Clujul Medical - Iuliu Haţieganu

More documents

Recommendations

Info

Clujul Medical 2006 vol. LXXX - nr. 1 Phrenic nerves and diaphragm (Second part). Diaphragm pacing. FR.GRIGORESCU SIDO, ANCA ZIMMERMANN Summary The phrenic nerve (FN) and the diaphragm (D) are a morphofunctional unit with an important role in the physiology and pathology of respiration, digestion and circulation. The anatomy of intradiaphragmatic branches of the phrenic nerve was intensively researched by anatomists and surgeons between 1950-1990, with the aim to perform the most sparing phrenotomy possible. After 1990, the research was mainly focused on the identification of the phrenic nerve motor points to allow diaphragmatic pacing with laparoscopically placed electrods in the diaphragm in patients with chronic respiratory distress (e.g. central hypoventilation, tetraplegia, etc.), who were on mechanical ventilation. The present study analyses, on 58 anatomical preparations, the phrenic nerve anatomical points with the intention to identify on human being the bilateral phrenic nerve motor points to facilitate better diaphragmatic pacing procedures. Key words: phrenic nerves, diaphragm, diaphragm pacing. Abbreviations: D (diaphragm), FN (phrenic nerve). 124
ANTIALLERGIC ACTIVITY OF SUBSTITUTED BENZAMIDES: CHARACTERIZATION, ESTIMATION AND PREDICTION L. JÄNTSCHI 1 , SORANA-DANIELA BOLBOACĂ 2 1 Technical University of Cluj-Napoca, Romania 2 ”Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania, Summary Antiallergic activity of twenty-three substituted N 4-methoxyphenyl benzamides was model by the use of an original methodology. After sketching out the compounds structure and creating the file with the observed activities, strictly based on compounds structure, the molecular descriptors family was generated and descriptors entered into a multiple linear regression analysis. The multi-varied model with four descriptors proved to render higher ability in estimation (squared correlation coefficient, r 2 = 0.9986) as well as in prediction (cross-validation leave-one-out score, r 2 cv-loo = 0.9956) of antiallergic activity of compounds, obtained significantly greater correlation coefficient compared with the previously reported model (p < 0.01). Characterization of antiallergic activity of substituted N 4-methoxyphenyl benzamides by integration of complex structure information provides a stable and efficient multivaried model with four descriptors. According with the multi-varied model with four descriptors the antiallergic activity of substituted N 4-methoxyphenyl benzamides is like to be of geometry nature, depending by the number of directly bonded hydrogen’s, and the atomic relative mass, being in relation with the partial charge of compounds Keywords: Molecular Descriptors Family on Structure-Activity Relationships (MDF-SAR), Substituted N 4-methoxyphenyl benzamides, Antiallergic activity, Multiple linear regression (MLR) Background Benzamide derivatives, known for their anti-inflammatory and immunomodulatory [1,2], anti-tumoral [3], antipsychotic [4], and antiallergic [5] activities, are drugs widely used in medicine [6]. Twenty-three derivatives of N 4-methoxyphenyl benzamide were previously synthesized and their antiallergic activity was tested using dinitrochlorobenzene by inducing delayed allergy of rat skin in vivo [5]. The inhibitory tumor swell rate (IR) was model by the use of molecular connectivity indices, and the following equation was obtained: log IR=3.002+0.8909 4 xp-1.3465 5 xp-13.8234 6 xcg (1) where logIR is inhibitory rate expressed in logarithm scale, and 4 xp, 5 xp, 6 xcg are molecular connectivity indices. The statistical characteristics of previously reported model [5] are: r = 0.8865, F = 23, s = 0.572, n = 23 (2) where r = correlation coefficient, F = parameter of Fisher-test, s = standard deviation, and n = sample size. 125
Page 1 and 2:
Clujul Medical Revistă de Medicin
Page 3 and 4:
Articole de orientare Clujul Medica
Page 5:
VOICHITA SĂBĂDUŞ, D. BORZEA, DIA
Page 8 and 9:
CAMELIA GEORGETA RĂCĂREANU, GABRI
Page 11 and 12:
Articole de orientare ROLUL NEUROKI
Page 13 and 14:
Clujul Medical 2006 vol. LXXX - nr.
Page 15 and 16:
Page 17 and 18:
DETECŢIA REARANJAMENTELOR SUBTELOM
Page 19 and 20:
Page 21 and 22:
Page 23 and 24:
Page 25 and 26:
Page 27 and 28:
Page 29 and 30:
ACTUALITĂŢI ÎN PATOGENIA BOLII V
Page 31 and 32:
Page 33 and 34:
Page 35 and 36:
Page 37 and 38:
Page 39 and 40:
Page 41 and 42:
Page 43 and 44:
Page 45 and 46:
Page 47 and 48:
Cercetare clinică EARLY COURSE OF
Page 49 and 50:
Page 51 and 52:
Page 53 and 54:
Page 55 and 56:
Page 57 and 58:
Page 59 and 60:
Page 61 and 62:
Page 63 and 64:
Page 65 and 66:
Page 67 and 68:
Page 69 and 70:
Page 71 and 72:
Page 73 and 74: Clujul Medical 2006 vol. LXXX - nr.
Page 79 and 80: APORTUL BIOPSIEI HISTOLOGICE ECOGHI
Page 103 and 104: ASOCIEREA TULBURĂRILOR DIGESTIVE F
Page 109 and 110: NEUTROPENII ASOCIATE CU ANEMII APLA
Page 123: Clujul Medical 2006 vol. LXXX - nr.
Page 133 and 134: Cazuri clinice ACUTE MEGAKARYOCYTIC
Page 137 and 138: POLYSEROSITIS AND MULTISYSTEMIC DYS
Page 143 and 144: Medicină dentară ASPECTE MORFOPAT
Page 157 and 158: PARTICULARITĂŢI ÎN CONCEPEREA PR
Page 163 and 164: CITOKINE PROINFLAMATORII ÎN BOALA
Page 169 and 170: CONTRIBUŢII LA AMPRENTELE FONETICE
Page 175 and 176:
Page 177 and 178:
Page 179 and 180:
Page 181 and 182:
Farmacie STUDII ASUPRA STRUCTURII M
Page 183 and 184:
Page 185 and 186:
Page 187 and 188:
Page 189 and 190:
Page 191 and 192:
Page 193 and 194:
Page 195 and 196:
STUDIU PRIVIND ACHIZIŢIA MEDICAMEN
Page 197 and 198:
Nr. crt. Clujul Medical 2006 vol. L
Page 199 and 200:
Page 201 and 202:
Page 203 and 204:
CERCETĂRI PRELIMINARE ASUPRA COMPU
Page 205 and 206:
Page 207 and 208:
Page 209 and 210:
Idei în medicină CERCETAREA ŞTII
Page 211 and 212:
show all

Clujul Medical - Iuliu Haţieganu

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?