Clujul Medical - Iuliu Haţieganu

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Clujul Medical 2006 vol. LXXX - nr. 1 9. SANSILVESTRI-MOREL P, RUPIN A, BADIER-COMMANDER C, Kern P, FABIANI J-N, VERBEUREN TJ, VANHOUTTE PM: Imbalance in the synthesis of collagen type I and collagen type III in smooth muscle cells derived from human varicose veins. J Vasc Res 2001; 38: 560-568. 10. SANSILVESTRI-MOREL P, RUPIN A, Jaisson S, FABIANI J-N, VERBEUREN TJ, VANHOUTTE PM: Synthesis of collagen is dysregulated in cultured fibroblasts derived from skin of subjects with varicose veins as it is in venous smooth muscle cells. Circulation 2002; 106: 479-483. 11. SANSILVESTRI-MOREL P, RUPIN A, BADIER-COMMANDER C, FABIANI J-N, VERBEUREN TJ: Chronic venous insufficiency: dysregulation of collagen synthesis: Angiology 2003; 54: S13-S18. 12. WOODSIDE KJ, HU M, BURKE A, MURAKAMI M, POUNDS LL, KILLEWICH LA, DALLER JA, HUNTER GC: Morphologic characteristics of varicose veins: possible role of metalloproteinases. J Vasc Surg. 2003 Jul; 38 (1): 162-9. 13. BUJAN J, JURADO F, GIMENO MJ, GARCIA-HONDUVILLA N, PASCUAL G, JIMENEZ J, BELLON JM: Changes in metalloproteinase (MMP1, MMP2) expression in the proximal region of the varicose saphenous vein wall in young subjects. Phlebology 2000; 15: 64-70. 14. SANSILVESTRI-MOREL P, RUPIN A, JULLIEN ND, LEMBREZ N, MESTRIES-DUBOIS P, FABIANI JN, VERBEUREN TJ.: Decreased production of collagen Type III in cultured smooth muscle cells from varicose vein patients is due to a degradation by MMPs: possible implication of MMP-3. J Vasc Res. 2005 Sep-Oct; 42 (5): 388-98. 15. GILLESPIE DL, PATEL A, FILETA B, CHANG A, BARNES S, FLAGG A, KIDWELL M, VILLAVICENZIO JL, RICH NM: Varicose veins possess greater quantities of MMP1 than normal veins and demonstrate regional variation in MMP1 and MMP13. J Surg Res 2002; 106: 233-238. 16. KOWALEWSKI R, SOBOLEWSKI K, WOLANSKA M, GACKO M: Matrix metalloproteinases in the vein wall. Int Angiol 2004; 23: 164-169. 17. BADIER-COMMANDER C, COUVELARD A, HENIN D, VERBEUREN T, MICHEL JB, JACOB MP. Smooth muscle cell modulation and cytokine overproduction in varicose veins. An in situ study. J Pathol. 2001 Mar; 193 (3): 398-407. 18. JACOB T, HINGORANI A, ASCHER E. Overexpression of transforming growth factor-beta1 correlates with increased synthesis of nitric oxide synthase in varicose veins. J Vasc Surg. 2005 Mar; 41 (3): 523-30. 19. DUCASSE E, GIANNAKAKIS K, CHEVALIER J, DASNOY D, PUPPINCK P, SPEZIALE F, FIORANI P, FARAGGIANA T. Dysregulated apoptosis in primary varicose veins. Eur J Vasc Endovasc Surg. 2005 Mar; 29 (3): 316-23. 20. LIJNEN HR: Plasmin and Matrix metalloproteinases in vascular remodeling. Thromb Haemost 2001; 86: 324-333. 21. CULLEN JP, NICHOLL SM, SAYEED S, SITZMANN JV, OKADA SS, CAHILL PA, REDMOND EM. Plasminogen activator inhibitor-1 deficiency enhances flow-induced smooth muscle cell migration.Thromb Res. 2004; 114 (1): 57-65. 22. VELLING T, RISTELI J, WENNERBERG K, MOSHER DF, JOHANSSON S: Polymerization of type I and III collagens is dependent on fibronectin and enhanced by integrins 11 1 and 2 1. J Biol Chem 2002; 277: 37377-37381. 23. BERTRAND-THIEBAULT C, FERRARI L, BOUTHERIN-FALSON O, KOCKX M, DESQUAND-BILLIALD S, FICHELLE JM, NOTTIN R, RENAUD JF, BATT AM, VISVIKIS S. Cytochromes P450 are differently expressed in normal and varicose human saphenous veins: linkage with varicosis. Clin Exp Pharmacol Physiol. 2004 May-Jun; 31 (5-6): 295-301. 34
Clujul Medical 2006 vol. LXXX - nr. 1 24. LEE S, LEE W, CHOE Y, KIM D, NA G, IM S, KIM J, KIM M, KIM J, CHO J. Gene expression profiles in varicose veins using complementary DNA microarray. Dermatol Surg. 2005 Apr; 31 (4): 391-5. 25. PISTORIUS MA: Chronic venous insufficiency: the genetic influence: Angiology 2003; 54: S5-S12. 26. KIM DI, EO HS, JOH JH.: Identification of differentially expressed genes in primary varicose veins. J Surg Res. 2005 Feb; 123 (2): 222-6. 27. PASCARELLA L, PENN A, SCHMID-SCHONBEIN GW. Venous hypertension and the inflammatory cascade: major manifestations and trigger mechanisms. Angiology. 2005 Sep-Oct; 56 Suppl 1: S3-10. 28. SHVAL'B PG, GRIAZNOV SV, SHVAL'B AP.Some aspects of the pathogenesis of trophic venous ulcers.Angiol Sosud Khir. 2005; 11 (1): 61-4. New issues in varicose disease pathogeny CLAUDIA GHERMAN, DIANA SĂCUI, LAURA PALCĂU Summary The varicose disease, a pathology chapter of permanent interest, represents a nosological evolutive entity. The damage of the venous wall, the valvular insufficiency or the deep venous thrombosis among the patient’s pathological antecedents cause venous reflux, which at its turn generates venous hypertension, venous stasis and tissue hypoxia. The disorganization of the smooth muscle cells and of the extracellular matrix components of the varicose vein is present. Other biological parameters, growth factors, apoptosis mechanisms seem to be involved in the pathogeny of the varicose disease. The inflammatory reactions play an essential role in the genesis of varicose ulcers. The survey concludes the fact that the pathogenic mechanism of the varicose disease, the most common occurrence of chronic venous insufficiency, are still in debate. An important aspect resides in the study of the genetic factors involved in the onset of the varicose disease, intending to establish a true genetic profile of the varicose patient. Keywords: varicose veins, parietal remodeling, collagen, genetic predisposition 35
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