efeitos da inibição do sistema renina-angiotensina-aldosterona e do ...
efeitos da inibição do sistema renina-angiotensina-aldosterona e do ...
efeitos da inibição do sistema renina-angiotensina-aldosterona e do ...
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Artigo 2<br />
Resumo apresenta<strong>do</strong> no Congresso Brasileiro de Cardiologia – Recife 2006-11-04, e na.<br />
Reunião de Pesquisa em Doença de Chagas e Leishmanioses – Uberaba 2006<br />
Clinical, Echocardiographic, Neurohormonal and Inflammatory<br />
Differences Between Chagas Cardiomyopathy Patients with and without<br />
Authors:<br />
Preserved Left Ventricular Systolic Function.<br />
FA. Botoni 1 , PA. Poole-Wilson 2 , DO. Okonko 2 , BMR. Oliveira 3 , MM. Teixeira 3 , AM. Reis 3 , AL.<br />
Ribeiro 3 , MOC. Rocha 3 - (1) Federal University of Minas Gerais , Belo Horizonte, Brazil (2)<br />
Clinical Cardiology, NHLI, Imperial College, Lon<strong>do</strong>n, United King<strong>do</strong>m (3) Federal University of<br />
Minas Gerais, Belo Horizonte, Brazil<br />
Background: the pathogenesis of chronic Chagas cardiomyopathy (CCC) is complex, but<br />
clinical, haemodynamic, neurohormonal and inflammatory responses seem similar to other<br />
cardiomyopathies. We compared these responses between CCC patients (pts) with and without<br />
systolic dysfunction, as left ventricular ejection fraction (LVEF) is a powerful prognostic<br />
determinant.<br />
Methods: a sub-analysis of a <strong>do</strong>uble-blind, placebo-controlled ran<strong>do</strong>mised trial in 42 pts with CCC<br />
was conducted. Patients were divided into those with LVEF ≤ 45% (group I) and those with LVEF<br />
> 45% (group II).<br />
Results: baseline mean (± SD) LVEF was 30.25 ± 8.12% in group I (n=20), and 55.0 ± 6.8% in<br />
group II (n=22). Framingham score (group I - 3.2 ±1.7; group II - 1.4 ± 1.1 – p=0.01), NYHA class<br />
(group I - NYHA I = 6/20, II = 10/20, III 4/20; group II - NYHA I= 16/22, II = 4/22, III = 2/22;<br />
p=0.015) differed between groups. Three SF36 physical parameters were significantly (p