Comparação Morfológica e Bioquímica entre Ratos Envelhecidos ...

Águila e col
Morfologia cardiaca e bioquímica após dieta hiperlipídica e com óleo de canola
do de novos estudos para compreender o que aconteceu
com o coração dos animais durante o experimento.
Freeman e col 70 , em estudo sobre a variação de peso
corporal e do coração, em ratos, observaram que existe redução
da massa miocárdica correlacionada com a perda de
peso corporal, o que não foi confirmado no nosso trabalho,
pois a correlação entre peso corporal e peso cardíaco não foi
estatisticamente significativa.
As curvas de sobrevivência dos animais foram diferentes
entre os grupos HxI e HxO. A mortalidade dos animais
foi maior no grupo H (9/15 óbitos ou 60% dos casos)
que nos outros grupos: um óbito apenas nos grupos I e O (1/
15 ou 6,7% dos casos, sendo que no grupo O a causa mortis
não foi natural e sim um acidente onde um animal escapou
da gaiola e ingeriu veneno destinado a ratos parasitas). A
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160
Referências
Arq Bras Cardiol
volume 68, (nº 3), 1997
alta mortalidade dos animais do grupo H, intensificada após
os animais completarem um ano de experimentação, provavelmente
é secundária ao uso de dieta hiperlipídica, com
alto teor de colesterol.
Em conclusão, observamos que, em ratos envelhecidos
sob dieta rica em óleo de canola (ácido graxo n-3), as alterações
morfológicas mesoscópicas cardíacas e metabólicas
foram menos intensas que em animais idosos e, principalmente,
animais de mesma idade sob dieta hiperlipídica.
Agradecimentos
Ao Dr Jairo Alves de Oliveira, farmacêuticobioquímico.
Trabalho parcialmente financiado pelo CNPq
52.16.22/93-0 e 52.23.73/95.0 e Faperj E-26/170.315/95.
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