressNu28ECG normal/echivocDaTropon<strong>in</strong>a29pozitivaNuRisc SczutExternare curecomandriFigura 2. Algoritm durere toracica II (6,9)trebuie sa fie disponibile <strong>in</strong> 60 m<strong>in</strong> (Clasa I, nivel C) (9). Determ<strong>in</strong>area BNP18. Durere toracica importanta cu semne <strong>de</strong> gravitate - <strong>in</strong>dica apelarea serviciilor <strong>de</strong>sau proBNP este utila pentru evaluarea functiei cardiace si riscului <strong>de</strong> <strong>de</strong>ces<strong>urgenta</strong> pr<strong>in</strong> Dispeceratul 112.la 19. pacientii Transport cu cu diagnostic ambulanta pozitiv <strong>in</strong> Unitatea <strong>de</strong> s<strong>in</strong>drom Primire Urgente coronarian sau alte acut. structuri <strong>de</strong> primireurgente Medicul (compartiment <strong>de</strong> garda primire <strong>in</strong> urgente UPU va - evalua CPU, camera functiile <strong>de</strong> garda) vitale, anamneza, examenulcl<strong>in</strong>ic 20. Evaluare si da <strong>in</strong> primele <strong>urgenta</strong> <strong>in</strong>dicatii cu monitorizare terapeutice: cardiaca pe langa si <strong>in</strong>itierea oxigen si primelor aspir<strong>in</strong>a, masuri vaterapeutice. La ajungerea <strong>in</strong> UPU/CPU pacientul ce acuza durere toracica va primi oxigenpe canula <strong>de</strong>ci<strong>de</strong> nazala daca sau trebuie masca adm<strong>in</strong>istrata 2-4 l/m<strong>in</strong> (Clasa nitroglicer<strong>in</strong>a 1, Nivel C), subl<strong>in</strong>gual aspir<strong>in</strong>a p.o sau (<strong>de</strong> i.v. mestecat) (Clasa I, - odoza Nivel <strong>in</strong>tre C) 150-325 si morf<strong>in</strong>a mg 4-8 (daca mg, nu care a fost poate <strong>de</strong>ja fi adm<strong>in</strong>istrata repetata (Clasa <strong>de</strong> catre 1, Nivel echipajul C) sau <strong>de</strong> alt peambulanta) analgetic (2). Va major fi efectuata pentru electrocardiograma tratamentul <strong>durerii</strong> 12 (2, <strong>de</strong>rivatii 4). <strong>in</strong>tr-un <strong>in</strong>terval <strong>de</strong> 10 m<strong>in</strong> <strong>de</strong>la primul contact medical (Clasa I, Nivel C) si pacientul va fi conectat la monitor. Va fi apelatRecomandări şi Protocoale în Anestezie, Terapie Intensivă şi Medic<strong>in</strong>ă <strong>de</strong> Urgenţă10


imediat medicul <strong>de</strong> <strong>urgenta</strong>. Se va obt<strong>in</strong>e acces <strong>in</strong>travenos si se va recolta sange pentrulaborator, <strong>in</strong> primul rand pentru <strong>de</strong>term<strong>in</strong>area markerilor cardiaci - enzimele <strong>de</strong> necrozamiocardica: 21. Semne tropon<strong>in</strong>a vitale afectate? T, I, mioglob<strong>in</strong>a, CK, CK-MB.Daca Tropon<strong>in</strong>a pacientul I si are T au semne fost dovedite vitale afectate: a avea o mare stop specificitate cardio-respirator, si sensibilitate tahiaritmiimiocardic si bradicardii acut si severe, <strong>de</strong>ces soc (9). Rezultatele sau hipotensiune trebuie sa va fie fi disponibile tratat conform <strong>in</strong> 60 m<strong>in</strong> pro-(Clasa I,pentrudiagnosticul necrozei miocardice si ca element <strong>de</strong> predictie pe termen scurt al riscului <strong>de</strong><strong>in</strong>farctnivel tocoalelor C) (9). Determ<strong>in</strong>area <strong>de</strong> resuscitare BNP ale sau Consiliului proBNP este European utila pentru <strong>de</strong> Resuscitare evaluarea functiei 2005 cardiace (5) siriscului adoptate <strong>de</strong> <strong>de</strong>ces si catre la pacientii Consiliul cu diagnostic National pozitiv Roman <strong>de</strong> <strong>de</strong> s<strong>in</strong>drom Resuscitare coronarian (7). acut.Medicul <strong>de</strong> garda <strong>in</strong> UPU va evalua functiile vitale, anamneza, examenul cl<strong>in</strong>ic si va da22. Aplicarea Protocoalelor <strong>de</strong> resuscitare cardio-pulmonara (5, 7, 8)primele <strong>in</strong>dicatii terapeutice: pe langa oxigen si aspir<strong>in</strong>a, va <strong>de</strong>ci<strong>de</strong> daca trebuieadm<strong>in</strong>istrata 23. Simptomele nitroglicer<strong>in</strong>a sugereaza subl<strong>in</strong>gual posibilitatea sau i.v. (Clasa unui I, S<strong>in</strong>drom Nivel C) Coronarian si morf<strong>in</strong>a 4-8 Acut mg, carepoate (SCA)? fi repetata (Clasa 1, Nivel C) sau alt analgetic major pentru tratamentul <strong>durerii</strong> (2, 4).- Durerea 21. Semne toracica vitale are afectate? caracterele <strong>durerii</strong> ischemice: presiune sau greutateDaca pacientul are semne vitale afectate: stop cardio-respirator, tahiaritmii si bradicardiisevere, retrosternala soc sau care hipotensiune iradiaza va <strong>in</strong> fi bratul tratat conform stang, protocoalelor gat sau mandibula? <strong>de</strong> resuscitare Atentie ale Consiliului laEuropean prezentarile <strong>de</strong> atipice! Resuscitare 2005 (5) adoptate si <strong>de</strong> catre Consiliul National Roman <strong>de</strong>Resuscitare - Exista un (7). diagnostic anterior <strong>de</strong> boala cardiaca ischemica?60322. Aplicarea Protocoalelor <strong>de</strong> resuscitare cardio-pulmonara (5, 7, 8)- Sunt 23. Simptomele prezenti factori sugereaza <strong>de</strong> risc posibilitatea cardiaci? unui S<strong>in</strong>drom Coronarian Acut (SCA)?- Durerea 24. Aspect toracica electrocardiografic are caracterele <strong>durerii</strong> <strong>de</strong> Infarct ischemice: Miocardic presiune Acut sau cu greutate supra<strong>de</strong>nivelareiradiaza <strong>de</strong> segment <strong>in</strong> bratul ST stang, gat sau mandibula? Atentie la prezentarile atipice!retrosternalacare- Exista un diagnostic anterior boala cardiaca ischemica?Electrocardiograma 12 <strong>de</strong>rivatii sau 18 <strong>de</strong>rivatii va fi obt<strong>in</strong>uta imediat- Sunt prezenti factori <strong>de</strong> risc cardiaci?la ajungerea 24. Aspect pacientului electrocardiografic <strong>in</strong> UPU - <strong>de</strong> timp Infarct maxim Miocardic recomandat Acut cu 10 supra<strong>de</strong>nivelare m<strong>in</strong> (1,2). <strong>de</strong>segment Aparitia ST unei supra<strong>de</strong>nivelari a segmentului ST mai mare <strong>de</strong> 1 mm <strong>in</strong> maiElectrocardiograma mult <strong>de</strong> doua <strong>de</strong>rivatii 12 <strong>de</strong>rivatii ale membrelor sau 18 <strong>de</strong>rivatii sau mai va mare fi obt<strong>in</strong>uta <strong>de</strong> 2 mm imediat <strong>in</strong> cel la put<strong>in</strong> ajungereapacientului <strong>in</strong> UPU - timp maxim recomandat 10 m<strong>in</strong> (1,2). Aparitia unei supra<strong>de</strong>nivelari asegmentului doua <strong>de</strong>rivatii ST precordiale, mai mare <strong>de</strong> precum 1 mm <strong>in</strong> si mai aparitia mult <strong>de</strong> unui doua bloc <strong>de</strong>rivatii <strong>de</strong> ram ale stang membrelor (BRS) la sau maimare un pacient <strong>de</strong> 2 mm cu <strong>in</strong> durere cel put<strong>in</strong> toracica doua <strong>de</strong>rivatii semneaza precordiale, diagnosticul precum pozitiv si aparitia al unui unui <strong>in</strong>farct bloc <strong>de</strong> ramstang miocardic (BRS) acut. la un pacient cu durere toracica semneaza diagnosticul pozitiv al unui <strong>in</strong>farctmiocardic acut.Tabel nr. 2. Manifestari electrocardiografice <strong>in</strong> ischemia miocardica acuta (dupa 2).Tabel nr. 2. Manifestari electrocardiografice <strong>in</strong> ischemia miocardica acuta (dupa 2).25. Tratamentul IMA la <strong>de</strong>but cupr<strong>in</strong><strong>de</strong> <strong>in</strong>ca d<strong>in</strong> Unitatea Primire Urgente: aspir<strong>in</strong>a,hepar<strong>in</strong>a/hepar<strong>in</strong>e 25. Tratamentul cu IMA greutate la <strong>de</strong>but moleculara cupr<strong>in</strong><strong>de</strong> mica <strong>in</strong>ca - d<strong>in</strong> enoxapar<strong>in</strong>a, Unitatea Primire nitrati, Urgente:aspir<strong>in</strong>a, <strong>in</strong>hibitori hepar<strong>in</strong>a/hepar<strong>in</strong>e <strong>de</strong> receptori cu IIb/IIIa, greutate terapia moleculara <strong>de</strong> reperfuzie mica - enoxapar<strong>in</strong>a,farmacologica saubeta-blocante,clopidogrel,orientarea spre angioplastie percutana (Clasa I, Nivel A), consult cardiologic.nitrati, beta-blocante, clopidogrel, <strong>in</strong>hibitori <strong>de</strong> receptori IIb/IIIa, terapia <strong>de</strong>26. Tratamentul IMA cu supra<strong>de</strong>nivelare <strong>de</strong> ST se va efectua conform protocoluluiSocietatii reperfuzie Europene farmacologica <strong>de</strong> Cardiologie sau orientarea pentru Infarctul spre angioplastie Miocardic Acut percutana Supra<strong>de</strong>nivelare (Clasa <strong>de</strong>ST I, Nivel (2) preluat A), consult si <strong>in</strong> cardiologic.cadrul Ghidului <strong>de</strong> diagnostic si tratament <strong>in</strong> faza <strong>de</strong> prespital al26. Tratamentul IMA cu supra<strong>de</strong>nivelare <strong>de</strong> ST se va efectua conform protocoluluiSocietatii Europene <strong>de</strong> Cardiologie pentru Infarctul Miocardic Acutcu Supra<strong>de</strong>nivelare <strong>de</strong> ST (2) preluat si <strong>in</strong> cadrul Ghidului <strong>de</strong> diagnostic si 11Timisoara 2009


604tratament <strong>in</strong> faza <strong>de</strong> prespital al <strong>in</strong>farctului miocardic acut cu supra<strong>de</strong>nivelare<strong>de</strong> segment ST - ghid creat pr<strong>in</strong> consensul a sase societati medicale d<strong>in</strong>Romania (4).27. Daca pacientul cu durere toracica are modificari electrocardiograficeale segmentului ST si un<strong>de</strong>i T, altele <strong>de</strong>cat supra<strong>de</strong>nivelarea segmentului ST<strong>de</strong>cizia medicului <strong>de</strong> <strong>urgenta</strong> va fi luata <strong>in</strong> functie <strong>de</strong> valoarea enzimelorcardiace, <strong>in</strong> primul rand al tropon<strong>in</strong>ei I sau T.28.29. Tropon<strong>in</strong>ele sunt cei mai buni markeri biochimici pentru apreciereaprognosticului pe termen scurt (la 30 zile) în ceea ce priveste riscul <strong>de</strong> <strong>in</strong>farctmiocardic si <strong>de</strong>ces. Cresterea riscului asociata cu niveluri crescute aletropon<strong>in</strong>elor este <strong>in</strong><strong>de</strong>pen<strong>de</strong>nta si aditiva celorlalti factori <strong>de</strong> risc precummodificările ECG <strong>in</strong> repaus sau la monitorizarea cont<strong>in</strong>ua sau markeri aiactivitatii <strong>in</strong>flamatorii. In plus, i<strong>de</strong>ntificarea pacientilor cu niveluri crescuteal tropon<strong>in</strong>elor este <strong>de</strong> asemenea utila pentru selectia terapiei a<strong>de</strong>cvate lapacientii cu s<strong>in</strong>droame coronariene acute fara supra<strong>de</strong>nivelare <strong>de</strong> segmentST (9). Un s<strong>in</strong>gur test negativ al tropon<strong>in</strong>ei <strong>in</strong> momentul prezentarii la spitaleste <strong>in</strong>suficient pentru a exclu<strong>de</strong> o crestere ulterioara, <strong>in</strong> conditiile <strong>in</strong> carela cei mai multi pacienti cresterea poate fi <strong>de</strong>tectata <strong>in</strong> orele care urmeaza.Astfel, sunt necesare probe sangv<strong>in</strong>e si masuratori repetate 6-12 ore <strong>de</strong> la<strong>in</strong>ternare si dupa episoa<strong>de</strong>le ang<strong>in</strong>oase severe, cu scopul <strong>de</strong> a <strong>de</strong>monstra saua exclu<strong>de</strong> lezarea miocardica. O a doua <strong>de</strong>term<strong>in</strong>are poate fi necesara doar<strong>in</strong> cazul <strong>in</strong> care ultimul episod ang<strong>in</strong>os a fost prezent la mai mult <strong>de</strong> 12 oreanterior <strong>de</strong>term<strong>in</strong>arii <strong>in</strong>itiale a tropon<strong>in</strong>elor. Este important <strong>de</strong> subl<strong>in</strong>iat casi alte conditii patologice amen<strong>in</strong>tatoare <strong>de</strong> viata, care se prez<strong>in</strong>ta cl<strong>in</strong>ic cudurere toracica, precum disectia anevrismelor aortice sau embolismul pulmonarpot <strong>de</strong>term<strong>in</strong>a cresterea nivelului tropon<strong>in</strong>elor si trebuie <strong>in</strong>tot<strong>de</strong>aunaavute <strong>in</strong> ve<strong>de</strong>re ca diagnostice diferentiale. Cresteri ale tropon<strong>in</strong>elor cardiaceapar <strong>de</strong> asemenea <strong>in</strong> cadrul leziunilor miocardice non-coronariene (tabelnr. 3).Evaluarea riscului <strong>de</strong> catre echipa medicala d<strong>in</strong> <strong>urgenta</strong> are rolul <strong>de</strong> a impartipacientii cu durere <strong>toracice</strong> <strong>de</strong> tip ischemic, fara supra<strong>de</strong>nivelare <strong>de</strong> ST<strong>in</strong> trei grupe: risc crescut, risc <strong>in</strong>termediar si risc scazut.Urmatorii predictori ai <strong>de</strong>cesului pe termen lung sau a aparitiei <strong>in</strong>farctuluimiocardic trebuie luati <strong>in</strong> consi<strong>de</strong>rare <strong>in</strong> stratificarea riscului (Clasa I,Nivel B) (9):- <strong>in</strong>dicatori cl<strong>in</strong>ici: varsta, frecventa cardiaca, tensiunea arteriala, clasaKillip, diabet, boala cardiaca ischemica sau <strong>in</strong>farct miocardic <strong>in</strong> antece<strong>de</strong>nte;- markeri ECG: sub<strong>de</strong>nivelare <strong>de</strong> segment ST;- markeri <strong>de</strong> laborator: tropon<strong>in</strong>e, BNP/NT-proBNP, hsCRP;Recomandări şi Protocoale în Anestezie, Terapie Intensivă şi Medic<strong>in</strong>ă <strong>de</strong> Urgenţă


Tabel 3. Cauze noncoronariene <strong>de</strong> crestere a tropon<strong>in</strong>elor (9).Insuficienta cardiaca severa: acuta sau cronicaDisecţia <strong>de</strong> aorta, valvulopatiile aortice, cardiomiopatia hipertroficaContuzia cardiaca, ablaţia, pac<strong>in</strong>gul, cardioversia sau biopsia endomiocardicaBolile <strong>in</strong>flamatorii, <strong>de</strong> exemplu miocardita sau afectarea miocardica <strong>in</strong> cadrul endocarditei/pericarditeiCriza hipertensivaTahi- sau bradi- aritmiileEmbolia pulmonara, hipertensiunea pulmonara severaHipotiroidismulS<strong>in</strong>dromul <strong>de</strong> “balonizare apicala”Disfunctia renala acuta sau cronicaBoli neurologice acute, <strong>in</strong>clusiv acci<strong>de</strong>ntul vascular sau hemoragia subarahnoidianaBoli imfiltrative: ex. amiloidoza, hemocromatoza, sarcoidoza, sclero<strong>de</strong>rmiaMedicamente cardiotoxice(ex. adriamic<strong>in</strong>a 5-fluorouracilul), hercept<strong>in</strong>e, ven<strong>in</strong> <strong>de</strong> sarpeArsurile afectand > 30 % d<strong>in</strong> suprafata corporalaRabdomiolizaPacientii <strong>in</strong> stare grava, <strong>in</strong> mod particular pacientii cu <strong>de</strong>tresa respiratorie sau sepsis605• dovezi imagistice: fractie <strong>de</strong> ejectie a ventriculului stang <strong>de</strong>term<strong>in</strong>ataecocardiografic redusa, leziune <strong>de</strong> trunchi al arterelor coronare, boala trivasculara.30. Risc crescut - pacienti ce vor fi <strong>in</strong>ternati <strong>in</strong> sectia <strong>de</strong> cardiologie, dupa<strong>in</strong>itierea masurilor <strong>de</strong> tratament <strong>de</strong> <strong>urgenta</strong>.31. Pacientii cu risc crescut vor fi monitorizati si vor primi <strong>in</strong>ca d<strong>in</strong> UnitateaPrimire Urgente tratament conform recomandarilor d<strong>in</strong> ghidul pentruS<strong>in</strong>droame Coronariene Acute fara supra<strong>de</strong>nivelare <strong>de</strong> segment ST. Tratamentulpentru pacientii cu risc crescut va <strong>in</strong>clu<strong>de</strong>: hepar<strong>in</strong>a nefractionatasau hepar<strong>in</strong>e cu greutate moleculara mica, nitrati, beta-blocante, clopridogel,<strong>in</strong>hibitori <strong>de</strong> receptori IIb/IIIa.32. Internare ca Infarct Miocardic Acut fara supra<strong>de</strong>nivelare <strong>de</strong> ST.33. Pacientul va fi <strong>in</strong>ternat sau transferat pentru realizarea cateterismuluicardiac <strong>in</strong> urmatoarele 24-48 ore.O strategie <strong>in</strong>vaziva precoce este benefica pentru majoritatea pacientilorcu <strong>in</strong>farct miocardic fara supra<strong>de</strong>nivelare <strong>de</strong> segment si s<strong>in</strong>drom coronaracut, <strong>in</strong> special cand aceasta este cuplata cu terapia adjuvanta <strong>de</strong> <strong>urgenta</strong>mentionata mai sus. Anumiti agenti anticoalgulanti sau antiplachetari agresivipot fi folositi cand simptomele sunt recurente si nu exista posibilitatea<strong>de</strong> efectuare a unei angiografii rapi<strong>de</strong>, ca <strong>in</strong> situatia <strong>in</strong>tarzierilor datoratevremii nefavorabile transportului sau cand nu e disponibil un laborator <strong>de</strong>Timisoara 2009


cateterism. Oricum, pentru pacientii care <strong>de</strong>v<strong>in</strong> <strong>in</strong>stabili sau au simptomerecurente <strong>in</strong> primul rand trebuie redus <strong>in</strong>tervalul <strong>de</strong> efectuare a angiografieisi revascularizarii coronariene percutanate.Tabel 4. Tratamentul precoce <strong>in</strong> SCA fara supra<strong>de</strong>nivelare ST (9)606Nitrati: Subl<strong>in</strong>gual sau <strong>in</strong>travenos (atentie daca TA sistolica < 90 mmHg)Clopidogrel: Doza <strong>de</strong> <strong>in</strong>carcare 300 mg (sau 600 mg pentru <strong>in</strong>stalare rapida a actiunii)Anticoagulante: Diferite optiuni <strong>de</strong>pen<strong>de</strong>nte <strong>de</strong> strategie:• Hepar<strong>in</strong>a nefractionata- HNF bolus <strong>in</strong>travenos 60-70 IU/kg (maxim 5000 IU) urmata <strong>de</strong><strong>in</strong>fuzie 12-15 IU/kg/h (maxim 1000 IU/h) titrare <strong>in</strong> functie <strong>de</strong> aPTT 1.5-2.5• Fondapar<strong>in</strong>ux 2.5 mg/zi subcutanat• Enoxapar<strong>in</strong>a 1 mg/kg <strong>de</strong> 2 ori/zi subcutanat• Daltepar<strong>in</strong>a 120 IU/kg <strong>de</strong> 2 ori/zisubcutanat• Nadropar<strong>in</strong> 86 IU/kg <strong>de</strong> 2 ori/zi subcutanat• Bivalirud<strong>in</strong> 0.1 mg/kg bolus urmata <strong>de</strong> 0.25 mg/kg/hBeta-blocante p.o sau i.v daca exista tahicardie sau hipertensiune fara semne <strong>de</strong> <strong>in</strong>suficientacardiacaInhibitori GP IIb/IIIa:• Abciximab bolus i.v 0,25 mg/kg, urmat <strong>de</strong> perfuzie iv 0,125 μg/kg/m<strong>in</strong> (maxim 10 μg/m<strong>in</strong>) pentru 12-24 ore• Eptifibatida 180 μg/kg bolus i.v (al doilea bolus dupa 10 m<strong>in</strong> <strong>in</strong> caz <strong>de</strong> PCI), urmat <strong>de</strong>perfuzie 2μg/kg/m<strong>in</strong> pentru 72-96 ore• Tirofiban 0,4 μg/kg/m<strong>in</strong> i.v în 30 m<strong>in</strong>, urmat <strong>de</strong> perfuzie 0,10 μg/kg/m<strong>in</strong> pentru 48-96ore.34. Risc <strong>in</strong>termediarAcest tip <strong>de</strong> risc nu este prezent <strong>in</strong> ghidul <strong>de</strong> SCA fara supra<strong>de</strong>nivelare <strong>de</strong>ST, dar pentru prezentarea <strong>in</strong> <strong>urgenta</strong> reprez<strong>in</strong>ta o categorie ce trebuie luat<strong>in</strong> seama. Un pacient cu risc <strong>in</strong>termediar <strong>de</strong> ang<strong>in</strong>a <strong>in</strong>stabila este <strong>de</strong> <strong>de</strong>partecea mai comuna prezentare <strong>in</strong> Unitatile <strong>de</strong> Primire Urgente. Aproximativ 50% d<strong>in</strong> acesti pacienti vor avea <strong>in</strong> f<strong>in</strong>al un diagnostic altul <strong>de</strong>cat s<strong>in</strong>dromulcoronar acut.35. In cazul diagnosticului <strong>de</strong> Ang<strong>in</strong>a Instabila riscul <strong>de</strong> <strong>de</strong>ces este un riscscazut (9), dar pacientul va fi <strong>in</strong>ternat <strong>in</strong> sectia <strong>de</strong> cardiologie si se va <strong>in</strong>itiatratamentul <strong>in</strong>ca d<strong>in</strong> <strong>de</strong>partamentul <strong>de</strong> <strong>urgenta</strong>, avand <strong>in</strong> ve<strong>de</strong>re strategiane<strong>in</strong>vaziva.36.37. Pacientii cu modificari electrocardiografice echivoce si tropon<strong>in</strong>anegativa vor fi ment<strong>in</strong>uti sub observatie <strong>in</strong> <strong>de</strong>partamentul <strong>de</strong> <strong>urgenta</strong> cumonitorizare cl<strong>in</strong>ica si paracl<strong>in</strong>ica; se repeta electrocardiograma si enzimelemiocardice, se vor efectua explorari imagistice si eventual test <strong>de</strong> stres/efort<strong>in</strong> <strong>urgenta</strong>. Daca acestea vor fi pozitive se va lua <strong>de</strong>cizia <strong>de</strong> <strong>in</strong>ternare aRecomandări şi Protocoale în Anestezie, Terapie Intensivă şi Medic<strong>in</strong>ă <strong>de</strong> Urgenţă


pacientului <strong>in</strong> sectia <strong>de</strong> cardiologie, daca vor ramane negative la evaluarirepetate pacientul va fi trecut <strong>in</strong> clasa <strong>de</strong> risc scazut.38.39. Risc scazut - pacienti fara modificari ECG sau cu modificari echivoce,cu valori negative ale tropon<strong>in</strong>elor la cel put<strong>in</strong> doua <strong>de</strong>term<strong>in</strong>ari pot fiexternati <strong>in</strong> siguranta d<strong>in</strong> <strong>de</strong>partamentul <strong>de</strong> <strong>urgenta</strong>.40. Durere toracica fara caracterele <strong>durerii</strong> d<strong>in</strong> s<strong>in</strong>droamele coronarieneacute (SCA), <strong>de</strong>ci o durere care nu se <strong>in</strong>cadreaza <strong>in</strong> nici una d<strong>in</strong> urmatoareleprezentari (9):- durere prelungita <strong>de</strong> repaus > 20 m<strong>in</strong>- ang<strong>in</strong>a severa nou <strong>in</strong>stalata (ang<strong>in</strong>a <strong>de</strong> novo)- ang<strong>in</strong>a crescendo (recent agravata)- ang<strong>in</strong>a post<strong>in</strong>farct miocardic41. Durere importanta <strong>de</strong> tip ischemic: presiunea sau greutatea retrostenala,care nu <strong>in</strong><strong>de</strong>pl<strong>in</strong>este criteriile cl<strong>in</strong>ice si paracl<strong>in</strong>ice ale s<strong>in</strong>droamelorcoronariene acute.42. Durere importanta dar care nu are caracterul <strong>durerii</strong> <strong>de</strong> tip ischemic:orienteaza diagnosticul spre alte cauze importante extra-cardiace – se cont<strong>in</strong>uacu algoritmul <strong>de</strong> durere toracica importanta non-ischemica - 44.43. Daca se i<strong>de</strong>ntifica o durere toracica <strong>de</strong> tip ischemic caracteristica pentruang<strong>in</strong>a pectorala (AP) - se vor urma pasii <strong>in</strong>dicati <strong>in</strong> ghidul <strong>de</strong> Ang<strong>in</strong>aPectorala Stabila (10).44. In cazul pacientilor cu durere toracica importanta dar non-ischemicase vor lua <strong>in</strong> consi<strong>de</strong>rare alte afectiuni severe: disectia <strong>de</strong> aorta, emboliapulmonara, pericardita, pneumotoraxul spontan sau afectiuni osteo-musculo-articulare,pleuro-pulmonare, gastro-<strong>in</strong>test<strong>in</strong>ale.60745. Investigatiile cl<strong>in</strong>ice sugereaza anevrism disecant <strong>de</strong> aorta sau anevrismsimptomatic- semne cl<strong>in</strong>ice ale ischemiei afecteaza mai multe organe si sisteme (potapare <strong>de</strong>ficite neurologice, pareza ischemica, etc); durerea toracica d<strong>in</strong>disectia <strong>de</strong> aorta este <strong>de</strong> obicei o durere brusc <strong>in</strong>stalatã, cu maximum<strong>de</strong> <strong>in</strong>tensitate la <strong>de</strong>but (12). Durerea este <strong>de</strong>scrisã mai frecvent ca fi<strong>in</strong>d“ascutita” <strong>de</strong>cat sfasietoare, este o durere „<strong>in</strong>grozitoare” sau comparatacu o „lovitura <strong>de</strong> pumnal”. In disectiile proximale durerea este localizata<strong>de</strong> obicei retrosternal, pe cand disectiile distale sunt caracterizate pr<strong>in</strong>durere <strong>in</strong>terscapulara sau dorsala.- durerea poate iradia d<strong>in</strong> torace la nivel lombar si <strong>in</strong> membrele <strong>in</strong>ferioare- semnele obisnuite ce <strong>in</strong>sotesc durerea toracica sunt: hipertensiune, sufluricardiace, zgomote sistolice, puls absent sau dim<strong>in</strong>uat la unul d<strong>in</strong>membrele superioare. Hipertensiunea este asociata tipic cu disectia dis-Timisoara 2009


tala. Deficitul <strong>de</strong> puls apare la aproximativ 50 % d<strong>in</strong>tre pacientii cuvarsta peste 70 ani (12).- radiografia toracica: anormalitati <strong>in</strong> jurul crosei aortice, diametru crescutal aortei ascen<strong>de</strong>nte.- diferente <strong>de</strong> tensiune arteriala <strong>in</strong>tre bratul stang si bratul drept.Figura 3. Algoritm durere toracica III (6)44Dureretoracica importantanonischemica60845Suspiciunecl<strong>in</strong>icaAnevrism AoDa46Echo/TEECTRMN la pacientstabil47DiagnosticAnevrism Aotip ADa48Consult chirurgiecardiovascularaNitroprusiat +esmolol/metoprololNuNu50EcgRx, gaze arterialesugestive pt. EPNuDa51Algoritmdiagnosticsitratament EP49Anevrism aortic tip BControl TA i FCNitroprusiat +esmolol/metoprololConsult chirurgiecardiovascularaInternare52Rx, gaze arterialesugestive pt. PtxDa53Drenaj toracicInternareNu54 55Semne sugestivept. pericarditaEchoDaTamponadacardiaca?Da56 57PericardiocentezaInternare terapieecho-ghidata<strong>in</strong>tensiva coronarieniNuNu59 58Cauze noncardiacevezi AlgoritmEcho negativTratamentExternareFigura 3. Algoritm durere toracica III (6)45. Investigatiile cl<strong>in</strong>ice sugereaza anevrism disecant <strong>de</strong> aorta sausimptomatic- semne cl<strong>in</strong>ice ale ischemiei afecteaza mai multe organe si sisteme (pot aparRecomandări şi Protocoale în Anestezie, Terapie Intensivă şi Medic<strong>in</strong>ă <strong>de</strong> Urgenţăneurologice, pareza ischemica, etc); durerea toracica d<strong>in</strong> disectia <strong>de</strong> aorta este <strong>de</strong>durere brusc <strong>in</strong>stalatã, cu maximum <strong>de</strong> <strong>in</strong>tensitate la <strong>de</strong>but (12). Durerea este <strong>de</strong>sfrecvent ca fi<strong>in</strong>d “ascutita” <strong>de</strong>cat sfasietoare, este o durere „<strong>in</strong>grozitoare” sau como „lovitura <strong>de</strong> pumnal”. In disectiile proximale durerea este localizata <strong>de</strong> obicei ret


46. Diagnosticul disectiei se confirma utilizand explorari imagistice (ClasaI, Nivel C) (12): angiografia tomografica computerizata / ecocardiografiatransesofagiana / rezonanta magnetica daca pacientul este stabil si asimptomatic.- Angiografia tomografica computerizata este <strong>in</strong> general cel mai rapid simai usor accesibil test diagnostic.- Ecocardiografia transesofagiana este un test diagnostic echivalent sipreferabil <strong>in</strong> cazul pacientilor cu <strong>in</strong>suficienta renala sau alergie la substanta<strong>de</strong> contrast.- Rezonanta magnetica nucleara ramane cel mai exact test, dar necesitaun pacient stabil. Ea trebuie evitata daca se suspecteaza o disectie aortica<strong>de</strong> tip A.609Tabel 5. Diagnosticul imagistic <strong>in</strong> disectia acuta <strong>de</strong> aorta (12).Recomandari I IIa IIb III1. Ecografia transtoracica urmata <strong>de</strong> ecocardiografia transesofagiana2. Tomografia computerizata• daca este cruciala <strong>de</strong>tectia rupturilor3. Angiografia <strong>de</strong> contrast• pentru <strong>de</strong>f<strong>in</strong>irea anatomica a cauzei hipoperfuziei viscerale• pentru ghidarea <strong>in</strong>terventiei percutane• la pacientii stabili hemod<strong>in</strong>amic• coronarografie preoperatorie <strong>de</strong> rut<strong>in</strong>a• la pacientii <strong>in</strong>stabili hemod<strong>in</strong>amic4. MRI• la pacientii <strong>in</strong>stabili hemod<strong>in</strong>amic5. Ecografia <strong>in</strong>travasculara• *pentru ghidarea <strong>in</strong>terventiilor percutaneNivel <strong>de</strong>evi<strong>de</strong>nta47. Precizarea diagnosticului <strong>de</strong> disectie <strong>de</strong> aorta sau anevrism simptomatic:Electrocardiograma efectuata la pacientul cu durere toracica si suspiciune<strong>de</strong> disectie <strong>de</strong> aorta se va <strong>in</strong>soti <strong>de</strong> modificari electrocardiografice <strong>de</strong> <strong>in</strong>farctmiocardic acut la aproximativ 20 % d<strong>in</strong> pacientii cu disectie <strong>de</strong> tip A, <strong>de</strong>un<strong>de</strong> riscul <strong>de</strong> a adm<strong>in</strong>istra terapie trombolitica cu efecte nocive la acestipacienti (12). Acesti pacienti cu suspiciune <strong>de</strong> disectie aortica si semne ECG<strong>de</strong> ischemie trebuie supusi unei explorari imagistice <strong>in</strong>a<strong>in</strong>te <strong>de</strong> adm<strong>in</strong>istrareatratamentului trombolitic (Clasa II, Nivel C). Procedura imagistica trebuie sa+++++++++++CCCCCCCCCCCTimisoara 2009


610stabileasca prezenta sau absenta unui anevrism sau prezenta si locatia oriabsenta unei disectii.48. Organizarea consultatiei <strong>de</strong> chirurgie cardiovasculara <strong>de</strong> <strong>urgenta</strong>.- Adm<strong>in</strong>istrarea <strong>de</strong> Nitroprusiat <strong>de</strong> sodiu + beta-blocant.- Interventia chirurgicala pentru anevrismul toracic simptomatic si disectiaproximala (tip A , tip I si II).- Controlati tensiunea arteriala cu nitroprusiat <strong>de</strong> sodiu <strong>in</strong> perfuzie (ClasaI, Nivel C) astfel <strong>in</strong>cat valoarea TA sistolice sa fie <strong>de</strong> 100-120 mmHg saubetablocante i.v (Clasa 1, Nivel C): esmolol, metoprolol, propranolol,labetalol- In caz <strong>de</strong> <strong>in</strong>stabilitate hemod<strong>in</strong>amica pacientul trebuie <strong>in</strong>tubat orotraheal,ventilat mecanic si dus <strong>in</strong> sala <strong>de</strong> operatie (12).49. Tratamentul disectiei distale. Disectia aortica distala (tip B, tip III) presupune<strong>in</strong> general terapie farmacologica (Clasa I, Nivel C)- perfuzii cu nitroprusiatsau beta-blocant pentru controlul tensiunii arteriale.- Aplicati terapia chirurgicala daca cea farmacologica nu are efect: existadurere persistenta si recurenta, expansiune precoce, complicatii ischemiceperiferice, ruptura (Clasa I, Nivel C) sau dacã persista ischemiamezenterica, renala sau a membrelor ori <strong>de</strong>ficitele neurologice (ClasaIIa, Nivel C).50. Simptomatologia, gazele sangv<strong>in</strong>e arteriale, radiografia toracica sugereazaembolia pulmonara?- Simptomele pot <strong>in</strong>clu<strong>de</strong> dispneea, durere toracica <strong>de</strong> tip pleural, dureretoracica substernala, tuse, s<strong>in</strong>copa, hemoptizie (11)- Semnele fizice extrem <strong>de</strong> variate pot <strong>in</strong>clu<strong>de</strong> tahipneea (> 20/m<strong>in</strong>),tahicardie (> 100/m<strong>in</strong>), semne <strong>de</strong> tromboza venoasa profunda, cianoza,febra- Simptomele apar la pacienti cu factori predispozanti pentru tromboembolismulvenos (traumatisme majore, fractura <strong>de</strong> sold sau membru<strong>in</strong>ferior, <strong>in</strong>terventii chirurgicale sau ortopedice majore, malignitate,imobilizare la pat, tratament chimioterapic sau hormonal, etc) (11)- Electrocardiograma <strong>in</strong>dica sub<strong>de</strong>nivelari <strong>de</strong> segment ST nespecifice- Radiografia toracica poate fi normala sau cu modificari- Valorile gazelor sangv<strong>in</strong>e arteriale prez<strong>in</strong>ta modificari (<strong>in</strong> special presiuneapartiala <strong>de</strong> oxigen PaO2)51. In cazul <strong>in</strong> care exista o suspiciune cl<strong>in</strong>ica <strong>de</strong> embolie pulmonara sust<strong>in</strong>uta<strong>de</strong> primele rezultate paracl<strong>in</strong>ice (ecg, radiografie toracica, gaze arteriale,d-dimeri <strong>in</strong> <strong>urgenta</strong>) se vor urma pasii <strong>de</strong> diagnostic, tratament sistratificare a riscului conform recomandarilor ghidului Societatii Europene<strong>de</strong> Cardiologie (11) pentru managementul emboliei pulmonareRecomandări şi Protocoale în Anestezie, Terapie Intensivă şi Medic<strong>in</strong>ă <strong>de</strong> Urgenţă


52. Simptomatologia, gazele sangv<strong>in</strong>e arteriale, radiografia toracica sugereazaun pneumotorax?Pneumotoraxul idiopatic sau spontan este sugerat <strong>de</strong> aparitia brusca a<strong>durerii</strong> <strong>toracice</strong> <strong>de</strong> tip pleural cu sau fara dispnee (durerea pleurala maiputernica <strong>in</strong> cazul pneumotorax mai mic, dispneea <strong>in</strong> cazul pneumotoraxmai mare). Ne referim <strong>in</strong> aceasta situatie la pneumotoraxul spontan la unpacient fara elemente anamnestice <strong>de</strong> trauma. Confirmarea diagnosticuluise va efectua pr<strong>in</strong> radiografie toracica si eventual pr<strong>in</strong> modificarile gazelorarteriale.53. Drenajul toracic <strong>in</strong> <strong>urgenta</strong> se va efectua imediat, iar pacientul va fi<strong>in</strong>ternat54. Simptomele/semnele sugereaza boala pericadica?- exista frecatura pericardica la auscultatia cordului- electrocardiograma <strong>in</strong>dica existenta unei supra<strong>de</strong>nivelari concave a segmentuluiST <strong>in</strong> teritoriul anterior si <strong>in</strong>ferior si <strong>de</strong>viatii ale segmentuluiPR <strong>in</strong> opozitie cu polaritatea un<strong>de</strong>i P; <strong>in</strong> evolutie supra<strong>de</strong>nivelarea rev<strong>in</strong>esi unda T se aplatizeaza si se <strong>in</strong>verseaza progresiv (13).Etiologie – <strong>in</strong>fectioasa, neoplastica, metabolica, afectiuni <strong>in</strong>flamatoriiautoimune, post<strong>in</strong>farct miocardic (s<strong>in</strong>dromul Dressler), <strong>in</strong>suficienta renalacronica.Legatura cu drogurile – hidralaz<strong>in</strong>a, proca<strong>in</strong>amida, isoniazida, fento<strong>in</strong>a,doxorubic<strong>in</strong>a.Luati <strong>in</strong> consi<strong>de</strong>rare traumatismele <strong>in</strong>chise <strong>toracice</strong>, statusul postoperator.Diagnosticul pericarditei se va face urmand pasii <strong>in</strong>dicati <strong>de</strong> ghidul SocietatiiEuropene <strong>de</strong> Cardiologie d<strong>in</strong> 2004 (13).55. Tamponada. Exista semnele unei tampona<strong>de</strong> cardiace?Durere toracica cu caracter <strong>de</strong> presiune <strong>in</strong>sotita <strong>de</strong> dispnee.Examen cl<strong>in</strong>ic: jugulare turgescente, hipotensiune arteriala, tahipnee, sca<strong>de</strong>reapresiunii pulsului, puls paradoxal mai mare <strong>de</strong> 20mmHg/.Electrocardiograma cu semne <strong>de</strong> alternanta electrica.Radiografie toracica: silueta cardiaca normala sau largita.Ecocardiografia: prezenta lichidului <strong>in</strong> spatiu pericardic > 50 ml, colapsdiastolic al peretelui liber anterior al ventriculului drept, atriului drept siatriului stang (13).In cazul acumularii acute, rapi<strong>de</strong> <strong>de</strong> lichid <strong>in</strong> pericard tamponada poateapare la o cantitate m<strong>in</strong>ima <strong>de</strong> 150 ml.56. Se va efectua pericardiocenteza - este <strong>in</strong>dicata punctia pericardicaeco-ghidata, daca exista posibilitati tehnice si competente.Daca ghidarea ecografica nu este disponibila sau pacientul este <strong>in</strong>stabilhemod<strong>in</strong>amic se va efectua punctia subxifoidiana.611Timisoara 2009


61257. Internare <strong>in</strong> terapie <strong>in</strong>tensiva cu monitorizare cardiaca cont<strong>in</strong>ua.58. Ecocardiografia efectuata <strong>in</strong> <strong>urgenta</strong> <strong>in</strong>dica o pericardita fara tamponada-pacientul poate fi spitalizat si se va <strong>in</strong>cepe tratamentul <strong>in</strong>flamatiei si56. Se va efectua pericardiocenteza - este <strong>in</strong>dicata punctia per<strong>durerii</strong> cu anti-<strong>in</strong>flamatorii nesteroidiene (Clasa I, Nivel B) si/sau colchic<strong>in</strong>adaca exista posibilitati tehnice si competente.(Clasa IIa, Nivel B). Daca Protectia ghidarea gastrica ecografica trebuie nu asigurata. este disponibila In cazul sau pacientului pacientul este <strong>in</strong>ststabil dupa consultul va efectua cardiologic, punctia acesta subxifoidiana. poate fi externat cu tratament <strong>in</strong>ambulator cu recomandari 57. <strong>de</strong> Internare restrictie <strong>in</strong> terapie a efortului <strong>in</strong>tensiva fizic si cu tratament monitorizare cu cardiaca anti<strong>in</strong>flamatori<strong>in</strong>esteroidiene. 58. Ecocardiografia efectuata <strong>in</strong> <strong>urgenta</strong> <strong>in</strong>dica o pericardcont<strong>in</strong>pacientul poate fi spitalizat si se va <strong>in</strong>cepe tratamentul <strong>in</strong>flamatie59. Cauzele non-cardiace pot fi si ele sursa <strong>durerii</strong> <strong>toracice</strong>.<strong>in</strong>flamatorii nesteroidiene (Clasa I, Nivel B) si/sau colchic<strong>in</strong>a (Clasa II60. Semne, simptome, gastrica imag<strong>in</strong>e trebuie radiologica asigurata. In ce cazul sugereaza pacientului o afectiune stabil pulmonarasau pleurala. poate fi externat cu tratament <strong>in</strong> ambulator cu recomandari <strong>de</strong> restricdupa consultuPacientii cu afectiuni tratament pleurale cu anti<strong>in</strong>flamatorii sau pulmonare nesteroidiene. au durere toracica <strong>in</strong>sotitasau nu <strong>de</strong> dispnee. Anamneza 59. Cauzele <strong>de</strong>taliata, non-cardiace examenul pot fizic, si electrocardiograma,sursa <strong>durerii</strong> <strong>toracice</strong>.60. Semne, simptome, imag<strong>in</strong>e radiologica ce sugereaza o aferadiografia toracica si rezultatele probelor <strong>de</strong> laborator (hematologie, biochimie)vor sust<strong>in</strong>e diagnosticul Pacientii pozitiv. cu afectiuni Diagnosticul pleurale sau diferential pulmonare se va au face durere toracipleurala.cu bronsita obstructiva dispnee. cronica Anamneza (BPOC), <strong>de</strong>taliata, astmul bronsic, examenul alte fizic, procese electrocardiograma, <strong>in</strong>fectioasesau maligne. rezultatele Precizarea probelor diagnosticului <strong>de</strong> laborator <strong>de</strong> pleurezie (hematologie, sau pneumonie biochimie) va vor sust<strong>in</strong>erfi urmata <strong>de</strong> tratament Diagnosticul <strong>in</strong> conformitate diferential cu se ghidurile. va face cu bronsita obstructiva cronica (BPalte procese <strong>in</strong>fectioase sau maligne. Precizarea diagnosticuluFigura 4. Algoritm durerepneumonietoracicavaIV (6).fi urmata <strong>de</strong> tratament <strong>in</strong> conformitate cu ghidurile.59Cauze noncardiace60Semne,simptome, Rx, sugestivept. afectiuni pleuralesau pulmonare?Da61Internare/observatieNu62Semne,simptome sugestivept. durere <strong>de</strong> perete/costocondrita?Da63AINS/tratament local/ambulatorNu64Afectiunigastro<strong>in</strong>test<strong>in</strong>ale?Da65EvaluaregastroenterologieNu66Reconsi<strong>de</strong>ratidiagnosticul diferentialFigura 4. Algoritm durere toracica IV (6).Recomandări şi Protocoale în Anestezie, Terapie Intensivă şi Medic<strong>in</strong>ă <strong>de</strong> Urgenţă61. Se <strong>de</strong>ci<strong>de</strong> <strong>in</strong>ternarea <strong>in</strong> spital sau ment<strong>in</strong>erea sub observatiePacientii cu durere toracica datorata afectiunilor pleurale sau ale parvor fi <strong>in</strong>ternati <strong>in</strong> functie <strong>de</strong> stabilitatea pacientului. Vor fi evaluate


61. Se <strong>de</strong>ci<strong>de</strong> <strong>in</strong>ternarea <strong>in</strong> spital sau ment<strong>in</strong>erea sub observatie.Pacientii cu durere toracica datorata afectiunilor pleurale sau ale parenchimuluipulmonar vor fi <strong>in</strong>ternati <strong>in</strong> functie <strong>de</strong> stabilitatea pacientului.Vor fi evaluate frecventa cardiaca, frecventa respiratorie, tensiunea arterialasi nivelul <strong>de</strong> constienta. Si alti factori vor fi luati <strong>in</strong> consi<strong>de</strong>rare <strong>in</strong> <strong>de</strong>cizia <strong>de</strong><strong>in</strong>ternare, respectiv: varsta, afectiuni preexistente, starea <strong>de</strong> imuno<strong>de</strong>presieeventual ale pacientului. Daca pacientul este <strong>in</strong>stabil hemod<strong>in</strong>amic sau curisc <strong>de</strong> a <strong>de</strong>veni <strong>in</strong>stabil va fi <strong>in</strong>ternat.62. Semnele, simptomele sugereaza o durere <strong>de</strong> perete toracic/costocondrita.Costrocondrita, nevralgia <strong>in</strong>tercostala sau alte dureri musculoscheletaresunt <strong>de</strong>stul <strong>de</strong> frecvente <strong>in</strong> etiologia <strong>durerii</strong> <strong>toracice</strong>. In aceste situatii pacientulpoate localiza durerea, care se refera la o arie <strong>de</strong>stul <strong>de</strong> precisa atoracelui. Examenul fizic va i<strong>de</strong>ntifica sediul <strong>durerii</strong> si va reproduce <strong>de</strong> obiceidurerea pr<strong>in</strong> palpare.63. Tratamentul pentru durerea <strong>de</strong> perete toracic si cea d<strong>in</strong> costocondritava fi efectuat cu anti<strong>in</strong>flamatorii nesteroidiene, iar <strong>in</strong> cazul unei dureri cronicese vor aplica recomandarile pentru managementul <strong>durerii</strong> cronice.64. Afectiune <strong>in</strong> sfera gastro-<strong>in</strong>test<strong>in</strong>ala?Daca au fost excluse cauzele <strong>in</strong>tra-<strong>toracice</strong> ale unei dureri <strong>toracice</strong>, cl<strong>in</strong>icianulse poate orienta spre o afectiune d<strong>in</strong> sfera digestiva cu rasunet asupratoracelui (ex. spasmul esofagian, esofagita, boala ulceroasa gastro-duo<strong>de</strong>nala,pancreatita, colecistita).65. Evaluare d<strong>in</strong> punct <strong>de</strong> ve<strong>de</strong>re gastro-enterologic, eventual consultgastro-enterologic.In cazul <strong>in</strong> care anamneza, examenul fizic si rezultatele <strong>de</strong> laborator vororienta medicul catre o afectiune gastro<strong>in</strong>test<strong>in</strong>ala se vor urmari pasii ghidurilorspecifice bolilor gastro-<strong>in</strong>test<strong>in</strong>ale.66. Reconsi<strong>de</strong>rati diagnosticul diferential.Nici unul d<strong>in</strong> diagnosticele anterioare nu a fost confirmat, <strong>in</strong> consec<strong>in</strong>tamedicul <strong>de</strong> <strong>urgenta</strong> va reconsi<strong>de</strong>ra examenul cl<strong>in</strong>ic si paracl<strong>in</strong>ic al pacientuluicu durere toracica.613Propunerea acestui protocol <strong>de</strong> <strong>abordare</strong> a pacientului cu durere toracicaare drept scop pr<strong>in</strong>cipal <strong>abordare</strong>a corecta si complexa a unei situatii cepoate avea cauze cardiace sau non-cardiace, unele implicand un risc vital <strong>in</strong>absenta diagnosticului si tratamentului <strong>de</strong> <strong>urgenta</strong>. Un raport <strong>de</strong> audit asupra<strong>de</strong>partamentelor <strong>de</strong> <strong>urgenta</strong> d<strong>in</strong> Marea Britanie a aratat ca 7 % d<strong>in</strong>trepacientii cu durere toracica externati d<strong>in</strong> <strong>de</strong>partamentul <strong>de</strong> <strong>urgenta</strong> prezentauo afectare miocardica severa (15). Pentru a reduce cat mai mult acestTimisoara 2009


procent si pentru a m<strong>in</strong>imaliza riscurile pentru pacienti consi<strong>de</strong>ram utila<strong>abordare</strong>a <strong>de</strong> <strong>urgenta</strong> pe baza protocoalelor, care permit utilizarea tuturorcunost<strong>in</strong>telor medicale si simtului cl<strong>in</strong>ic al medicului <strong>in</strong>tr-o formula algoritmica,bazata pe rezultatele studiilor cl<strong>in</strong>ice si op<strong>in</strong>ia expertilor, ce pot ficont<strong>in</strong>uu imbunatatite.Bibliografie6141. Erhardt L, Herlitz , Bossaert L, et al. Task force on management of chest pa<strong>in</strong>. European Heart Journal.2002; 23: 1153-76.2. Van <strong>de</strong> Werf F, Bax J, Betriu A, et al. Management of acute myocardial <strong>in</strong>farction <strong>in</strong> patients present<strong>in</strong>gwith persistent ST- segment elevation. Eur Heart J 2008; 29:2909-45.3. Antman EM, Anbe DT, Armstrong PW, et al. ACC/AHA Gui<strong>de</strong>l<strong>in</strong>es for the Management of Patients withST-Elevation Myocardial Infarction, 2004.4. Tatu-Chitoiu G, Petris A, Deleanu D, et al. Ghid <strong>de</strong> diagnostic si tratament <strong>in</strong> faza <strong>de</strong> pre-spital al <strong>in</strong>farctuluimiocardic acut cu supra<strong>de</strong>nivelare <strong>de</strong> segment ST. Bucuresti: Curtea Veche, 2009.5. European Resuscitation Council Gui<strong>de</strong>l<strong>in</strong>es for Resuscitation, 2005.6. Institute for Cl<strong>in</strong>ical Systems. Improvement Diagnosis and Treatment of Chest Pa<strong>in</strong> and ACS FourthEdition/October 2008.7. Consiliul National Roman <strong>de</strong> Resuscitare. Resuscitarea cardiopulmonara si cerebrala la adult- note <strong>de</strong>curs. Bucuresti, Ed. Alpha MDN, 2006 si 2008.8. Cimpoesu-Preotu DC. Ghiduri si Protocoale <strong>in</strong> Medic<strong>in</strong>a <strong>de</strong> Urgenta, Iasi, Ed. PIM, 2007.9. Bassand JP, Hamm GW, Ardiss<strong>in</strong>o D. Gui<strong>de</strong>l<strong>in</strong>es for the diagnosis and treatment of non-ST-segmentelevation acute coronary syndromes. European Heart Journal 2007; 28:1598-660.10. Fox K, Garcia MAA, Ardiss<strong>in</strong>o D, et al. Gui<strong>de</strong>l<strong>in</strong>es on the management of stable ang<strong>in</strong>a pectoris: execitivesummary. Eur. Heart J. 2006; 27:1341-81.11. Torbiki A, Perrier A, Konstant<strong>in</strong>i<strong>de</strong>s S. Gui<strong>de</strong>l<strong>in</strong>es on the management of acute pulmonary embolism.European Heart Journal 2008; 29:2276-315.12. Erbel R, Alfonso F, Boileau C, et al. Diagnosis and management of aortic dissection. European HeartJournal 2001; 22:1642–81.13. Maisch B, Seferovic PM, Ristic AD. Gui<strong>de</strong>l<strong>in</strong>es on the diagnosis and management of pericardial diseases.European Heart Journal 2004; 25: 587-610.14. Antman EM, Hand M, Armstrong PW, et al. 2007 Focused update of the ACC/AHA 2004 ACC/AHA Gui<strong>de</strong>l<strong>in</strong>esfor the Management of Patients with ST-Elevation Myocardial Infarction, 2007.15. Coll<strong>in</strong>son PO, Premachandram S, Hashemi K. Prospective audit of <strong>in</strong>ci<strong>de</strong>nce of prognostically importantmyocardial damage <strong>in</strong> patients discharged from emergency <strong>de</strong>partment. BMJ 2000; 320:1702-5.Recomandări şi Protocoale în Anestezie, Terapie Intensivă şi Medic<strong>in</strong>ă <strong>de</strong> Urgenţă

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