Clujul Medical - Iuliu Haţieganu

Clujul Medical 2006 vol. LXXX - nr. 1
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New issues in varicose disease pathogeny
CLAUDIA GHERMAN, DIANA SĂCUI, LAURA PALCĂU
Summary
The varicose disease, a pathology chapter of permanent interest, represents a
nosological evolutive entity. The damage of the venous wall, the valvular insufficiency
or the deep venous thrombosis among the patient’s pathological antecedents cause
venous reflux, which at its turn generates venous hypertension, venous stasis and tissue
hypoxia.
The disorganization of the smooth muscle cells and of the extracellular matrix
components of the varicose vein is present. Other biological parameters, growth factors,
apoptosis mechanisms seem to be involved in the pathogeny of the varicose disease.
The inflammatory reactions play an essential role in the genesis of varicose ulcers.
The survey concludes the fact that the pathogenic mechanism of the varicose
disease, the most common occurrence of chronic venous insufficiency, are still in
debate. An important aspect resides in the study of the genetic factors involved in the
onset of the varicose disease, intending to establish a true genetic profile of the varicose
patient.
Keywords: varicose veins, parietal remodeling, collagen, genetic predisposition
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