2002 - Instituto de QuÃmica - USP
2002 - Instituto de QuÃmica - USP
2002 - Instituto de QuÃmica - USP
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Shaker Chuck FarahLABORATÓRIO DE ESTRUTURA,FUNÇÃO E INTERAÇÕES PROTÉICASLinhas <strong>de</strong> pesquisa:1) I<strong>de</strong>ntificação e Análise Funcional e Estruturaldas Interações Proteína-Proteína no fitopatógenoXanthomonas axonopodis pv citri.2) Determinação <strong>de</strong> estruturas moleculares <strong>de</strong>proteínas do fitopatógeno Xanthomonas axonopodispv citri por ressonância magnética nuclear ecristalografia.3) Investigações no mecanismo molecular <strong>de</strong>regulação <strong>de</strong> contração muscular.Summary1) I<strong>de</strong>ntification and functional and structuralanalysis of protein-protein interactions in the phytopathogenicbacteria Xanthomonas avonopodis pvcitri.2) Structural <strong>de</strong>termination of Xanthomonasaxonopodis pv citri proteins by nuclear magnetic resonanceand X-ray crystallography.3) Investigations into the molecular mechanismof the regulation of muscle contraction.Equipe:Pós-graduação: Adriana A. Paulucci, Aurea DeniseSousa, Eric Kors Vidsiunas, Leonor Galvão <strong>de</strong> Botton,Luis Marcelo Fernan<strong>de</strong>s Holthauzen, MarcosCastanheira AlegriaIniciação Científica: Aline <strong>de</strong> Jesus Barbosa, ÂngelaMika Katsuyama, Cristiane Rodrigues Ruzzo,Fernando Ta<strong>de</strong>u Bueno Martin, Maria Claudia PeredaRosa.Publicacações <strong>de</strong> ano <strong>2002</strong>:Galvão-Botton, L.M.P., Katsuyama, A.M., Almeida, F.C.L., Farah, C.S.and Valente, A.P. “High-throughput Screening of Xanthomonasaxonopodis pv citri structural proteomics targets using NMR” Submetido.Holthauzen, L.M.F. and Farah, C.S. “Ca2+-induced rolling of tropomyosinin muscle thin filaments: the ˜- and ˜-band concept revisited”Submetido.Valencia, F.F., Paulucci, A.A., Quaggio, R.B. Da Silva, A.C.R. Farah, C.S.and Reinach, F.C. “Parallel measurement of Ca2+-binding and fluorescenceemission upon Ca2+ titration of recombinant skeletal muscle troponinC: Measurement of sequential calcium binding to the regulatory sites”J. Biol. Chem. Aceito para publicação.Paulucci, A.A. Hicks, L., Machado, A., Miranda, M.T. M., Kay, C.M. andFarah, C.S. (<strong>2002</strong>) “Specific sequences <strong>de</strong>termine the stability andcooperativity of folding of the C-terminal half of tropomyosin” J. Biol.Chem. 277, 39574-39584.Sousa, A.D. and Farah, C.S. (<strong>2002</strong>) “Quantitative analysis of tropomyosinlinear polymerization equilibrium as a function of ionic strength” J.Biol. Chem. 277, 2081-2088.da Silva, A.C.R., Ferro, J.A., Reinach, F.C., Farah, C.S. et al. (<strong>2002</strong>) “Completegenome sequences of two Xanthomonas pathogens with similargenomes but different host specificities” Nature 417, 459-463.Reis, E.S., Baracho, G.V. Lima, A.S., Farah, C.S. and Isaac, L. (<strong>2002</strong>)“Homozygous hereditary C3 <strong>de</strong>ficiency due to a stop codon” Journal ofClinical Immunology 22, 321-330.Departamento <strong>de</strong> Química Bioquímica Fundamental95<strong>Instituto</strong> <strong>de</strong> Química - Pesquisa 2001 - <strong>2002</strong>