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Cirilo, PDRRESULTADOS131Tabela 12. miRNAs mapeados em regiões de ganhos e perdas genômicas e o padrão de expressão de seus genes preditos.miRNA Região PosiçãoCGH array (n°casos)GeneMicroarray*hsa-mir-26b 2q35 218,975,612-218,975,689 Ganho (6) FA2H, OVOL2, E2F7, DEPDC1, NUP210, DEPDC1, DEPDC1B, SLC16A6, ABCD3,CDC6, NFE2L3, ZIC5, CTNND2, AP1S3, PMAIP1, FANCA, NUAK2, MAP2, DSCR6,MREG, SFXN1, FLVCR1, C11orf41, RAB3IP, GNPNAT1, FAM49B, BID, RAB3IP,RFC3, TFAM, C9orf40, AGPAT5, GMDS, GALNT10, DNMT3B, PTER, PCNA, -CELSR1, BID, ACSL3, C20orf24, STRBP, C20orf24, ROD1, ETNK1, LARP4,YWHAE, COX5A, NUP50, ALDH5A1, SLC7A6, BLOC1S2, YWHAE, SERBP1, NIP7,BCCIP, ERLIN1, RFK, ZNF655, GSR, CPSF2, RNF138, YWHAE, STRBPPerda (0) SMAD1, CTDSP2, LINGO1, USP25, PPP3CB, MRAS, ULK2, ZNF516, RAB31,DLG4, ZNF516, LRRC2, CDH11, PECAM1, GREB1, DNAJB5, DMD, KCNE4, DMD,CD200, CACNB2, PRELP, ADAMTS19, HSD17B6, CILP, SOX17, PGR, MUM1L1,+ASPNhsa-mir-1269 4q13.2 66,825,136-66,825,241 Ganho (0) JPH3, TTF2, TSR1, C16orf74, TSR1 -Perda (6) PLB1 +hsa-mir-1236 6p21.32 32,032,594-32,032,696 Ganho (4) CDKN2A, C15orf48, GALNT6, RHOBTB3, GFI1, DIO1, PVR, DPF3, SLA, CLPB,-WDR3, VAPBPerda (1) EPN2, MYCT1, SNED1, PPP1R1A, IGFBP5, ATP8B4 +hsa-mir-25 7q22.1 99,529,118-99,529,202 Ganho (9) DDX3Y, SLC7A11, PRDM13, PAX3, SOX11, JAKMIP1, GPR158, CXCL5, CLGN,PRDM15, MAGEC2, TRIP13, MCOLN2, MTHFD2, AURKA, HOXC8, ADM, CSMD3,Perda (3)GCLM, PTPN22, GCLM, ME1, TFAP2A, ZDHHC2, PLEKHB2, INSIG1, DOCK5,RGS17, TCFL5, PFKFB4, NF2, ASPH, TMED5, ASB7, GPR180, NLK, CHKA,ARFGEF2, ASB7, QSER1, NCBP1, NPC1, CDCA7L, IDH1, C20orf111, C18orf25,CCT6ALHFPL2, WDR81, ARHGEF17, PPP1R12C, FOXN3, VCL, PDCD6IP, ZFYVE21,KIAA1109, ARID5B, GPR124, PLEKHG3, RBPMS2, CACNA1H, NFIA, ACTC1,PCDH7, MITF, NFIX, CDKN1C, SPSB1, GATA6, FAM110B, ANGPTL2, ITPR1,RAB23, REV3L, HOXD10, C18orf1, FZD10, STARD13, JPH2, MSRB3, ADAMTS9,HAND2, ANGPTL2, COL1A2, GPR124, CACNA1C, NEFM, ACTC1, CACNA1C,PPAP2B, ATP2B4, LMO2, SCRG1, SLC24A3,hsa-mir-106b 7q22.1 99,529,551-99,529,633 Ganho (9) GDA, PLS1, RRM2, ESCO2, RRM2, ATAD2, ATAD2, ATAD2, LAMP3, RNF128,RAD51AP1, RAB11FIP4, C1orf135, GRHL2, RACGAP1, E2F2, FAM40B, MASTL,POLQ, MYO5B, RUNX3, HN1, KIF23, EYA1, CIT, CDCA7, HMGCS1, DPYSL5,CENPO, CKAP2, CKAP2, PRR15, RAB11FIP4, EPB41L5, SC4MOL, OLIG1, NIPA1,KPNA2, FNDC3B, PTPN3, E2F5, CKAP2, EIF2S1, SERPINB8, HAS2, SOLH,SH2D5, UBE3C, CENPO, SS18L1, E2F1, PANK3, DCBLD2, ARSJ, KIAA1598,RBL1, HSPA8, PREX1, PHF19, LIF, STK4, MASTL, HN1, LSM14B, CHAF1A,-+-