Junções Celulares, Adesão Celular ea Matriz Extracelular

Prof. Marcio Alvarez Silva
Junções Celulares, Adesão
Celular e a Matriz Extracelular
BEG5101 A, B, C

• Das interações sociais entre as células em
organismos multicelulares, a adesão é
fundamental;
• Os mecanismos de coesão garantem a
arquitetura do organismo: junções, adesão
entre células e entre a matriz extracelular.

Os dois principais modos de
organização tissular
Figure 19-1 Molecular Biology of the Cell (© Garland Science 2008)

Quatro classes funcionais de
junções celulares nos tecidos
• A- junções ancorantes: célula-célula ou célula-matriz ao qual
a força de stress é transmitida ao citoesqueleto;
• B- junção oclusiva: sela os espaços entre células epitelias;
• C: junção mediada por canais
• D: junção de transferência de sinais
Figure 19-2 Molecular Biology of the Cell (© Garland Science 2008)

Junções em células epiteliais
Figure 19-3 Molecular Biology of the Cell (© Garland Science 2008)

Figure 19-4 Molecular Biology of the Cell (© Garland Science 2008)

Caderina medeia adesão célula-
Figure 19-5 Molecular Biology of the Cell (© Garland Science 2008)
célula
Expressão de E-caderina

Figure 19-7 Molecular Biology of the Cell (© Garland Science 2008)

Table 19-3 Molecular Biology of the Cell (© Garland Science 2008)

Caderina possui interações
Figure 19-8 Molecular Biology of the Cell (© Garland Science 2008)
homofílicas

Estrutura e função da caderina
Figure 19-9a Molecular Biology of the Cell (© Garland Science 2008)

Figure 19-9b Molecular Biology of the Cell (© Garland Science 2008)

Figure 19-9c Molecular Biology of the Cell (© Garland Science 2008)

Figure 19-13 Molecular Biology of the Cell (© Garland Science 2008)

Figure 19-14 Molecular Biology of the Cell (© Garland Science 2008)

Figure 19-15 Molecular Biology of the Cell (© Garland Science 2008)

Estrutura dos
desmossomos
Figure 19-17a Molecular Biology of the Cell (© Garland Science 2008)

Figure 19-17b Molecular Biology of the Cell (© Garland Science 2008)

Figure 19-17c, d Molecular Biology of the Cell (© Garland Science 2008)

Figure 19-18 Molecular Biology of the Cell (© Garland Science 2008)

Pemphigus foliaceus

Figure 19-19a Molecular Biology of the Cell (© Garland Science 2008)

Figure 19-20 Molecular Biology of the Cell (© Garland Science 2008)

Figure 19-22b Molecular Biology of the Cell (© Garland Science 2008)

Figure 19-22c Molecular Biology of the Cell (© Garland Science 2008)

Figure 19-23 Molecular Biology of the Cell (© Garland Science 2008)

Figure 19-24 Molecular Biology of the Cell (© Garland Science 2008)

Figure 19-25 Molecular Biology of the Cell (© Garland Science 2008)

Figure 19-26a Molecular Biology of the Cell (© Garland Science 2008)

Figure 19-26b Molecular Biology of the Cell (© Garland Science 2008)

Figure 19-27 Molecular Biology of the Cell (© Garland Science 2008)

Figure 19-30 Molecular Biology of the Cell (© Garland Science 2008)

Síndrome de Peutz-Jeghers
Polipo Peutz-Jeghers

Junções em gap ou conexinas
Figure 19-33 Molecular Biology of the Cell (© Garland Science 2008)

Figure 19-34a Molecular Biology of the Cell (© Garland Science 2008)

Figure 19-34b Molecular Biology of the Cell (© Garland Science 2008)

Figure 19-35 Molecular Biology of the Cell (© Garland Science 2008)

Neurônios de retina injetados com Lucifer Yellow
Figure 19-37 Molecular Biology of the Cell (© Garland Science 2008)
Pré tratado com dopamina

Figure 19-39 (part 2 of 3) Molecular Biology of the Cell (© Garland Science 2008)

Figure 19-39 (part 3 of 3) Molecular Biology of the Cell (© Garland Science 2008)

Lamina basal da córnea
Figure 19-40 Molecular Biology of the Cell (© Garland Science 2008)

Figure 19-41 Molecular Biology of the Cell (© Garland Science 2008)

Figure 19-42a Molecular Biology of the Cell (© Garland Science 2008)

Figure 19-42b Molecular Biology of the Cell (© Garland Science 2008)

Figure 19-43 Molecular Biology of the Cell (© Garland Science 2008)

Figure 19-45 Molecular Biology of the Cell (© Garland Science 2008)

Hemidesmossomos
Figure 19-46 Molecular Biology of the Cell (© Garland Science 2008)

Figure 19-47 Molecular Biology of the Cell (© Garland Science 2008)

Table 19-4 Molecular Biology of the Cell (© Garland Science 2008)

Figure 19-51 Molecular Biology of the Cell (© Garland Science 2008)

Figure 19-52a Molecular Biology of the Cell (© Garland Science 2008)
Adesão focal

Figure 19-52b,c Molecular Biology of the Cell (© Garland Science 2008)

Table 19-5 Molecular Biology of the Cell (© Garland Science 2008)

Figure 19-53 Molecular Biology of the Cell (© Garland Science 2008)

Figure 19-54 Molecular Biology of the Cell (© Garland Science 2008)

Figure 19-56 Molecular Biology of the Cell (© Garland Science 2008)

Figure 19-57 Molecular Biology of the Cell (© Garland Science 2008)

Figure 19-58 Molecular Biology of the Cell (© Garland Science 2008)

Figure 19-59 Molecular Biology of the Cell (© Garland Science 2008)

Figure 19-60a Molecular Biology of the Cell (© Garland Science 2008)

Figure 19-60b Molecular Biology of the Cell (© Garland Science 2008)

Figure 19-61 Molecular Biology of the Cell (© Garland Science 2008)

Colágeno
Figure 19-62 Molecular Biology of the Cell (© Garland Science 2008)

Figure 19-63 Molecular Biology of the Cell (© Garland Science 2008)

Figure 19-64 Molecular Biology of the Cell (© Garland Science 2008)

Figure 19-65 Molecular Biology of the Cell (© Garland Science 2008)

Aorta
Figure 19-70a Molecular Biology of the Cell (© Garland Science 2008)

Fibras elásticas
na aorta
Figure 19-70b Molecular Biology of the Cell (© Garland Science 2008)

Figure 19-71 Molecular Biology of the Cell (© Garland Science 2008)

Figure 19-72 Molecular Biology of the Cell (© Garland Science 2008)
Fibronectina

Figure 19-73 Molecular Biology of the Cell (© Garland Science 2008)

FN: verde
Actina:vermelho
Figure 19-74 Molecular Biology of the Cell (© Garland Science 2008)