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ricardo aires - novembro 2008 - correo tese - Repositorio.ufc.br - UFC

ricardo aires - novembro 2008 - correo tese - Repositorio.ufc.br - UFC

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Secção através das junções celulares Claudinas basais, vista do topo<<strong>br</strong> />

Funções<<strong>br</strong> />

Celulares<<strong>br</strong> />

Lâmina Basal<<strong>br</strong> />

Células<<strong>br</strong> />

Epiteliais<<strong>br</strong> />

Claudinas<<strong>br</strong> />

Basais<<strong>br</strong> />

Via<<strong>br</strong> />

Paracelular<<strong>br</strong> />

Poro<<strong>br</strong> />

Aguoso<<strong>br</strong> />

Miosina<<strong>br</strong> />

Actina<<strong>br</strong> />

Citosol<<strong>br</strong> />

Epitelial<<strong>br</strong> />

Mem<strong>br</strong>ana<<strong>br</strong> />

Plasmática<<strong>br</strong> />

Espaço<<strong>br</strong> />

Paracelular<<strong>br</strong> />

Mem<strong>br</strong>ana<<strong>br</strong> />

Plasmática<<strong>br</strong> />

Citosol<<strong>br</strong> />

Epitelial<<strong>br</strong> />

Figura 8. Modelo especulativo dos poros nas junções celulares. As claudinas formam fileiras contínuas e<<strong>br</strong> />

adesões homotípicas e os resíduos extracelulares têm influência eletrostática no movimento paracelular de íons.<<strong>br</strong> />

Isto sugere que as claudinas formam poros seletivos na via paracelular. Os filamentos intracelulares conectam-se<<strong>br</strong> />

ao citoesqueleto de actina e miosina, explicando a regulação fisiológica da barreira pelo citoesqueleto.<<strong>br</strong> />

Fonte: VAN ITALIE; ANDERSON, 2004.<<strong>br</strong> />

Poro<<strong>br</strong> />

Poro<<strong>br</strong> />

Poro<<strong>br</strong> />

Poro<<strong>br</strong> />

129

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