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Jurnalul Român <strong>de</strong> Psih<strong>of</strong>armacologie<br />

Romanian Journal <strong>of</strong> Psychopharmacology<br />

Vol. 6, Nr. 1, 2<br />

Aceste date clinice pot fi corelate semnificativ cu potenţiali markeri biologici pentru<br />

comportamentul suicidar: nivel scăzut al L-tript<strong>of</strong>anului, scă<strong>de</strong>rea 5-HIAA în LCR şi nivel MAO<br />

plachetar scăzut.<br />

Evaluarea riscului <strong>de</strong> comportament suicidar rămâne o problemă mereu actuală, iar metodologia<br />

propusă <strong>de</strong> noi în scopul obiectivării acestuia permite instituirea unor măsuri <strong>de</strong> pr<strong>of</strong>ilaxie primară sau<br />

secundară, bazată pe elemente obiective neurobiologice şi psih<strong>of</strong>armacologice.<br />

Bibliografie selectivă<br />

1. Caldwell, C., Gottesman, I., 1990 – Schizophrenics kill themselves too: a review <strong>of</strong><br />

risk factors for suici<strong>de</strong>. Schizophr. Bull., 16, 571-589.<br />

2. Cunningham-Owens, D.G. et al, 2001 – A randomized, controlled trial <strong>of</strong> a brief<br />

interventional package for schizophrenia out-patients. Acta Psychiat. Scand., 103, 362-369.<br />

3. Foster, T., Gillespie, K., McClelland, R., Patterson, C., 1999 – Risk factors for suici<strong>de</strong><br />

in<strong>de</strong>pen<strong>de</strong>nt <strong>of</strong> DSM-II-R Axis I disor<strong>de</strong>r. Brit. J. Psychiat., 175, 175-179.<br />

4. Hannele, H. et al, 1999 – Life events and completed suici<strong>de</strong> in schizophrenia: a<br />

comparison <strong>of</strong> suici<strong>de</strong> victims with and without schizophrenia. Schizophr. Bull., 25, 3.<br />

5. Harris, E.C., Barraclough, B., 1998 – Excess mortality <strong>of</strong> mental disor<strong>de</strong>r. Brit. J.<br />

Psychiat., 173, 11-53.<br />

6. Haw, C.M., 2005 – Lifetime risk <strong>of</strong> suici<strong>de</strong> in people with schizophrenia lower that<br />

commonly reported. Evid. Based Ment. Health, 8, 96.<br />

7. Johnstone, C., Owens, D.G., Crown, T.J., 1986 – Relative stability <strong>of</strong> positive and<br />

negative features in chronic schizophrenia. Brit. J. Psychiat., 150, 60-64.<br />

8. Kane, J.M., Dauphinais, D. et al, 1993 – Assessing negative symptoms and extrapyramidal<br />

symptoms in schizophrenia: workshop report. Schizophr. Bull., 29, 1, 43-45.<br />

9. Leff, J., 1990 – Depressive symptoms in the course <strong>of</strong> schizophrenia. In: Depression and<br />

Schizophrenia, ed. L.E. DeLisi, American Psychiatric Press, Washington DC, 1-25.<br />

10. Marinescu, D., 1997 – Tratamentul mo<strong>de</strong>rn al schiz<strong>of</strong>reniei şi psihozelor afective. Ed.<br />

AIUS Craiova, 101-110.<br />

11. Meltzer, H.Y., Okayli, G., 1995 – Reduction <strong>of</strong> suicidality during clozapine treatment<br />

<strong>of</strong> neuroleptic resistant schizophrenia: impact on risk-benefit assessment. Am. J.<br />

Psychiat., 152, 183-190.<br />

12. Sinclair, J.M.A., Mullee, M.A., King, E.A., Baldwin, D.S., 2004 – Suici<strong>de</strong> in schizophrenia:<br />

a retrospective case-control study <strong>of</strong> 51 suici<strong>de</strong>s. Schizophr. Bull., 30, 803-811.<br />

13. Siris, S.G., 1995 – Depression and schizophrenia. In: Schizophrenia, ed. S.R. Hirsch,<br />

D.R. Weinberger, Blackwell, Oxford, 184-221.<br />

14. Zăvoi, R., Udriştoiu, T., Marinescu, D., 2007 – Elemente <strong>de</strong> psihiatrie medico-legală.<br />

Ed. Medicală Universitară, Craiova, 203-210.<br />

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