2002 - Instituto de QuÃmica - USP
2002 - Instituto de QuÃmica - USP
2002 - Instituto de QuÃmica - USP
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Alicia J. KowaltowskiREGULAÇÃO DA VITALIDADECELULAR POR MITOCÔNDRIASA função a<strong>de</strong>quada das mitocôndrias é essencialpara a maioria das células <strong>de</strong> mamíferos. Nosso grupotem como objetivo <strong>de</strong>finir os mecanismos pelos quaisa mitocôndria po<strong>de</strong> regular a vitalida<strong>de</strong> da célula,<strong>de</strong>terminando se haverá ou não morte celular. Paraesses estudos, utilizamos mo<strong>de</strong>los <strong>de</strong> morte celularenvolvendo órgãos inteiros, células em cultura eorganelas isoladas. Esperamos que nossos estudoscolaborem para o entendimento e prevenção <strong>de</strong>doenças como o infarto cardíaco, aci<strong>de</strong>nte vascularcerebral e <strong>de</strong>senvolvimento <strong>de</strong> tumores.SummaryMitochondrial function is essential for the viabilityof most mammalian cells. Our group studies themechanisms through which mitochondria can regulatecellular vitality, <strong>de</strong>termining if cell <strong>de</strong>ath will occur.These studies involve the use of whole organ,cell culture and isolated organelle mo<strong>de</strong>ls of cell<strong>de</strong>ath. We hope our results will contribute towardthe un<strong>de</strong>rstanding and prevention of many diseases,including myocardial infarction (heart attack), strokeand tumor <strong>de</strong>velopment.Publicações/Publications:Kowaltowski, A.J., Seetharaman, S., Paucek, P., Garlid K. (2001) Bioenergeticconsequences of mitochondrial ATP-sensitive K + channel Opening.Am. J. Physiol. 280: H649-657.Milani, G., Kowaltowski A.J., Saad, S.T.O., Metze, K., Vercesi, A.E. (2001)Walker tumor cells express larger amounts of the antiapoptotic proteinBcl-2 and presents higher resistance to toxic concentrations of Ca 2+ thanthe tumor cells K 562. Drug Development Research 52: 508-514.Kowaltowski, A.J., Vercesi, A.E. (2001) Reactive oxygen generation bymitochondria. Em: Mitochondria in Pathogenisis, J.J. Lemasters e A.-L.Nieminen, eds. Plenum Publishing Corporation, New York, E.U.A., pp.281-300Kowaltowski, A.J., Castilho, R.F., Vercesi, A.E. (2001) Mitochondrial permeabilitytransition and oxidative stress. FEBS Lett. 495: 12-15.Bajgar, R., Seetharaman, S., Kowaltowski, A.J., Garlid, K.D., Paucek, P.(2001) I<strong>de</strong>ntification and properties of a novel intracellular (mitochondrial)ATP-sensitive potassium channel in brain. J. Biol. Chem. 276: 33369-33374.dos Santos, P., Kowaltowski, A.J., Laclau, M.N., Seetharaman, S., Paucek,P., Boudina, S., Thambo, J.-B., Tariosse, L., Bonoron-Adèle, S., Garlid.K.D. (<strong>2002</strong>) Mechanisms by which opening the mitochondrial ATP-sensitivepotassium channel protects the ischemic heart. Am. J. Physiol. 283:H296-H301.Netto, L.E.S, Kowaltowski, A.J., Castilho, R.F., Vercesi, A.E. (<strong>2002</strong>) Thiolenzymes protecting mitochondria against oxidative damage. Meth.Enzymol. 348: 260-270.Belisle, E., Kowaltowski, A.J. (<strong>2002</strong>) Mitochondrial ATP-Sensitive K + channelsincrease ischemic ATP levels and prevent reperfusion injury. J.Bioenerg. Biomembr. 34: 285-298.Kowaltowski, A.J., Cosso, R.G., Campos, C.B., Fiskum, G. (<strong>2002</strong>) Effectof Bcl-2 overexpression on mitochondrial structure and function. J. Biol.Chem. 277: 42802-42807.Departamento <strong>de</strong> Química Bioquímica Fundamental9<strong>Instituto</strong> <strong>de</strong> Química - Pesquisa 2001 - <strong>2002</strong>