Identificarea profilelor moleculare transcriptomice in cancerul de col ...

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Activitati prevazute pt 2011:Perspective 2011Realizarea studiului de genomica (hibridarea sondelor microarray pelame WHG (4x44k); validarea rezultatelor microarray prin qRT-PCR;corelarea datelor de genomica cu subtipul viral HPV si raspunsul laterapie;Obiectivele preconizate a fi atinse:Realizarea unui model experimental, bazat pe studii de genomicafunctionala si genotipare HPV, ca factor de predictie in raspunsul laradio- chimioterapie in cancerul de col uterin (IIB-IIIB).Elemente de originalitate:Combinarea analizei transcriptomice cu genotiparea HPV (37 subtipuri)Necesar finantare pt 2011:Ramas din contractare: 1.533.355 leiAtingerea obiectivelor propuse initial: 650.000-700.000 lei
Perspective: HPV- genomica-genotipareName ofGeneCDH5FGFR3(VEGFR)KDRNOTCH4PLAUSTAB1THBS1Descriptioncadherin 5, type 2 (vascular endothelium)fibroblast growth factor receptor 3, mitogeneza sidiferentierekinase insert domain receptor (a type III receptortyrosine kinase); receptor for VEGFNotch homolog 4 (Drosophila), developementplasminogen activator, urokinase; involved indegradation of the extracellular matrix and possiblytumor cell migration and proliferationstabilin 1; function in angiogenesis, lymphocytehoming, cell adhesion, or receptor scavengingthrombospondin 1; angiogenesis, and tumorigenesisFold Up- or Down- regulationHPV16/HPV45, 58 p value3.22210.00050210.73810.0041662.6970.0143913.70120.001723.35120.0187631.58520.0283173.65870.037926
Page 1 and 2: Nr proiect: 42-160/ 2008Titlul Proi
Page 3 and 4: Obiectiv: Realizarea unui model exp
Page 5 and 6: Participare tineri cercetatoriDomen
Page 7: Indicatori de rezultat realizati in

Identificarea profilelor moleculare transcriptomice in cancerul de col ...

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