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fojk fldgioykjjk mßÉfPaoh - lekìfkdhsv m¾fhaIKlD;Su w.=¨fï w;r iS'tï' fcrdâ C.M. Gerard we;=`M lKavdhu úiska CB1 iy CB2 ridhkslw.=¨ tu wdldrhg u m¾fhaIKd.drfha § ksIamdokh lr jeä ÿr wOHhkh i`oydNdú; lf<a h' ñksia jDIK fldaI ;=< CB1 ridhksl w.=¨ ;sfnk nj fcrdâwe;=`M lKavdhu úiska fmkajd fok ,§'ñksia isref¾ CB1 w.=¨j, jHdma;sh ms<sn`o wOHkh lsÍug ;j;a lKavdhulgyels úh' fud<h" iqIqïkdj" m¾hka; iakdhq moaO;sh" wka;rdi¾. .%kaÓ moaO;sh"fu!;% ,sx.sl moaO;sh" wdydr ud¾. moaO;sh" fÄg .%kaÓ" ma,Sydj" jDIKfldaI iyyDoh jia;=j keue;s wjhjj, we;s iakdhq ffi, ;=< CB1 fodrgq nyq, nj fidhd.; yels úh'ñksidf.a reêr ffi, j¾.hla jk ,shqfldihsÜj, Leukocytes l%shdldß;ajhi`oyd CB1 ridhksl w.=¨ il%Sh ùu jeo.;a jk nj weï' njqfnda,d M. Bouaboulawe;=`M lKavdhu úiska fy<s lrk ,§'.¾NdIfha ridhksl w.=¨.eyekq i;=ka ms<sis`o .;a miq .¾NdI ì;a;sfha iakdhq ffi, ;=< CB1 w.=¨ixLHdj by< hk w;r fud<fhka Y%djh jk wdkkaouhsâ m%udKh o by<hhs' wdkkaouhsâ ridhkh ksid ore Wmf;a § ±fkk fõokdj wu;l lsÍugujg yelshdj ,efnk nj m¾fhaIlhskaf.a ks.ukh úh' isrer ;=< ksmojkwdkakouhsâj,g wu;l lrùfï yelshdj we;s neúka fmkS hkafka wu;llr,Su forgetfulness w;HjYH fohla nj h' wu;l lsÍfï yelshdj ksid wkjYHf;dr;=re ukiska bj;a lr uki msßisÿ lr .ekSug yels jk nj Tjqyq fmkajdÿkay'CB2 w.=¨fï w;r CB2 w.=¨ il%Sh lrjk lekìfkda,a fyj;a CBN ldxvfha ridhkksid wdrïN jk ffcj ridhksl l%shdjka ms<sn`o fidhd ne,Su msKsi m¾fhaIKisÿ úh' tys § fy<s jQfha m%;sYla;slrK moaO;shg wh;a jk ma,Sydj" .,uQ,.%ka:sh iy w.akHdYfha CB2 w.=¨ nyq, nj h' CBN ldxvfha ridhk úiskaCB2 w.=¨ ilS%h lrk ksid m%;sYla;slrK moaO;sh ld¾hlaIuj ls%hd lrk nj;afuu il%Sh lsÍfuka miqj isÿ jk ffcj ridhksl l%shd ksid wdidok" wkjYHffi, fn§ï iy nvjef,a ;=jd, we;s ùu je<flk nj;a fy<s úh' ;j o CBNridhk úiska CB2 w.=¨ ilS%h lsÍu ksid ufkdaNdjhkaf.a fjkia ùula we;sfkd jk w;r fud<h iy isrer w;r mKsúv yqjudrejg ndOd we;s fkd jknj o fidhd .ekqKs'fï w;r tka' B' lñkaiAls N.E. Kaminski we;=`M lKavdhu óhka fhdod f.kisÿ l< m¾fhaIKj,ska fy<s jQfha w.akHdYfha we;s tkfvdalekìfkdhsv .%yKhlrk CB2 w.=¨ ksid lekìfkdhsv ueÈy;a ù isÿ lrk m%;sYla;sh j¾Okh lsÍugisrerg yels jk nj h' tu yelshdj Cannabinoid-mediated Immune Modulationf,i ffjoH úoHd;aulj y`ÿkajd fohs'283

jika; fiak je,swx.ff;%f,dalHúchdfud<fha yeisÍulxid ÿu mdkh ksid ñksia fud<hg isÿjk n,mEu fidhd ne,Sug o m¾fhaIK isÿúh'ñksia isref¾ p,kh iy iunr;dj md,kh lrkafka wkquia;sIalh cerebellumúisks' th iEÈ we;s iakdhq ffi< ;=< we;s CB1 w.=¨" THC u.ska il%sh jQ úgp,kh kj;d úfõl .ekSug is;a fohs'jev ie<iqï lsÍu iy tajd l%shd;aul lsÍu iïnkaO ;SrK .kafka fud<fhauQ,ia: .Kavqlh basal ganglia u.sks' th ie§ we;s iakdhq ffi< ;=< ;sfnk CB1w.=¨" THC u.ska il%Sh jQ úg ;SrK .ekSu ld¾hlaIu fjhs'wdydr .ekSfï reÑh iy ,sx.sl l%shdjka md,kh lrkafka fud<fha we;syhsfmd;e,ui hypothalamus u.sks' th iEÈ we;s iakdhq ffi, ;=< ;sfnk CB1w.=¨" THC u.ska il%Sh jQ úg l=i.skak jeäfjk w;r ,sx.sl l%shdjkaj, § ;Sj%ixfõokhla we;s lrhs'ñksia isref¾ we;s we`.s,s iy hám;=< jeks m¾hka; m%foaY iy fud<h w;rmKsúv yqjudre lrkafka iqIqïkdj iy m¾hka; iakdhq moaO;sh u.sks' fuuikaksfõok moaO;sh iE§ we;s iakdhq ffi, ;=< ;sfnk CB1 w.=¨" THC u.skail%Sh jQ úg fõokdj keue;s ixfõokh fkd ±kS hhs'is;sú,s" ye`.Sï iy p,kh md,kh lrkafka uia;sIal w¾Of.da,j, ndyslhcerebral cortex u.sks' fuu fldgi iE§ we;s iakdhq ffi, ;=< ;sfnk CB1w.=,q" THC u.ska il%Sh jQ úg is;sú,s we;s ùu ld¾hlaIu fjhs'Wkkaÿj" wdidj iy wd;au ;Dma;sh we;s jkafka fud<fha we;s kshqla,shiawelshqïnkaia nucleus accumbens keue;s m%foaYfhys l%shdldß;ajh ksid h' fuyswe;s CB1 w.=¨" THC u.ska il%Sh jQ úg Wkkaÿj iy wdYdj jeä jk w;r Wmßuwd;au ;Dma;sh ,nd .; yels fjhs'ìh iy l,n,h jeks ye`.Sï md,kh lrkafka fud<fha we;s weñ.av,damygdala keue;s m%foaYh u.sks' fuu fldgi iE§ we;s iakdhq ffi, ;=< ;sfnkCB1 w.=¨" THC u.ska il%Sh jQ úg ie<ls,su;a nj jeä jk w;r l,n,hlskaf;dr j mdvqfõ jev lsÍug yels fjhs'u;lh iy f;dr;=re l<ukdlrKhg Woõ fokafka fud<fha we;sysfmdaleïmih hippocampus u.sks' fuu fldgi iE§ we;s iakdhq ffi, ;=<;sfnk CB1 w.=¨" THC u.ska il%Sh jQ úg OdrK Yla;sh jeä jk w;r f;dr;=rel<ukdlrKh myiq lr fohs'Ydluh-i;a;ajuh iy lD;s%u lekìfkdhsvfï jk úg lekìfkdhsv j¾. ;=kla ms<sn`o m¾fhaIK isÿ lr ;snqKs' tneúkaksmojk uQ,dY%h wkqj lekìfkdhsv j¾. lsÍug ;SrKh úh' tajd my; wdldrhgw¾: oelaù h'lxid Ydlfhka ksmojk iajdNdúl lekìfkdhsv mhsfgdalekìfkdhsvphytocannabinoid kï úh' mÍlaIKd.drj, § ksmojk tajd lD;%sulekìfkdhsv synthetic cannabinoid kï úh' cSúkaf.a isrere ;=< ksmojk úg284

fojk fldgi

oykjjk mßÉfPaoh - lekìfkdhsv m¾fhaIK

lD;Su w.=¨

fï w;r iS'tï' fcrdâ C.M. Gerard we;=`M lKavdhu úiska CB1 iy CB2 ridhksl

w.=¨ tu wdldrhg u m¾fhaIKd.drfha § ksIamdokh lr jeä ÿr wOHhkh i`oyd

Ndú; lf<a h' ñksia jDIK fldaI ;=< CB1 ridhksl w.=¨ ;sfnk nj fcrdâ

we;=`M lKavdhu úiska fmkajd fok ,§'

ñksia isref¾ CB1 w.=¨j, jHdma;sh ms<sn`o wOHkh lsÍug ;j;a lKavdhulg

yels úh' fud<h" iqIqïkdj" m¾hka; iakdhq moaO;sh" wka;rdi¾. .%kaÓ moaO;sh"

fu!;% ,sx.sl moaO;sh" wdydr ud¾. moaO;sh" fÄg .%kaÓ" ma,Sydj" jDIKfldaI iy

yDoh jia;=j keue;s wjhjj, we;s iakdhq ffi, ;=< CB1 fodrgq nyq, nj fidhd

.; yels úh'

ñksidf.a reêr ffi, j¾.hla jk ,shqfldihsÜj, Leukocytes l%shdldß;ajh

i`oyd CB1 ridhksl w.=¨ il%Sh ùu jeo.;a jk nj weï' njqfnda,d M. Bouaboula

we;=`M lKavdhu úiska fy<s lrk ,§'

.¾NdIfha ridhksl w.=¨

.eyekq i;=ka ms<sis`o .;a miq .¾NdI ì;a;sfha iakdhq ffi, ;=< CB1 w.=¨

ixLHdj by< hk w;r fud<fhka Y%djh jk wdkkaouhsâ m%udKh o by<

hhs' wdkkaouhsâ ridhkh ksid ore Wmf;a § ±fkk fõokdj wu;l lsÍug

ujg yelshdj ,efnk nj m¾fhaIlhskaf.a ks.ukh úh' isrer ;=< ksmojk

wdkakouhsâj,g wu;l lrùfï yelshdj we;s neúka fmkS hkafka wu;l

lr,Su forgetfulness w;HjYH fohla nj h' wu;l lsÍfï yelshdj ksid wkjYH

f;dr;=re ukiska bj;a lr uki msßisÿ lr .ekSug yels jk nj Tjqyq fmkajd

ÿkay'

CB2 w.=¨

fï w;r CB2 w.=¨ il%Sh lrjk lekìfkda,a fyj;a CBN ldxvfha ridhk

ksid wdrïN jk ffcj ridhksl l%shdjka ms<sn`o fidhd ne,Su msKsi m¾fhaIK

isÿ úh' tys § fy<s jQfha m%;sYla;slrK moaO;shg wh;a jk ma,Sydj" .,uQ,

.%ka:sh iy w.akHdYfha CB2 w.=¨ nyq, nj h' CBN ldxvfha ridhk úiska

CB2 w.=¨ ilS%h lrk ksid m%;sYla;slrK moaO;sh ld¾hlaIuj ls%hd lrk nj;a

fuu il%Sh lsÍfuka miqj isÿ jk ffcj ridhksl l%shd ksid wdidok" wkjYH

ffi, fn§ï iy nvjef,a ;=jd, we;s ùu je<flk nj;a fy<s úh' ;j o CBN

ridhk úiska CB2 w.=¨ ilS%h lsÍu ksid ufkdaNdjhkaf.a fjkia ùula we;s

fkd jk w;r fud<h iy isrer w;r mKsúv yqjudrejg ndOd we;s fkd jk

nj o fidhd .ekqKs'

fï w;r tka' B' lñkaiAls N.E. Kaminski we;=`M lKavdhu óhka fhdod f.k

isÿ l< m¾fhaIKj,ska fy<s jQfha w.akHdYfha we;s tkfvdalekìfkdhsv .%yKh

lrk CB2 w.=¨ ksid lekìfkdhsv ueÈy;a ù isÿ lrk m%;sYla;sh j¾Okh lsÍug

isrerg yels jk nj h' tu yelshdj Cannabinoid-mediated Immune Modulation

f,i ffjoH úoHd;aulj y`ÿkajd fohs'

283

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