RevistÄ de MedicinÄ Åi Farmacie - Clujul Medical - Iuliu HaÅ£ieganu
RevistÄ de MedicinÄ Åi Farmacie - Clujul Medical - Iuliu HaÅ£ieganu
RevistÄ de MedicinÄ Åi Farmacie - Clujul Medical - Iuliu HaÅ£ieganu
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Patologie osteoarticulară<br />
9. Cronstein BN: Interleukin-6. A key mediator of systemic and<br />
local symptoms in rheumatoid arthritis, Bull NYU Hosp Joint Dis,<br />
2007, 65, Suppl 1,S 11-5.<br />
10. Naka T, Nishimoto N, Kishimoto T: The paradigm of IL-6:<br />
from basic science to medicine, Arthritis Res, 2002, 4, Suppl 3,<br />
S233-242.<br />
11. Nishimoto N, Kishimoto T: Interleukin 6: From bench to<br />
bedsi<strong>de</strong>, Nat Clin Pract Rheumatol, 2006, 2, 619-626.<br />
12. Nishimoto N, Yoshizaki K, Miyasaka N et al.: Treatment of<br />
rheumatoid arthritis with humanized anti-interleukin-6 receptor<br />
antibody: A multicenter, double blind, placebo-controlled trial,<br />
Arthritis Rheum, 2004, 50, 1761-1769.<br />
13. Smolen JS, Beaulieu A, Rubbert –Roth A et al.: Effect of<br />
interleukin-6 receptor inhibition with tocilizumab in patients with<br />
rheumatoid arthritis (OPTION study): a double-blind,placebo<br />
controlled, randomized trial, Lancet 200, 371, 97-997.<br />
14. Maini RN, Taylor PC, Szechinski J et al.: Double –blind<br />
randomized controlled clinical trial of the interleukin-6 receptor<br />
antagonist , tocilizumab, in European patients with rheumatoid<br />
arthritis who had an incomplete response to methotrexate, Arthritis<br />
Rheum, 2006, 54, 217-219.<br />
15. Sutherland AP, Mackay F, Mackay CR: Targeting BAFF:<br />
immunomodulation for autoimmune disease and lymphomas,<br />
Pharmacol Ther, 2006, 112, 774-76.<br />
16. Katselenson N, Kanswal S, Puig M, Mostowsk H, Verthelyi<br />
D, Akkoyunlu M: Synthetic CpG oligo <strong>de</strong>oxinucleoti<strong>de</strong>s augment<br />
BAFF- and APRIL-mediated immunoglobulin secretion, Eur J<br />
Immunol, 2007, 37, 175- 1795.<br />
17. Zhang M, Ko KH ,Lam QL et al. Expression and function of<br />
TNF family member B cell –activating factor in the <strong>de</strong>velopment<br />
of autoimmune arthritis, Int Immunol, 2005, 17, 101-1092.<br />
1. Do RK, Chen-Kiang S: Mechanism of BLyS action in cell<br />
immunity, Cytokine Growth Factor Rev, 2002, 13, 19-25.<br />
19. Sun J, Lin Zeno, Feng J, Li Y, Sen B: BAFF-targeting<br />
therapy, a promising strategy for treating autoimmune diseases,<br />
Eur J Pharmacol, 200, 597, 1-5.<br />
20. Seyler TM, Park YW, Takemura S et al.: BLyS and APRIL<br />
in rheumatoid arthritis, J Clin Invest, 2005, 115, 303-3092.<br />
21. McKay J: Belimumab (BmAb), a fully human monoclonal<br />
antibody to B-lymphocyte stimulator (BlyS), combined with<br />
standard of care therapy reduces the signs and symptoms of<br />
rheumatoid arthritis in a heterogenous subject population. Arthritis<br />
Rheum, 2005, 52, Suppl 9, S 710-S 711.<br />
22. Tak PP, Thurlings RM, Rossier et al.: Atacicept in patients<br />
with rheumatoid arthritis:results of a multicenter, phase 1b, double<br />
blind, placebo- controlled, dose-escalading,single- and repeated<br />
dose study, Arthritis Rheum, 200, 5, 61-72.<br />
23. Tsokos GC: B cells , be gone –B-cell <strong>de</strong>pletion in the treatment<br />
of rheumatoid arthritis, N Engl J Med, 2004, 350, 2546-254.<br />
24. Lam QLK, Ko OKH, Zheng B-J, Lu L: Local BAFF gene<br />
silencing suppresses Th 17-cell generation and ameliorates<br />
autoimmune arthritis, Proc Nat Acad Sci USA, 200, 105, 14993-<br />
1499.<br />
25. Firestein GS, Zvaifler NJ: How important are T cells in chronic<br />
rheumatoid synovitis? II .T cell –in<strong>de</strong>pen<strong>de</strong>nt mechanisms from<br />
beginning to end. Arthritis Rheum, 2002, 46, 2930.<br />
26. Baslund B, Tve<strong>de</strong> N, Danneskiold M, Samsoe B et al.:<br />
Targeting interleukin -15 in patients with rheumatoid arthritis :a<br />
proof- of- concept study, Arthritis Rheum, 2005, 52, 266-292.<br />
342<br />
<strong>Clujul</strong> <strong>Medical</strong> 2009 Vol. LXXXII - nr. 3