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inhibitor recently approved to renal cell carcinoma (RCC) treatment [47]. Pazopanib acts inRCC through its antiangiogenic properties via inhibition of the intracellular tyrosine kinases.Thus, FGFR1 amplification translated by up-regulation is a target of studies with drugs thatinhibit cellular growth in ULs menorrhagia-associated.The ERK (extracellular-regulated kinase)/MAPK (mitogen activated protein kinase)signaling is a key pathway that transduces cellular information on meiosis/mitosis, growth,differentiation and carcinogenesis. The HSPB7 encodes one heat shock 27kDa protein family,member 7 that has been associated with cardiomyopathy and belongs to ERK/MAPKsignaling [48]. To the best of our knowledge, this is the first report showing the involvementof HSPB7 in ULs.Vitamin D3-bound VDR-RXR, along with other co-activator proteins, mediates thetranscriptional regulation of a number of genes, including IGFBP5. This gene encodesinsulin-like growth factor binding protein 5 that stimulates gene targets transcription leadingto cell proliferation. Up-regulation of IGFBP5 has been associated with cervicalintraepithelial neoplasia and breast cancer [49, 50]. Therefore, increased activity of IGFBP5could be associated with estrogen-dependent tumors, as well as ULs.A principal pathway that signals through mTOR is the PI3K/AKT that is involved incell survival and proliferation. Crabtree et al. [39] reported the mammalian target ofrapamycin (mTOR) pathway as one of the most highly up-regulated pathways in both humanand rat ULs. The RHOH, associated with mTOR signaling, encodes a small G-like protein.Down-regulation of RHOH was associated with acute myeloid leukemia [51]). The presentfindings suggest that RHOH genomic losses and transcript down-regulation could beassociated with deregulation of cell cycle and mTOR signaling pathway in ULs.FAK signaling regulates a number of key cellular processes including growth factorinducedmitogenic signals, cell survival, cell proliferation and migration, cell locomotion and13