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cancer genes modules. Among them, FGFR1, DBN1, NUPR1, COL3A1, AOC3, IFITM1,CALCRL, NOVA2, MVP, MFAP5, DIP2C had positive correlation and CENPF, RHOH andBICD1 had negative correlation. Functional analysis of 75 genes modulators revealedthat they act mainly on cell cycle and cell growth and proliferation, confirming thefindings of independent CGH array and expression microarrays data. IGFBP5 and FGFR1genes were associated with proliferation and cell growth process, while COL3A1 wasassociated with cellular organization. These genes were located on the networksperiphery, connected to transcription factors, indicating that may act indirectly in thetranscription. In addition, COL3A1, IGFBP5 and FGFR1 genes have been associated withthe canonical pathway of proliferation of hepatic fibrosis and may be potentialtherapeutic targets. The findings of this study allowed to describe new CNVs regions,and also confirmed the involvement of others CNVs already described in LU. Genesmapped at CNVs regions were associated with transcriptional mechanisms and cellcycle. The global gene expression analysis revealed decreased activity of genes thatcontrol the processes of chromosomal recombination and DNA damage repair andincreased activity of genes associated with stimulation of proliferation andaccumulation of extracellular matrix. This new strategy of integrative genomic andtranscriptomic data reveals new potential molecular markers that could be used ontreatment of Uterine Leiomyoma, a common and poorly understood disease.iv