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The modulators were mainly associated with cancer involving cell cycle (P < 10 -4 ) andcellular growth and proliferation functions (P < 10 -3 ). Damage of cell cycle has beendescribed in the pathogenesis of several tumors [35, 36], including ULs [37, 38, 39]. Inaddition, cellular proliferation stimulated by growth factors and/or steroid hormones is one ofthe mechanisms accountable for volume increase observed in ULs tumors [5].Menorrhagia, characterized by excessive uterine bleeding, is one of the mostfrequently symptoms associated with ULs and may have implications for fertility andcontraception. The canonical pathway intrinsic mechanism for prothrombin activation beginswith trauma to the blood vessel or exposure of blood to collagen in a traumatized vessel wall.Prothrombin overactivation could be associated with excessive bleeding observed in affectedpatients [40]. In the present study, the gene associated with this pathway was COL3A1, whichshowed positive association. The up-regulation of this gene has been previously associatedwith increase of collagen deposition in ULs [41]. The in silico functional analysis revealedthat COL3A1 molecule was associated with response to collagenase Clostridium histolyticum,an treatment recently approved for progressive Dupuytren contractures disease (DD) [42]. DDis a fibroproliferative disorder of unknown etiology that often results in shortening andthickening of the palmar fascia, leading to permanent and irreversible flexion contracture ofthe digits [43]. Therefore, COL3A1 is as candidate gene for further studies aiming to evaluateits correlation with menorrhagia and fibroid formation in UL patients.Fibroblast growth factor receptor (FGFR), showing positive association in the presentstudy, belongs to the family of receptor tyrosine kinases (RTKs). Activated RTKs play animportant role in the enhanced proliferation described in ULs [for review 44]. In addition, upregulationof FGF1 was associated with menorrhagia in patients with ULs [45]. FGFR1 hasbeen reported as a potential therapeutic target in breast cancers [46]. The in silico functionalanalysis showed an association with FGF1 molecule and pazopanib, a tyrosine kinase12