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2007, nr. 3 - Academia de Ştiinţe a Moldovei

2007, nr. 3 - Academia de Ştiinţe a Moldovei

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sing idiopathic pulmonary fi brosis histology by objective morphometric in<strong>de</strong>x // Pathol. Res. Pract.,2002; 198: 347-54.27. Selman M., King T.E., Pardo A., Idiopathic pulmonary fi brosis: prevailing and evolvinghypotheses about its pathogenesis and implications for therapy //Ann. Internal. Med., 2001; 134:136-51.28. Selman M., Lin H.M., Montano M., Jenkins A.L., Estrada A., Lin Z. et al., Surfactant proteinA and B genetic variants predispose to idiopathic pulmonary fi brosis //Hum. Genet, 2003;113:542-50.29. To<strong>de</strong>a D., Cohruţ S., Orientări diagnostice şi terapeutice în fi broza pulmonară idiopatic //Pneumologia, 2002;LI(3):222-9.30. Turner-Warwick M., Burrows B., Johnson A., Cryptogenic fi brosing alveolitis: clinical featuresand their infl uence on survival //Thorax., 1980;35:171-80.31. Utz J.P., Ryu J.H., Douglas W.W., Tazelaar H.D., Myers J.L., Allen M.S. et al., High short-termmortality following lung biopsy for usual interstitial pneumonia //Eur. Respir. J., 2001;17:175-9.32. Whyte M., Hubbard R., Meliconi R., Whidborne M., Eaton V., Bingle C. et al., Increasedrisk of fi brosing alveolitis associated with interleukin-1 receptor antagonist and tumor necrosis factor-alphagene polymorphisms //Am. J. Respir. Crit .Care Med., 2000;162(2 Pt 1):755-8.33. Xu Y.D., Hua J., O’Connor R., Khalil N., Chronic release of active TFG-beta1 by alveolarepithelial cell (AEC) line, L-2 results in connective tissue (CT) synthesis and conversion of L-2 cellsto a fi broblast-like phenotype //Am. J. Respir. Crit. Care Med., 2003;167:A572.34. Zorzetto M., Ferrarotti I., Trisolini R. et al., Complement receptor 1 gene polymorphismsare associated with idiopathic pulmonary fi brosis //Am. J. Respir. Crit. Care Med., 2003;168:330-4.35. Путов Н.В., Илькович М.М., Фиброзирующие альвеолиты //Ленинград, 1986, 168с.36. Чучалин А.Г., Котляров П.М., Георгиади С.Г., Рентгенография и компьютернаятомография в диагностике различных видов идиопатических интерстициальных пневмоний//Пульмонология, 2003, 3:89-95RezumatPneumonitele interstiţiale idiopatice sunt un grup heterogen <strong>de</strong> afecţiuni cu etiologie necunoscută,care <strong>de</strong>curg cu afectarea difuză a interstiţiului pulmonar, cu un patern variat <strong>de</strong> inflamaţie şi fibroză.În articol au fost reflectate abordările contemporane ale fibrozei pulmonare idiopatice – etiologia,patogenia, clasificarea, diagnosticarea şi evaluarea pacienţilor cu această patologie.SummaryThe idiopathic interstitial pneumonias are a heterogeneous group of diffuse parenchymal diseasesof unknown etiology, which are characterized by varying patterns of inflammation and fibrosis ofthe lung parenchyma found on a surgical lung biopsy specimen. A <strong>de</strong>finitive diagnosis of idiopathicpulmonary fibrosis requires a histologic pattern of usual interstitial pneumonia We provi<strong>de</strong> a focusedupdate of the pathogenesis, diagnosis and evaluation of this <strong>de</strong>sease.202UTILIZAREA SISTEMELOR DE RADIOGRAFIE DIGITALĂ ÎNRESPIROLOGIENa<strong>de</strong>jda Pisarenco, dr. în medicină, conf. univ., IMSP Spitalul Clinic Municipal <strong>de</strong>FtiziopneumologieÎn prezent imaginile radiologice se obţin folosind un spectru vast <strong>de</strong> meto<strong>de</strong> diferite, incluzândtehnologiile analoge directe, analoge indirecte şi digitale.Principiul <strong>de</strong> bază al tehnologiei analoge directe, la care se referă radiografia şi radioscopia,constă în aceea că conţinutul informaţional al obiectului se formează pe filmul radiologic sau pe ecra-

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